• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Systematic analysis of brain and skull ischemic injury expression profiles reveals associations of the tumor immune microenvironment and cell death with ischemic stroke
ConclusionThis systematic analysis not only helps in the understanding of the changes in the gene expression profiles of both the brain and skull with ischemic injury but also reveals the association of the tumor immune microenvironment and cell death with ischemic stroke.
Source: Frontiers in Immunology - December 20, 2022 Category: Allergy & Immunology Source Type: research

Cancers, Vol. 14, Pages 118: Percutaneous Hepatic Perfusion (PHP) with Melphalan in Liver-Dominant Metastatic Uveal Melanoma: The German Experience
In conclusion, PHP is a safe and effective salvage treatment for liver-dominant metastatic uveal melanoma. Serious AEs—though rare—demand careful patient selection.
Source: Cancers - December 27, 2021 Category: Cancer & Oncology Authors: Cornelia L. A. Dewald Mia-Maria Warnke Roland Br üning Martin A. Schneider Peter Wohlmuth Jan B. Hinrichs Anna Saborowski Arndt Vogel Frank K. Wacker Tags: Article Source Type: research

Malignant melanoma - the most severe skin cancer and neurological pathology.
CONCLUSIONS: Neurological involvement in MM encompasses a myriad of variants and while the clinical setting varies from one patient to another, an underlining neoplasia should be evaluated in suspected patients. PMID: 32239096 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - April 5, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors Signal Transduction
We previously reported that the cell cycle–related cyclin-dependent kinase 4–retinoblastoma (RB) transcriptional corepressor pathway is essential for stroke-induced cell death both in vitro and in vivo. However, how this signaling pathway induces cell death is unclear. Previously, we found that the cyclin-dependent kinase 4 pathway activates the pro-apoptotic transcriptional co-regulator Cited2 in vitro after DNA damage. In the present study, we report that Cited2 protein expression is also dramatically increased following stroke/ischemic insult. Critically, utilizing conditional knockout mice, we show that Cited2 is r...
Source: Journal of Biological Chemistry - May 23, 2019 Category: Chemistry Authors: Tianwen Huang, Yasmilde Rodriguez Gonzalez, Dianbo Qu, En Huang, Farzaneh Safarpour, Eugene Wang, Alvin Joselin, Doo Soon Im, Steve M. Callaghan, Wassamon Boonying, Lisa Julian, Sally L. Dunwoodie, Ruth S. Slack, David S. Park Tags: Molecular Bases of Disease Source Type: research

The technique of superselective ophthalmic artery chemotherapy for retinoblastoma: The Garrahan Hospital experience.
Conclusion SOAC is a safe technique with a very low complication rate. PMID: 29119878 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - November 10, 2017 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.
This study was aimed to investigate whether knockdown of Id2 in neuronal cells could protect them from hypoxic and ischemic injury both in vitro and in vivo. Flow cytometric analysis was employed to assess neuronal apoptosis in CoCl2-treated neuroblastoma B35 cells engineered to overexpress or knockdown Id2 expression. In vivo knockdown of Id2 was performed in Sprague-Dawley rats by a single intracerebroventricular injection of Cy3-labeled and cholesterol-modified Id2-siRNA. We found that knockdown of Id2 attenuated H/I-induced neuronal apoptosis in vitro while overexpression of Id2 produced an opposite effect. In a rat mo...
Source: Behavioural Brain Research - July 14, 2015 Category: Neurology Authors: Guo L, Yang X, Lin X, Lin Y, Shen L, Nie Q, Ren L, Guo Q, Que S, Qiu Y Tags: Behav Brain Res Source Type: research