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Total 61743 results found since Jan 2013.
Quality consistency evaluation of chemical composition and pharmacology of Shaoyao-Gancao decoction dispensing granules and traditional decoction
This study presents a method for evaluating the quality consistency of DGCM and TD of SGD, offering novel insights into the evaluation of consistency between DGCM and TD.PMID:37736670 | DOI:10.1002/bmc.5745
Source: Biomedical Chromatography : BMC - September 22, 2023 Category: Biomedical Science Authors: Fengyu Dong Mengdi Xie Manwen Xu Lu Lu Yan Miao Panpan Zhang Xiaopeng Li Xinjing Gui Ruixin Liu Source Type: research
Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma
Aging (Albany NY). 2023 Sep 21;15. doi: 10.18632/aging.205052. Online ahead of print.ABSTRACTGlioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite standard treatments. This investigation aimed to explore the feasibility of PTPN6 to combat GBM with immunotherapy. Our study employed a comprehensive analysis of publicly available datasets and functional experiments to assess PTPN6 gene expression, prognostic value, and related immune characteristics in glioma. We evaluated the influence of PTPN6 expression on CD8+ T cell exhaustion, immune suppression, and tumor growth in human GBM samples and mo...
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Xiaonan Zhang Jie Chen Ming Zhang Saisai Liu Tao Wang Tianyu Wu Baiqing Li Shidi Zhao Hongtao Wang Li Li Chun Wang Li Huang Source Type: research
The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
In conclusion, our findings reveal the mechanism of tumorigenic miR-429 in TNBC, which paves the way for target therapies translation in clinical settings.PMID:37737712 | DOI:10.18632/aging.205051
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Yao Li Xue Meng Yuqing Luo Shuai Luo Jin Li Jiafei Zeng Xiang Huang Jinjing Wang Source Type: research
Prognosis and immunoinfiltration analysis of angiogene-related genes in grade 4 diffuse gliomas
Aging (Albany NY). 2023 Sep 21;15. doi: 10.18632/aging.205054. Online ahead of print.ABSTRACTAlthough angiogenesis critically influences the progression of solid tumors, its contribution to highly malignant, grade 4 diffuse gliomas remains unclear. After analyzing 506 angiogenesis-related genes differentially expressed in grade 4 diffuse gliomas via LASSO and univariate and multivariate COX regression analyses, we constructed a nomogram based on COL22A1, IGFBP2, and MPO that accurately predicted patient survival. The nomogram's performance was validated in an external patient cohort, and a risk score based on the formula C...
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Hui Liu Zhirui Zeng Peng Sun Source Type: research
A novel risk model of three gefitinib-related genes FBP1, SBK1 and AURKA is related to the immune microenvironment and is predicting prognosis of lung adenocarcinoma patients
CONCLUSION: FBP1, SBK1, and AURKA are prognostic risk factors, and the risk model and nomogram of FBP1, SBK1 and AURKA are associated with dismal prognosis and immune cell infiltration, and have huge prospects for application in evaluating the prognosis in LUAD.PMID:37737707 | DOI:10.18632/aging.205040
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Qiang Guo Kai Li Ni Jiang Rui Zhou Xin-Rui Rao Chuang-Yan Wu Source Type: research
Internet search analysis on the treatment of rheumatoid arthritis: What do people ask and read online?
ConclusionsThe questions were most frequently related to the timeline of treatment and clinical course. Physicians should provide such information to patients with RA in the counseling and education materials.
Source: PLoS One - September 22, 2023 Category: Biomedical Science Authors: Satoshi Yamaguchi Source Type: research
Integrated network pharmacology and metabolomics analyses of the mechanism underlying the efficacy of Ma-Mu-Ran Antidiarrheal Capsules against dextran sulfate sodium-induced ulcerative colitis
In this study, we established a mouse model of UC using dextran sulfate sodium. Colonic tissues were collected from mice and then subjected to hematoxylin and eosin staining, as well as histopathological analysis, to assess the therapeutic effect of MMRAC. Furthermore, we assessed the mechanisms through which MMRAC combats UC by employing integrated metabolomics and network pharmacology strategies. Lastly, we validated the key targets identified through western blot and molecular docking. An integrated network of metabolomics and network pharmacology was constructed using Cytoscape to identify eight endogenous metabolites ...
Source: Biomedical Chromatography : BMC - September 21, 2023 Category: Biomedical Science Authors: Hailing Huang Bailu Duan Sili Zheng Yan Ye Dongning Zhang Zhuang Huang Shanshan Wang Fengyun Zhang Ping Huang Fang Huang Lintao Han Source Type: research
A novel model for eggs like pears: How to quantify them geometrically with a mathematical formula of two parameters?
J Biosci. 2023;48:35.ABSTRACTOf the variety of bird egg shapes, perhaps the most fascinating and unusual are pyriform (pear-shaped, or conical) eggs. Among oologists, there is still no consensus on what exactly caused this evolutionary and ecological adaptation. To address this, our research was aimed to develop a minimalistic mathematical model for an accurate description of the pyriform egg contour, using the minimum number of measurements. As such, egg length (L) and its maximum breadth (B) were found to be an optimal set of parameters that were easy enough to measure with the required accuracy. We tested four analytica...
Source: Journal of Biosciences - September 21, 2023 Category: Biomedical Science Authors: Valeriy G Narushin Michael N Romanov Darren K Griffin Source Type: research
A new look at an old problem: 3D modeling of accommodation reveals how age-related biomechanical changes contribute to dysfunction in presbyopia
Biomech Model Mechanobiol. 2023 Sep 21. doi: 10.1007/s10237-023-01767-6. Online ahead of print.ABSTRACTPresbyopia is an age-related ocular disorder where accommodative ability declines so that an individual's focusing range is insufficient to provide visual clarity for near and distance vision tasks without corrective measures. With age, the eye exhibits changes in biomechanical properties of many components involved in accommodation, including the lens, sclera, and ciliary muscle. Changes occur at different rates, affecting accommodative biomechanics differently, but individual contributions to presbyopia are unknown. We ...
Source: Biomechanics and Modeling in Mechanobiology - September 21, 2023 Category: Biomedical Science Authors: Katherine R Knaus AnnMarie Hipsley Silvia S Blemker Source Type: research
Association between electronic nicotine delivery systems use and risk of stroke: a meta-analysis of 1,024,401 participants
CONCLUSIONS: The ENDS usage appears to be associated with a higher risk of stroke compared to non-use, whereas there was no association between former ENDS use and the risk of stroke.PMID:37732043 | PMC:PMC10507757 | DOI:10.5114/aoms/171473
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Kamal Awad Maged Mohammed Seth S Martin Maciej Banach Source Type: research
Pan-cancer analysis and experimental validation identify ndc1 as a potential immunological, prognostic and therapeutic biomarker in pancreatic cancer
Aging (Albany NY). 2023 Sep 20;15. doi: 10.18632/aging.205048. Online ahead of print.ABSTRACTNDC1 is a transmembrane nucleoporin that participates in cell mitosis. In the field of oncology, NDC1 has shown its potential as a prognostic marker for multiple tumors. However, pan-cancer analysis of NDC1 to fully explore its role in tumors has not been performed and little is reported on its role in pancreatic cancers. In the present study, a pan-cancer analysis of NDC1 was performed using a bioinformatic approach. Survival analysis was performed by univariate Cox regression analysis and Kaplan-Meier survival analysis. Subsequen...
Source: Aging - September 21, 2023 Category: Biomedical Science Authors: Qian Shen Junchen Li Chuanlong Zhang Xue Pan Yi Li Xiyuan Zhang Ge'er En Bo Pang Source Type: research
Heart rate variability: a predictor of cognitive decline
Aging (Albany NY). 2023 Sep 20;15. doi: 10.18632/aging.204715. Online ahead of print.NO ABSTRACTPMID:37733678 | DOI:10.18632/aging.204715
Source: Aging - September 21, 2023 Category: Biomedical Science Authors: Paola Nicolini Tiziano Lucchi Marco Vicenzi Source Type: research
Prognostic significance of < em > CTNNB1 < /em > mutation in hepatocellular carcinoma: a systematic review and meta-analysis
CONCLUSIONS: CTNNB1 mutation can serve as an indicator of favorable prognosis as well as a novel target for treatment in HCC.PMID:37733676 | DOI:10.18632/aging.205047
Source: Aging - September 21, 2023 Category: Biomedical Science Authors: Genlin Lu Jian Lin Guoqiang Song Min Chen Source Type: research
Astragalus polysaccharide inhibits the development of urothelial carcinoma by activating AMPK signaling to induce BENC1-xCT complex formation
Aging (Albany NY). 2023 Sep 20;15. doi: 10.18632/aging.205007. Online ahead of print.ABSTRACTIn recent years, the incidence of urothelial carcinoma (UC) has been high in men. The aim of this study was to investigate whether astragalus polysaccharide (APS) could inhibit the development of UC and the specific molecular mechanism. Our data showed that APS inhibited the proliferation of UC cells in a dose-dependent manner, and APS reduced the migratory capacity of RT4 and T24 cells. Further studies revealed that the ferroptosis inhibitor ferrostatin-1 (Fer-1) reversed APS-induced cell death, intracellular Fe2+ and malondialdeh...
Source: Aging - September 21, 2023 Category: Biomedical Science Authors: Guangquan Tong Xiaowei Wang Shuangfeng Chen Yanyang Jin Source Type: research
Beyond amyloid: altered gene function in neurodegenerative diseases
Aging (Albany NY). 2023 Sep 20;15. doi: 10.18632/aging.204717. Online ahead of print.NO ABSTRACTPMID:37733660 | DOI:10.18632/aging.204717
Source: Aging - September 21, 2023 Category: Biomedical Science Authors: Metin Yesiltepe Tao Yin Luciano D'Adamio Source Type: research
