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Genetic deletion of calcium/calmodulin-dependent protein kinase kinase ß (CaMKK ß) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice
Conclusions: Inhibition of CaMKK signaling exacerbated stroke outcome and increased BBB impairment, transcriptional inactivation and inflammatory responses in females after stroke. Therefore, CaMKK signaling may be a potential target for stroke treatment in both males and females.
Source: BMC Neuroscience - October 21, 2014 Category: Neuroscience Authors: Lin LiuLouise McCulloughJun Li Source Type: research

Role of serum ‐ and glucocorticoid‐inducible kinases in stroke
Abstract Increased expression of serum‐ and glucocorticoid‐inducible kinase 1 (SGK1) can be induced by stress and growth factors in mammals, and plays an important role in cancer, diabetes, and hypertension. A recent work suggested that SGK1 activity restores damage in a stroke model. To further investigate the role of SGKs in ischemic brain injury, we examined how SGK inhibitors influence stroke outcome in vivo and neurotoxicity in vitro. Infarct volumes were compared in adult mice with middle cerebral artery occlusion, followed by 24 h reperfusion, in the absence or presence of SGK inhibitors. Neurotoxicity assay,...
Source: Journal of Neurochemistry - May 24, 2016 Category: Neuroscience Authors: Koichi Inoue, Tiandong Leng, Tao Yang, Zhao Zeng, Takatoshi Ueki, Zhi ‐Gang Xiong Tags: Original Article Source Type: research

The interaction between intestinal microenvironment and stroke
CONCLUSION: The structure and function of the intestinal environment can influence neurological function and cerebral ischemic outcome. Improving the intestinal microenvironment by targeting the gut microbiota may be a new direction in treating stroke.PMID:37309254 | DOI:10.1111/cns.14275
Source: CNS Neuroscience and Therapeutics - June 13, 2023 Category: Neuroscience Authors: Linna Zhao Jie Xiao Songlin Li Yuying Guo Rong Fu Shengyu Hua Yuzheng Du Shixin Xu Source Type: research

3,6′‐dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation
Abstract Tumor necrosis factor‐α (TNF) plays a prominent role in the brain damage and functional deficits that result from ischemic stroke. It was recently reported that the thalidomide analog 3,6′‐dithiothalidomide (3,6′‐DT) can selectively inhibit the synthesis of TNF in cultured cells. We therefore tested the therapeutic potential of 3,6′‐DT in a mouse model of focal ischemic stroke. Administration of 3,6′‐DT immediately prior to a stroke or within 3 hr after the stroke reduced infarct volume, neuronal death, and neurological deficits, whereas thalidomide was effective only when administered prior to ...
Source: Journal of Neuroscience Research - February 13, 2013 Category: Neuroscience Authors: Jeong Seon Yoon, Jong‐Hwan Lee, David Tweedie, Mohamed R. Mughal, Srinivasulu Chigurupati, Nigel H. Greig, Mark P. Mattson Tags: Research Article Source Type: research

Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice
This study demonstrates a noninvasive intranasal delivery of apelin-13 after stroke, suggesting that the reduced inflammatory activities, decreased cell death, and increased angiogenesis contribute to the therapeutic benefits of apelin-13.
Source: ASN Neuro - September 21, 2015 Category: Neuroscience Authors: Chen, D., Lee, J., Gu, X., Wei, L., Yu, S. P. Tags: Original Article Source Type: research

Activation of σ1 and σ2 receptors by afobazole increases glial cell survival and prevents glial cell activation and nitrosative stress after ischemic stroke
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 3, 2016 Category: Neuroscience Authors: C. Katnik, A. Garcia, A. A. Behensky, I.E. Yasny, A. M. Shuster, S. B. Seredenin, A. V. Petrov, J. Cuevas Tags: Original Article Source Type: research

Candesartan Reduces the Hemorrhage Associated with Delayed Tissue Plasminogen Activator Treatment in Rat Embolic Stroke.
Abstract We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (tPA) administration after embolic stroke, widening the therapeutic time window of tPA. Adult male Wistar rats were subjected to embolic middle cerebral artery occlusion (eMCAO) and treated with either candesartan (1 mg/kg) alone early at 3 h, delayed tPA (10 mg/kg) alone at 6 h, the combi...
Source: Neurochemical Research - November 6, 2013 Category: Neuroscience Authors: Ishrat T, Pillai B, Ergul A, Hafez S, Fagan SC Tags: Neurochem Res Source Type: research

Role of serum‐ and glucocorticoid‐inducible kinases in stroke
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - April 27, 2016 Category: Neuroscience Authors: Koichi Inoue, Tiandong Leng, Tao Yang, Zhao Zeng, Takatoshi Ueki, Zhi‐Gang Xiong Tags: Original Article Source Type: research

Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature.
We report herein incidence and clinical features of hyperacute onset PCD, a vertebrobasilar stroke mimic. We performed a retrospective analysis of all suspected PCD cases referred to the Udine University Hospital between 2009 and 2017. Our center provides the only neuroimmunology laboratory for three provinces of the Friuli-Venezia Giulia region, Italy (983,190 people as of January 1, 2017). Inclusion criteria were (1) abrupt onset of neurological symptoms; (2) initial consideration of a vascular etiology; (3) final diagnosis of "definite PCD." We also carried out a systematic review of the literature in order to identify ...
Source: Cerebellum - August 28, 2019 Category: Neuroscience Authors: Vogrig A, Bernardini A, Gigli GL, Corazza E, Marini A, Segatti S, Fabris M, Honnorat J, Valente M Tags: Cerebellum Source Type: research

In-hospital outcomes of thrombolysis for acute ischemic stroke in patients with primary brain tumors
Publication date: March 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 3 Author(s): Santosh B. Murthy , Yogesh Moradiya , Shreyansh Shah , Aditi Shastri , Eric M. Bershad , Jose I. Suarez Data on thrombolysis outcomes in patients with primary brain tumors are limited. Our aim was to study stroke outcomes following thrombolysis in these patients in a population-based study. Patients with acute ischemic stroke who received thrombolysis were identified from the 2002–2011 USA Nationwide Inpatient Sample. We compared demographics, comorbidities, and outcomes between primary brain tumor-associated strokes (BT...
Source: Journal of Clinical Neuroscience - February 16, 2015 Category: Neuroscience Source Type: research

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