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Cancer: Myeloma

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Total 82 results found since Jan 2013.

Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated with drowsiness and peripheral neuropathy. Hence, there is intense interest to synthesize, identify and develop safer analogs.Researchers at the National Institute on Aging’s Drug Design and Development Section synthesized novel thalidomide analogs that demonstrate clinical potent...
Source: NIH OTT Licensing Opportunities - December 23, 2015 Category: Research Authors: admin Source Type: research

Induction therapy alters plasma fibrin clot properties in multiple myeloma patients: association with thromboembolic complications
Induction therapy in patients with multiple myeloma increases the risk of thromboembolism. We have recently shown that multiple myeloma patients tend to form denser fibrin clots displaying poor lysability. We investigated the effect of induction therapy on fibrin clot properties in multiple myeloma patients. Ex-vivo plasma fibrin clot permeability, turbidity, susceptibility to lysis, thrombin generation, factor VIII and fibrinolytic proteins were compared in 48 multiple myeloma patients prior to and following 3 months of induction therapy, mainly with cyclophosphamide-thalidomide-dexamethasone regimen. Patients on thrombop...
Source: Blood Coagulation and Fibrinolysis - August 5, 2015 Category: Hematology Tags: Original Articles Source Type: research

Central Nervous System Complications and Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation
Conclusions The occurrence of CNSCs after ALLO-HSCT was associated with reduced survival. Identifying patients at risk, monitoring, early detection and management of CNSCs post ALLO-HSCT is needed to improve outcomes. Teaser This retrospective study of 351 patients, who have undergone allogeneic hematopoietic stem cell transplantation between 2002 and 2011 at the University of Nebraska Medical Center, demonstrated 12% incidence of central nervous system complications. The most common complications included posterior reversible encephalopathy syndrome (40%), stroke or transient ischemic attack (24%), seizures (20%), and inf...
Source: Clinical Lymphoma Myeloma and Leukemia - June 30, 2015 Category: Cancer & Oncology Source Type: research

Pneumonia: When Antibiotics Are Not the Answer
We present the case of an 88-year-old bedridden man, with hypertension, multiple myeloma, coronary artery disease, ischemic stroke, seizures, dysphagia, and constipation under treatment with mineral oil. He was brought to the emergency department after 3 days of cough, dysphagia, and dyspnea, following a recent hospitalization, due to a health care–associated pneumonia. A chest computed tomography scan obtained showed bilateral multifocal opacities with consolidates described as Hounsfield units of −62, consistent with fat. A diagnosis of lipoid pneumonia was done, and mineral oil was discontinued. Given the patient’...
Source: Infectious Diseases in Clinical Practice - October 31, 2014 Category: Infectious Diseases Tags: Case Reports Source Type: research

Influence of Conventional Cardiovascular Risk Factors and Lifestyle Characteristics on Cardiovascular Disease After Hematopoietic Cell Transplantation Health Services and Outcomes
Conclusion Attention of clinicians to conventional cardiovascular risk factors and modifiable lifestyle characteristics offers hope of reducing serious cardiovascular morbidity after HCT.
Source: Journal of Clinical Oncology - January 17, 2014 Category: Cancer & Oncology Authors: Chow, Baker, Lee, Flowers, Cushing-Haugen, Inamoto, Khera, Leisenring, Syrjala, Martin Tags: Leukemia, Lymphoma, Myeloma, Outcomes Research Health Services and Outcomes Source Type: research

Pseudo-stroke manifestation of multiple myeloma: a report of two cases with literature review.
We describe two patients with pseudo-stroke manifestation of multiple myeloma. The first patient was a 60-year-old female with the initial presentation of multiple myeloma forming a large skull tumour compressing the brain with resultant symptoms of aphasia, limited logical contact and right upper extremity paresis. The second patient was a 69-year-old female who presented with a partial motor epileptic seizure involving both right limbs with persisting weakness of muscles and speech disturbances due to a skull tumour 4 years after the diagnosis of multiple myeloma. Pseudo-stroke manifestation of multiple myeloma is extrem...
Source: Folia Neuropathologica - May 26, 2013 Category: Pathology Authors: Czapiewski P, Szmuda T, Dzierżanowski J, Słoniewski P, Sworczak K, Gnacińska M, Dubaniewicz-Wybieralska M, Hellmann A, Biernat W Tags: Folia Neuropathol Source Type: research