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Evaluation of targeted oxidative stress induced by oxygen-ozone < em > in vitro < /em > after ischemic induction
Redox Rep. 2022 Dec;27(1):259-269. doi: 10.1080/13510002.2022.2143104.ABSTRACTEncephalic vascular accident, or stroke, is the most common pathology of the central nervous system in humans, the second leading cause of death and physical and cognitive disabilities, in developing countries. It presents as an ischemic (more common) or hemorrhagic form. Ozone therapy has been shown to be effective in neuromodulation, neuroprotection, and nerve regeneration. The present study aimed to evaluate the effect of targeted mild ozone after inducing cerebral ischemia in vitro. Neuroblastoma lineage cells (SH-SY5Y) and canine amniotic me...
Source: Redox Report : communications in free radical research - November 10, 2022 Category: Biochemistry Authors: Jessica Rodrigues Orlandin Sarah Ingrid Pinto Santos Luciana Cristina Machado Paulo Fantinato Neto Fabiana Fernandes Bressan Naira Caroline Godoy Pieri Kaiana Recchia Meline de Paula Coutinho Priscilla Avelino Ferreira Pinto Annalisa Santucci Valter Trava Source Type: research

Levetiracetam, an antiepileptic drug has neuroprotective effects on intracranial hemorrhage injury
Publication date: Available online 11 February 2020Source: NeuroscienceAuthor(s): Takahiko Imai, Tomoki Sugiyama, Sena Iwata, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki HaraAbstractIntracranial hemorrhage (ICH) is a devastating disease that induces hematoma formation with poor neuronal outcome. Levetiracetam (LEV) has been approval for epilepsy seizures. In a previous study, LEV exerted protective effects on cerebral ischemia models; however, the detail effects and the influence of LEV on ICH are still unknown. The aim of this study was to investigate whether oral administration of LEV (50 or 150 mg/kg) has protective...
Source: Neuroscience - February 13, 2020 Category: Neuroscience Source Type: research

Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R Abstract Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in specific...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states
Abstract Hemopexin provides neuroprotection in mouse models of stroke and intracerebral hemorrhage and protects neurons in vitro against heme or reactive oxygen species (ROS) toxicity via heme oxygenase‐1 (HO1) activity. To model human brain neurons experiencing hemorrhages and inflammation, we used human neuroblastoma cells, heme‐hemopexin complexes and physiologically‐relevant ROS, e.g. H2O2 and HOCl, to provide novel insights into the underlying mechanism whereby hemopexin safely maintains heme and iron homeostasis. Human amyloid precursor protein (hAPP), needed for iron export from neurons, is induced ~2‐fold a...
Source: Journal of Neurochemistry - January 25, 2013 Category: Neurology Authors: Peter Hahl, Taron Davis, Cecilia Washburn, Jack T. Rogers, Ann Smith Tags: Original Article Source Type: research