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Source: Journal of Southern Medical University

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Total 14325 results found since Jan 2013.

Expression changes of Na < sub > V < /sub > channel subunits correlate with developmental maturation of electrophysiological characteristics of rat cerebellar Purkinje neurons
CONCLUSION: The changes in the expression levels of NaV subunits are correlated with the maturation of high frequency electrophysiological properties of the neurons, suggesting thatmature NaV subunit expressions is the basis of maturation of electrophysiological characteristics of the neurons.PMID:37488792 | PMC:PMC10366519 | DOI:10.12122/j.issn.1673-4254.2023.07.06
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: M Fu X Ji L Zhong Q Wu H Li N Wang Source Type: research

< em > Naoluo Xintong < /em > Decoction activates caspase-1/Gasdermin D pathway to promote angiogenesis of rat brain microvascular endothelial cells after oxygen glucose deprivation/reperfusion injury
CONCLUSION: NLXTD can improve the proliferation, migration, and tube- forming ability and promote angiogenesis of BMECs with OGD/R injury probably by inhibiting the caspase-1/Gasdermin D pathway in pyroptosis, alleviating cell injury, and upregulating the expressions of VEGF and VEGFR2.PMID:37488791 | PMC:PMC10366515 | DOI:10.12122/j.issn.1673-4254.2023.07.05
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: P Li Y Hu J Liu L Wang Y Wu J Hu Source Type: research

MiR-30e-5p overexpression promotes proliferation and migration of colorectal cancer cells by activating the CXCL12 axis < em > via < /em > downregulating PTEN
CONCLUSION: Overexpression of miR-30e-5p promotes the malignant behaviors of colorectal cancer cells by downregulating PTEN to activate the CXCL12 axis.PMID:37488790 | PMC:PMC10366527 | DOI:10.12122/j.issn.1673-4254.2023.07.04
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: K Wei J Shi Y Xiao W Wang Q Yang C Chen Source Type: research

Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells
CONCLUSION: PLEKHA4 knockdown inhibited the proliferation of glioma cells and promoted apoptosis by inhibiting the activation of the MAPK signaling pathway and expression of β-catenin. Lactic acid produced by glycolysis upregulates the expression of PLEKHA4 in glioma cells.PMID:37488789 | PMC:PMC10366507 | DOI:10.12122/j.issn.1673-4254.2023.07.03
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: J Ye W Xu B Xi N Wang T Chen Source Type: research

High expression of death-associated protein 5 promotes glucose metabolism in gastric cancer cells and correlates with poor survival outcomes
CONCLUSION: A high expression of DAP5 in GC, which enhances cellular aerobic glycolysis to promote cancer progression, is correlated with a poor survival outcome and may serve as a biomarker for evaluating long-term prognosis of GC patients.PMID:37488788 | PMC:PMC10366509 | DOI:10.12122/j.issn.1673-4254.2023.07.02
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: Q Wang Z Zhang L Wang Y Wang X Yao Y Wang X Zhang S Ge L Zuo Source Type: research

Analysis of therapeutic mechanism of < em > Liushen Wan < /em > against colitis-associated colorectal cancer based on network pharmacology and validation in mice
CONCLUSION: LSW can inhibit CAC in mice possibly by regulating the expression of TLR4 to reduce intestinal inflammation, inhibit colon tumor cell proliferation and promote their apoptosis.PMID:37488787 | PMC:PMC10366510 | DOI:10.12122/j.issn.1673-4254.2023.07.01
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: X Zhang Y Chen Z Li J Shang Z Yuan W Deng Y Luo N Han P Yin J Yin Source Type: research

Feasibility and safety of one-stage bilateral video-assisted thoracic surgery for resection of bilateral multiple pulmonary nodules
CONCLUSION: With appropriate preoperative screening and perioperative management, one-stage bilateral VATS is feasible and safe for resection of BMPNs.PMID:37488809 | PMC:PMC10366508 | DOI:10.12122/j.issn.1673-4254.2023.07.23
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: S Zhang Y Zhao A Zhou H Liu M Zheng Source Type: research

Puerarin alleviates lipopolysaccharide-induced acute kidney injury in mice by modulating the SIRT1/NF- κB pathway
CONCLUSION: Puerarin can effectively alleviate LPS-induced AKI in mice possibly by modulating the SIRT1/NF-κB signaling pathway.PMID:37488808 | PMC:PMC10366522 | DOI:10.12122/j.issn.1673-4254.2023.07.22
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: J Guo W Zhang P Liang L Zhang L Peng Y Min X Pan Z Yang H Deng Source Type: research

An interpretable machine learning-based prediction model for risk of death for patients with ischemic stroke in intensive care unit
CONCLUSION: This EBM model has a good performance for predicting the risk of death within one year in patients with severe ischemic stroke and allows clinicians to better understand the contributing factors of the patients' outcomes through the model interpretability.PMID:37488807 | PMC:PMC10366517 | DOI:10.12122/j.issn.1673-4254.2023.07.21
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: X Luo Y Cheng C Wu J He Source Type: research

A method for sensitivity analysis of deviation factor for geometric correction of cone-beam CT system
CONCLUSION: The geometric correction is more sensitive to the deviation generated by the three-dimensional spatial coordinates of the steel ball point with limited sensitivity to the deviation generated by the two-dimensional projection coordinates of the steel ball point. The deviation sensitivity of a small diameter steel ball point can be ignored.PMID:37488806 | PMC:PMC10366513 | DOI:10.12122/j.issn.1673-4254.2023.07.20
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: H Wang G Lin X Duan M Qi W Wu J Ma Y Xu Source Type: research

Diffusion tensor field estimation based on 3D U-Net and diffusion tensor imaging model constraint
CONCLUSION: The proposed method can obtain accurate DTI quantification parameters from one non-DW image and 6 DW images to reduce image acquisition time and improve the reliability of quantitative diagnosis.PMID:37488805 | PMC:PMC10366516 | DOI:10.12122/j.issn.1673-4254.2023.07.19
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: Z Mai J Li Y Feng X Zhang Source Type: research

Sinogram interpolation combined with unsupervised image-to-image translation network for CT metal artifact correction
CONCLUSION: The proposed method for metal artifact correction can effectively remove metal artifacts, improve image quality, and preserve more details and structures on CT images.PMID:37488804 | PMC:PMC10366526 | DOI:10.12122/j.issn.1673-4254.2023.07.18
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: J Yu K Zhang S Jin Z Su X Xu H Zhang Source Type: research

Value of Improved Mayo Endoscopic Score for evaluating treatment efficacy for active ulcerative colitis
CONCLUSION: IMES has good value in evaluating treatment efficacy for active UC.PMID:37488803 | PMC:PMC10366518 | DOI:10.12122/j.issn.1673-4254.2023.07.17
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: Z Song H Dong N Ma Y Ren B Jiang Source Type: research

An improved 4-vessel intermittent occlusion method for establishing rat models of global cerebral ischemia-reperfusion injury
CONCLUSION: The improved 4VO model can successfully mimic the main pathological processes of global cerebral ischemia-reperfusion injury without causing visual impairment in rats.PMID:37488802 | PMC:PMC10366505 | DOI:10.12122/j.issn.1673-4254.2023.07.16
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: W Sun P Chen X Tang Y Gu X Tian Source Type: research

STIP1 correlates with tumor immune infiltration and prognosis as a potential immunotherapy target: a pan-cancer bioinformatics analysis
CONCLUSION: STIP1 is up-regulated in multiple cancer types and its expression level is correlated with clinical tumor stage, tumor mutational burden, microsatellite instability, immune cell infiltration and immunomodulatory factors.PMID:37488801 | PMC:PMC10366520 | DOI:10.12122/j.issn.1673-4254.2023.07.15
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: S Guan Z Shen M Lin H Deng Y Fang Source Type: research