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Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

No, Omega 3-Enriched Beef Is Not Necessarily Heart Healthy
Feeding cattle flaxseed or marine algae can raise the omega-3 fatty acid levels in ground beef from 30 milligrams per serving to 200 milligrams per serving, as Kansas State University researchers have found. But do higher levels of omega-3s make red meat significantly healthier?   Not according to Kim Larson, a registered dietitian nutritionist and spokesperson for the Academy of Nutrition and Dietetics. The attempt to make beef look like an important source of omega-3s is essentially a marketing ploy, she said. And despite the fatty acid's reputation as a health ...
Source: Science - The Huffington Post - October 14, 2015 Category: Science Source Type: news

Smoking behaviour and knowledge of the health effects of smoking in patients with inflammatory bowel disease
ConclusionAlthough patients with Crohn's disease were better informed on the detrimental effects of smoking, the awareness rate was still low.
Source: Alimentary Pharmacology and Therapeutics - October 5, 2015 Category: Drugs & Pharmacology Authors: C. De Bie, V. Ballet, N. Hendriks, S. Coenen, E. Weyts, G. Van Assche, S. Vermeire, M. Ferrante Tags: Original Scientific Paper Source Type: research

Mortality and comorbidities in patients with multiple sclerosis compared with a population without multiple sclerosis: An observational study using the US department of defense administrative claims database
Conclusions Rates of mortality and several comorbidities are higher in the MS versus non-MS cohort. Early recognition and management of comorbidities may reduce premature mortality and improve quality of life in patients with MS.
Source: Multiple Sclerosis and Related Disorders - August 19, 2015 Category: Neurology Source Type: research

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