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Genes That Extend Lifespan May Do So by Mitigating the Increased Risk of Death Posed by Having Hypertension
Am J Hypertens. 2023 Aug 10:hpad070. doi: 10.1093/ajh/hpad070. Online ahead of print.ABSTRACTGenetic factors influence lifespan. In humans, there appears to be a particularly strong genetic effect in those aged ≥ 90 years. An important contribution is nutrient sensing genes which confer cell resilience. Our research has been investigating the genetic factors by longitudinal studies of American men of Japanese descent living on the island of Oahu in Hawaii. This cohort began as the Honolulu Heart Program in the mid-1960s and most subjects are now deceased. We previously discovered various genes containing polymorphisms as...
Source: American Journal of Hypertension - August 10, 2023 Category: Cardiology Authors: Brian J Morris Timothy A Donlon Source Type: research

Risk and population attributable fraction of stroke subtypes in Japan
CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.PMID:37460296 | DOI:10.2188/jea.JE20220364
Source: Journal of Epidemiology - July 17, 2023 Category: Epidemiology Authors: Hiroshi Yatsuya Kazumasa Yamagishi Yuanying Li Isao Saito Yoshihiro Kokubo Isao Muraki Manami Inoue Shoichiro Tsugane Hiroyasu Iso Norie Sawada Source Type: research

Associations of Plasma 25-Hydroxy Vitamin D and Dietary Vitamin D Intake with Insulin Resistance in Healthy Japanese Women
J Nutr Sci Vitaminol (Tokyo). 2023;69(1):46-52. doi: 10.3177/jnsv.69.46.ABSTRACTWe investigated the associations of plasma 25-hydroxy vitamin D (25(OH)D) concentration and the dietary intake of vitamin D with insulin resistance in Japanese women. Study participants were 406 Japanese women attended a health examination. They were not taking hormones or medications for diabetes and had no history of cancer, ischemic heart disease, or stroke. Information regarding medical history and lifestyle factors was obtained by a self-administered questionnaire, while hours of sun exposure were determined through interviews. Dietary int...
Source: Journal of Nutritional Science and Vitaminology - March 1, 2023 Category: Nutrition Authors: Sachi Koda Keiko Wada Michiyo Yamakawa Yuma Nakashima Makoto Hayashi Noriyuki Takeda Keigo Yasuda Chisato Nagata Source Type: research

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