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Total 88 results found since Jan 2013.

Long-term smoking 'may cause' brain shrinkage
Conclusion This study has shown an association between smoking and a thinner cortex, though it cannot prove that smoking caused the cortex to thin. The study was cross sectional, so cannot say which came first – the smoking or the cortex differences. Also, confounding factors other than smoking may be contributing. Strengths of the study include: Having access to measurements of cognitive ability when the participants were 11 years old, before most of them would have started smoking, as a potential indicator of cortex thickness. The radiologists were blinded to which MRIs came from each group, reducing the risk of ...
Source: NHS News Feed - February 12, 2015 Category: Consumer Health News Tags: Lifestyle/exercise Neurology Source Type: news

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program
The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain‐only donations and currently has banked more than 1600 brains. More than 430 whole‐body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also dire...
Source: Neuropathology - January 26, 2015 Category: Neurology Authors: Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Geidy Serrano, Holly A. Shill, Douglas G. Walker, LihFen Lue, Alex E. Roher, Brittany N. Dugger, Chera Maarouf, Alex C. Birdsill, Anthony Intorcia, Megan Saxon‐Labelle, Joel Pullen, Alexander Scroggins, J Tags: SYMPOSIUM: BRAIN BANK Source Type: research

Inactivity 'twice as deadly' as obesity
Conclusion This study’s strengths included its large size and long follow-up period. Researchers also took into account a large number of factors (called confounders) that might have influenced the risk of death, such as diet, smoking history and alcohol intake, although it is still possible that both measured and unmeasured confounders influenced mortality rates. The study had one important limitation. It only measured people’s BMI (calculated by combining their weight and height) and their physical activity once, at the start of the study. It is quite possible that people’s BMI changed over time, and that this wou...
Source: NHS News Feed - January 15, 2015 Category: Consumer Health News Source Type: news

Scientists wield plant viruses against deadly human disease
(Case Western Reserve University) Case Western Reserve University researchers have won grants to customize a plant virus into a vaccine for an aggressive form of breast cancer, and to turn another plant virus into a transporter that delivers clot-busting drugs to a blood clot before it causes a heart attack or stroke.
Source: EurekAlert! - Cancer - October 1, 2014 Category: Cancer & Oncology Source Type: news

Abstract 4058: Acid-sensing ion channel 1a (ASIC1a) contributes to cell proliferation and migration caused by acidic environment in human glioma cells
Conclusions: Extracellular acid reduces proliferation and migration in glioma cells. Extracellular acid induces death of glioma cells via ASIC1a mechanisms. These results indicate the presence of ASIC1a in glioma cells and may play significant role in glioma progression. This work was supported by the National Institutes of Health grant numbers NIH R01NS047506, R01NS066027, UL1 RR025008, U54 RR026137, AHA 0840132N, and ALZ IIRG-10-173350. Citation Format: Mingli Liu, Alyssa (Aihui) Guo, Christopher Ghiathi, Zhigang Xiong. Acid-sensing ion channel 1a (ASIC1a) contributes to cell proliferation and migration caused by acidic ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Liu, M., Guo, A., Ghiathi, C., Xiong, Z. Tags: Tumor Biology Source Type: research

Response to: 'Overweight/obesity and vitamin D deficiency contribute to the global burden of low back pain' by Professor Grant
We would like to thank William B Grant for his letter1 on our paper ‘The global burden of low back pain: estimates from the Global Burden of Disease 2010 study’.2 We fully agree with Professor Grant on the enormous potential that population-wide interventions have for reducing the global burden of low back pain. While more research is needed, the evidence base for several population-based interventions is already well established. For example, globally, and in low-income and middle-income countries in particular, population-based strategies that increase physical activity and reduce obesity are likely to have a...
Source: Annals of the Rheumatic Diseases - July 3, 2014 Category: Rheumatology Authors: Hoy, D., March, L., Brooks, P., Blyth, F., Woolf, A., Smith, E., Buchbinder, R. Tags: Electronic pages Source Type: research

Statins side effects are minimal, study argues
ConclusionThis meta-analysis pooled results from 29 studies and has shown a very small increased risk of newly diagnosed diabetes mellitus. This is the same as the decreased risk of any cause of death in people taking statins, compared to placebo, to prevent a heart attack or stroke.The researchers point out some limitations to the meta-analysis: Each study did not report on all of the side effects, meaning that for each category of side effect, the number of participants differed. The side effect categories were only included if at least 500 people had reported suffering from it. This means there may be numerous other si...
Source: NHS News Feed - March 13, 2014 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Tomato therapy: Engineered veggies target intestinal lipids, improve cholesterol
UCLA researchers report that tiny amounts of a specific type of lipid in the small intestine may play a greater role than previously thought in generating the high cholesterol levels and inflammation that lead to clogged arteries.   The team also found they could reduce the negative effects of these lipids in mice by feeding the animals a new genetically engineered tomato being developed at UCLA that is designed to mimic HDL ("good") cholesterol.   The study, published in the December issue of the Journal of Lipid Research with an accompanying editorial, focused on a group of lipids found in the sma...
Source: UCLA Newsroom: Health Sciences - November 13, 2013 Category: Universities & Medical Training Source Type: news

Children of obese mums may die younger
Conclusion This valuable research has examined a large cohort of 28,540 Scottish women who had their BMI measured during pregnancy and gave birth to a single baby between 1950 and 1976. Its strengths include the use of a reliable maternity database linking more than 80% of the offspring to national registers. This allowed the researchers to identify hospital discharges and mortality records for the children. The study suggests a link between mothers who are overweight or obese during pregnancy and an increased risk of their children's death overall – specifically prior to age 55 – as well as an increased risk of th...
Source: NHS News Feed - August 14, 2013 Category: Consumer Health News Tags: Obesity Pregnancy/child Source Type: news

157 E-Books New to JEFFLINE
Scott Library added these 157 e-books to the growing collection in May and June: Accurate Results in the Clinical Laboratory Adult Emergency Medicine Adult-Gerontology and Family Nurse Practitioner Certification Examination (4th ed.) Advanced Assessment: Interpreting Findings and Formulating Differential Diagnoses (2nd ed.) Advancing Your Career: Concepts of Professional Nursing (5th ed.) Arrhythmia Essentials Atlas of Advanced Operative Surgery Atlas of Clinical Neurology (3rd ed.) Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches Atlas of Human Infectious Diseases Atlas of No...
Source: What's New on JEFFLINE - June 25, 2013 Category: Databases & Libraries Authors: Gary Kaplan Tags: All News Clinicians Researchers Students Teaching Faculty Source Type: news

Using 1 grant to tackle 2 diseases
(University of New Mexico Cancer Center) Specialized cells, called "hematopoietic stem cells," produce the new blood cells. Scientists thought hematopoietic stem cells stayed in the bone marrow but recent research has revealed that they travel to the problem site: to the heart if a heart attack is in progress, or to the brain in the case of a stroke. Jennifer Gillette, Ph.D., will study why these cells leave the bone marrow and what they do when they reach their target.
Source: EurekAlert! - Medicine and Health - May 28, 2013 Category: Global & Universal Source Type: news

Boosting 'cellular garbage disposal' can delay the aging process, UCLA biologists report
UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.   The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells.   "Aging is a major risk factor for the development and progression of many neurodegenerative diseases," said David Walke...
Source: UCLA Newsroom: Health Sciences - May 6, 2013 Category: Universities & Medical Training Source Type: news

Even 'light' smoking may raise women's arthritis risk
Conclusion This research indicates that a relatively low level of smoking (one to seven cigarettes per day) is associated with an increased risk of developing rheumatoid arthritis compared with women who had never smoked. This adds further knowledge to previous research that has suggested that cigarette smoking is directly linked to a higher risk of developing rheumatoid arthritis. While this study is relatively robust and its results believable, it does have limitations that should be considered. It was not clear how many women dropped out of the study. If this was a large proportion of the women who started, it could si...
Source: NHS News Feed - April 23, 2013 Category: Consumer Health News Tags: Cancer Heart/lungs Lifestyle/exercise Source Type: news