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Total 153 results found since Jan 2013.

Teaching NeuroImages: Radiation-associated symptomatic carotid artery disease with ipsilateral radiodermatitis
A 68-year-old man with a history of squamous cell carcinoma of the tongue treated with external beam radiation therapy in 2007 presented in 2013 with acute onset expressive aphasia and right lower facial weakness. MRI confirmed an acute infarct in the left frontal cortex. CT angiography revealed occlusion vs critical stenosis of the left internal carotid artery, new from 2007. Examination of the patient's neck revealed ipsilateral radiodermatitis (figure). Therapeutic neck irradiation has been associated with accelerated atheromatous disease, carotid artery stenosis, and increased risk of stroke.1,2 Ipsilateral radiodermat...
Source: Neurology - February 2, 2015 Category: Neurology Authors: Ehrlich, M. E., Gulvezan, T., Southerland, A. M. Tags: All Imaging, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Talon noir: paring can eliminate the need for a biopsy
Introduction Talon noir (black heel or calcaneal petechiae) is a benign condition that appears as an asymmetric brown-black epidermal macule on the heel or elsewhere on the plantar foot. Punctate papillary dermal haemorrhages extend into the subcorneal space following shearing forces in an area of recurrent or sudden trauma.1 These lesions can mimic melanoma and haemorrhagic viral warts, especially in cases where there is no history of trauma. If the diagnosis of talon noir is considered, simple bedside tests can obviate the need for a biopsy to exclude malignant melanoma or unnecessary treatment for a presumed viral wart....
Source: Postgraduate Medical Journal - November 26, 2014 Category: Journals (General) Authors: Googe, A. B., Schulmeier, J. S., Jackson, A. R., Brodell, R. T. Tags: General practice / family medicine, Drugs: cardiovascular system, Pain (neurology), Stroke, Skin cancer, Screening (oncology), Radiology, Dermatology, Surgical diagnostic tests, General surgery, Epidemiology Images in medicine Source Type: research

Bm-12 * cerebral infarction secondary to pulmonary vein compression and left atrial appendage tumor infiltration as the presenting sign of metastatic squamous cell carcinoma of the base of the tongue
CONCLUSION: Cardiac metastases are rare and non-myxomatous tumor embolization to the brain even rarer especially in the setting of cerebral infarction due to pulmonary vein thrombus. Here we describe a case of multiple acute cerebral infarctions appearing from a proximal source refractory to anticoagulation. Thromboembolism from the pulmonary vein and tumor embolization from cardiac metastases are the likely mechanisms for his clinical presentation and radiographic findings. This case demonstrates the complexity of multiple stroke etiologies in one patient and the importance of cardiac imaging in stroke evaluation, particu...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Dredla, B., Siegel, J., Jaeckle, K. Tags: BRAIN METASTASES (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Concomitant low-dose doxorubicin treatment and exercise
Cardiotoxicity is a side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low-intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3 x 105) were injected subcutaneously into the scruff of 6- to 8-wk-old male C57BL/6 mice (n = 48). A 4 mg/kg cumulative dose of DOX was administered over 2 wk, and exercise (EX) consisted of treadmill walking (10 m/min, 45 min/day, 5 days/wk, 2 wk). Four experimental groups were tested: 1) sedentary (SED) + vehicl...
Source: AJP: Regulatory, Integrative and Comparative Physiology - September 15, 2014 Category: Physiology Authors: Sturgeon, K., Schadler, K., Muthukumaran, G., Ding, D., Bajulaiye, A., Thomas, N. J., Ferrari, V., Ryeom, S., Libonati, J. R. Tags: Cardiovascular and Renal Integration Source Type: research

Exercise may cut breast cancer risk, study finds
ConclusionThis large study has shown that increased exercise is associated with a reduced risk of breast cancer for postmenopausal women. Strengths of the study include the large number of women and that self-reports of breast cancer were verified by a pathology report in 94% of cases.However, as the authors point out, a limitation of this study is that it was conducted on a group of teachers who were mainly of a healthy weight. This means the results may not be applicable to women of a different weight with different occupations, including more or less sedentary jobs.The study also relied on self-reported exercise levels,...
Source: NHS News Feed - August 11, 2014 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news

Concomitant Low Dose Doxorubicin Treatment and Exercise.
Abstract Cardiotoxicity is a common side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3x10(5)) were injected subcutaneously into the scruff of 6-8 week old male C57BL/6 mice (n= 48). A 4 mg/kg cumulative dose of DOX (IP) was administered over 2 weeks (2 mg/kg, 1 day/week) and exercise (EX) consisted of treadmill walking (10 m/min, 45 min/d, 5 days/week, 2 weeks). Four experi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 9, 2014 Category: Physiology Authors: Sturgeon K, Schadler K, Muthukumaran G, Ding D, Bajulaiye A, Thomas NJ, Ferrari VA, Ryeom S, Libonati JR Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

A Case Series Of Non-Bacterial Thrombotic Endocarditis Associated With Gynecological Malignancies (P6.248)
Conclusions:NBTE is an important ischemic stroke mechanism. We have reported three cases where the underlying malignancy was gynecological (endometrial, ovarian, and cervical). In the first two cases, the malignancy was discovered during the investigations for the stroke mechanism, while the third had a known underlying malignancy. This series highlights the need to consider gynecological malignancies as an underlying cause of stroke in young women; and that the ischemic event can occur prior to the malignancy diagnosis.Disclosure: Dr. Schabas has nothing to disclose. Dr.Teal has received personal compensation for activiti...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Schabas, A., Teal, P., Yip, S., Mann, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Small study finds that 3 years after prostate cancer treatment, men may report high quality of life and functioning
Commentary on: Jakobsson L, Persson L, Lundqvist P. Daily life and life quality 3 years following prostate cancer treatment. BMC Nurs 2013;12:11. Implications for practice and research The male patients in this study reported high levels of quality of life, with high ratings for overall physical functioning and health. They appeared to adjust to the diminished sexual function. Nurses can use these outcomes and the results from other studies to inform patients. Nurses should understand that each individual will have a different prediagnosis level of and valuation of sexual activity/function. Further multicentred large studi...
Source: Evidence-Based Nursing - March 14, 2014 Category: Nursing Authors: Albaugh, J. Tags: Adult nursing, Stroke, Prostate cancer, Urological cancer, Sexual and gender disorders, Prostate, Health education Source Type: research

Little proof sunbathing cuts heart attack risk
Conclusion This laboratory study has found that UVA exposure caused a short-term drop in blood pressure and an increase in blood flow. The researchers believe that this is as a result of nitric oxide being released from the skin into the bloodstream. However, the researchers' assertion that this study "has significant public health implications" is open to question. Such a bold statement should probably only be made if further controlled studies are carried out to see whether UVA exposure can reduce the risk of death as a result of cardiovascular disease, and whether UVA exposure can reduce blood pressure in peo...
Source: NHS News Feed - January 21, 2014 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Cancer Source Type: news

Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)
Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
Source: Annals of the Rheumatic Diseases - December 4, 2013 Category: Rheumatology Authors: Dougados, M., Soubrier, M., Antunez, A., Balint, P., Balsa, A., Buch, M. H., Casado, G., Detert, J., El-zorkany, B., Emery, P., Hajjaj-Hassouni, N., Harigai, M., Luo, S.-F., Kurucz, R., Maciel, G., Mola, E. M., Montecucco, C. M., McInnes, I., Radner, H., Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoporosis, Rheumatoid arthritis, Epidemiology, Calcium and bone Clinical and epidemiological research Source Type: research

Preparation of well-defined ibuprofen prodrug micelles by RAFT polymerization.
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevated risk of stroke, however, can limit their use and exploration in new indications.　Here we report a facile method to prepare well-defined amphiphilic diblock copolymer NSAID prodrugs by direct reversible addition fragmentation transfer (RAFT) polymerization of the acrylamide derivative of ibuprofen (IBU), a widely used NSAID. The synthesis and self-as...
Source: Biomacromolecules - August 12, 2013 Category: Biochemistry Authors: Hasegawa U, van der Vlies AJ, Wandrey C, Hubbell JA Tags: Biomacromolecules Source Type: research

Evaluation of Reconstructive Techniques for Anterior and Middle Skull Base Defects Following Tumor Ablation
Conclusions: Vascularized flaps provide reliable and durable reconstructive options for anterior and middle skull base defects after resection of large complex malignant neoplasms of the craniofacial region. Free flaps, such as RFFFs, ALTs, and TDAPs, are well suited for these defects. They have a low risk of complications and low donor-site morbidity and offer good functional and esthetic outcomes.
Source: Journal of Oral and Maxillofacial Surgery - July 15, 2013 Category: ENT & OMF Authors: Jayini S. Thakker, Rui Fernandes Tags: Surgical Oncology and Reconstruction Source Type: research

UNMC Nanotechnology Protects Skin From Cancer And Early Wrinkles
Nanotechnology developed at the University of Nebraska Medical Center could strengthen things like sunscreen and anti-aging cosmetics into more potent barriers, protecting the skin from UV radiation that can cause wrinkles and skin cancer. A new startup company, ProTransit Nanotherapy, L.L.C., was founded on the innovation, and hopes to commercialize the nontoxic, biodegradable system within the next 18 months. If successful, the nanotechnology could serve as a platform that can deliver targeted treatments to a vast range of ailments, including stroke and heart disease...
Source: Health News from Medical News Today - July 10, 2013 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Time trends of incidence of age-associated diseases in the US elderly population: medicare-based analysis
Conclusion: time trends of the incidence of diseases common in the US elderly population were evaluated. The results show dramatic increase in incidence rates of melanoma, goiter, chronic renal and Alzheimer's disease in 1992–2005. Besides specifying widely recognised time trends on age-associated diseases, new information was obtained for trends of asthma, ulcer and goiter among the older adults in the USA.
Source: Age and Ageing - June 17, 2013 Category: Geriatrics Authors: Akushevich, I., Kravchenko, J., Ukraintseva, S., Arbeev, K., Yashin, A. I. Tags: Research Papers Source Type: research

Sun Exposure Could Benefit Health And Prolong Life
Exposing skin to sunlight may help to reduce blood pressure, cut the risk of heart attack and stroke - and even prolong life, a study suggests. Researchers have shown that when our skin is exposed to the sun's rays, a compound is released in our blood vessels that helps lower blood pressure. The findings suggest that exposure to sunlight improves health overall, because the benefits of reducing blood pressure far outweigh the risk of developing skin cancer. The study has been carried out by the University of Edinburgh...
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Hypertension Source Type: news