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Total 1014 results found since Jan 2013.
Insulin Regulation of Hepatic Lipid Homeostasis
Compr Physiol. 2023 Jun 26;13(3):4785-4809. doi: 10.1002/cphy.c220015.ABSTRACTThe incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise worldwide. The liver is a central insulin-responsive metabolic organ that governs whole-body metabolic homeostasis. Therefore, defining the mechanisms underlying insulin action in the liver is essential to our understanding of the pathogenesis of insulin resistance. During periods of fasting, the liver catabolizes fatty acids and stored glycogen to meet the metabolic demands of the body. In postprandial conditions, insulin signals to the liver to store exc...
Source: Comprehensive Physiology - June 26, 2023 Category: Physiology Authors: Kahealani Uehara Dominic Santoleri Anna E Garcia Whitlock Paul M Titchenell Source Type: research
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis
Hum Reprod Update. 2023 Jun 23:dmad015. doi: 10.1093/humupd/dmad015. Online ahead of print.ABSTRACTBACKGROUND: Current knowledge about the consequences of PCOS during the late reproductive years and after menopause is limited.OBJECTIVE AND RATIONALE: We performed a systematic review and meta-analysis of data on the pathophysiology, clinical manifestations, diagnosis, prognosis, and treatment of women ≥45 years of age-peri- or postmenopausal-with PCOS.SEARCH METHODS: Studies published up to 15 April 2023, identified by Entrez-PubMed, EMBASE, and Scopus online facilities, were considered. We included cross-sectional or pro...
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Mercedes Mill án-de-Meer Manuel Luque-Ram írez L ía Nattero-Chávez H éctor F Escobar-Morreale Source Type: research
Metabolic syndrome and osteoarthritis: implications for the management of an increasingly common phenotype
Metabolic syndrome is an accumulation of three or more seemingly benign and relatively common conditions (central obesity, hypertension, raised triglycerides, low HDL-cholesterol, glucose intolerance) that, together, increase the risk of developing serious chronic disease.1 It is estimated that one-quarter of adults worldwide have metabolic syndrome2 — a concerning statistic considering that this population is five times more likely to develop diabetes, and two-to-three times more likely to develop heart disease, stroke, and certain cancers.
Source: Osteoarthritis and Cartilage - June 20, 2023 Category: Rheumatology Authors: Casey L Peiris, Adam G Culvenor Tags: Editorial Source Type: research
7 Myths About Cholesterol, Debunked
You may not recall every lab value from your last physical, but you probably remember one: Your cholesterol level.
If it’s higher than ideal, you’re not alone. According to the U.S. Centers for Disease Control and Prevention, between 2015 and 2018, almost 12% of U.S. adults ages 20 and up had high total cholesterol, defined as above 240 mg/dL. The type that physicians mostly worry about is LDL (or “bad”) cholesterol, which is one component of that total.
Why do doctors care so much about cholesterol? First, “it predicts risk,” says Dr. Jeffrey Berger, a cardiologist and director of the C...
Source: TIME: Health - June 19, 2023 Category: Consumer Health News Authors: Katherine Hobson Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news
Artificially sweetened beverages and health outcomes: an umbrella review
CONCLUSIONS: The consumption of ASBs was associated with a higher risk of obesity, type II diabetes, all-cause mortality, hypertension, and cardiovascular disease incidence. However, further cohort studies and clinical trials in humans are still needed to understand the impact of ASBs on health outcomes.PMID:37187453 | DOI:10.1016/j.advnut.2023.05.010
Source: Adv Data - May 15, 2023 Category: Epidemiology Authors: Cristina Diaz Leandro F M Rezende Angelo Sabag Dong Hoon Lee Gerson Ferrari Edward L Giovannucci Juan Pablo Rey-Lopez Source Type: research
Mental Health and Quality of Life in Pulmonary Embolism: A Literature Review
Adv Respir Med. 2023 Apr 20;91(2):174-184. doi: 10.3390/arm91020015.ABSTRACTPulmonary embolismis an acute disease with chronic complications and, although it is not considered a chronic disease, it requires close follow-up. The scope of the present literature review is to decode the existing data concerning quality of life and the mental health impact of PE during the acute and long-term phases of the disease. The majority of studies reported impaired quality of life in patients with PE when compared to population norms, both in the acute phase and >3 months after PE. Quality of life improves over time, irrespectively o...
Source: Adv Data - April 27, 2023 Category: Epidemiology Authors: Niki Gkena Paraskevi Kirgou Konstantinos I Gourgoulianis Foteini Malli Source Type: research
Network Structure of Comorbidity Patterns in U.S. Adults with Depression: A National Study Based on Data from the Behavioral Risk Factor Surveillance System
CONCLUSION: Associations between chronic conditions were reported; furthermore, they were grouped into 3 latent dimensions of comorbidity and reported network factor loadings. The implementation of care and treatment guidelines and protocols for patients with depressive symptomatology and multimorbidity is suggested.PMID:37096248 | PMC:PMC10122603 | DOI:10.1155/2023/9969532
Source: Depression Research and Treatment - April 25, 2023 Category: Psychiatry Authors: Cristian Ramos-Vera Antonio Serpa Barrientos Jos é Vallejos-Saldarriaga Yaquelin E Calizaya-Milla Jacksaint Saintila Source Type: research
