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Source: Journal of Southern Medical University
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Total 14325 results found since Jan 2013.
STIP1 correlates with tumor immune infiltration and prognosis as a potential immunotherapy target: a pan-cancer bioinformatics analysis
CONCLUSION: STIP1 is up-regulated in multiple cancer types and its expression level is correlated with clinical tumor stage, tumor mutational burden, microsatellite instability, immune cell infiltration and immunomodulatory factors.PMID:37488801 | PMC:PMC10366520 | DOI:10.12122/j.issn.1673-4254.2023.07.15
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: S Guan Z Shen M Lin H Deng Y Fang Source Type: research
Characterization of metabotropic glutamate receptor 7 and 8 in rat superior cervical ganglion and their changes following chronic intermittent hypoxia
CONCLUSION: mGluR7 and mGluR8 are present in rat SCG but with different localization patterns. CIH increases blood pressure of rats and enhanced protein expressions of mGluR7 and mGluR8 in rat SCG.PMID:37488800 | PMC:PMC10366511 | DOI:10.12122/j.issn.1673-4254.2023.07.14
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: X Wei C Li C Zhao B Zhao Y Liu Source Type: research
LRG1 inhibits hepatic macrophage activation by enhancing TGF- β1 signaling to alleviate MAFLD in mice
CONCLUSION: LRG1 inhibits hepatic macrophage infiltration by enhancing TGF-β1 signaling to alleviate fatty liver inflammation in MAFLD mice.PMID:37488799 | PMC:PMC10366524 | DOI:10.12122/j.issn.1673-4254.2023.07.13
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: L Xu J Han Z Yang Y Yang J Chen X Wu Q Wang Y Hong Source Type: research
Effect of < em > Porphyromonas < /em > < em > gingivalis < /em > infection on IFNGR1 palmitoylation in esophageal cancer cells
CONCLUSION: Pg infection enhances IFNGR1 palmitoylation to promote progression of ESCC, and elimination of Pg and inhibiting IFNGR1 palmitoylation may effectively control ESCC progression.PMID:37488798 | PMC:PMC10366523 | DOI:10.12122/j.issn.1673-4254.2023.07.12
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: L Shen D Zhang S Gao Source Type: research
Protective effects of total saponins from < em > Panax < /em > < em > japonicus < /em > against high-fat diet-induced testicular Sertoli cell junction damage in mice
CONCLUSION: TSPJ alleviates high-fat diet-induced damages of testicular Sertoli cell junctions and spermatogenesis possibly by activating the AKT/mTOR signaling pathway and inhibiting autophagy of testicular Sertoli cells.PMID:37488797 | PMC:PMC10366514 | DOI:10.12122/j.issn.1673-4254.2023.07.11
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: B Zhou C Zhang H Deng S Chen Y Chang Y Yang G Fu D Yuan H Zhao Source Type: research
Inhibitor of growth protein-2 silencing alleviates angiotensin Ⅱ-induced cardiac remodeling in mice by reducing p53 acetylation
CONCLUSION: Ing2 silencing can inhibit AngⅡ-induced cardiac remodeling and dysfunction in mice by reducing p53 acetylation.PMID:37488795 | PMC:PMC10366506 | DOI:10.12122/j.issn.1673-4254.2023.07.09
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: Z Liu X Qiu H Yang X Wu W Ye Source Type: research
Procine recombinant NK-lysin inhibits hepatocellular carcinoma metastasis by downregulating FKBP3 and inhibiting oxidative phosphorylation and glycolysis: a proteomic analysis
CONCLUSION: Treatment with prNK-lysin causes significant changes in protein expression profile of SMMOL/LC-7721 cells and inhibits hepatocellular carcinoma metastasis by downregulating FKBP3 protein and affecting the cellular oxidative phosphorylation and glycolysis pathways.PMID:37488794 | PMC:PMC10366521 | DOI:10.12122/j.issn.1673-4254.2023.07.08
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: Y Fan Z Feng K Fan W Yin N Sun P Sun Y Sun H Li Source Type: research
UhpT < sup > E350Q < /sup > mutation along with the presence of < em > fosA6/5 < /em > genes in the genome probably contributes to inherent fosfomycin resistance of < em > Klebsiella pneumoniae < /em >
CONCLUSION: UhpTE350Q mutation with the presence of fosA6/5 genes are ubiquitous in K. pneumonia genomes, indicating a possible intrinsic mechanism of fosfomycin resistance in the bacterium to limit the use of fosfomycin against infections caused by K. pneumoniae, especially the multi-resistant HvKP/HmKP strains.PMID:37488793 | PMC:PMC10366525 | DOI:10.12122/j.issn.1673-4254.2023.07.07
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: R DA Y Zhou Y Cheng J Lv B Han Source Type: research
Expression changes of Na < sub > V < /sub > channel subunits correlate with developmental maturation of electrophysiological characteristics of rat cerebellar Purkinje neurons
CONCLUSION: The changes in the expression levels of NaV subunits are correlated with the maturation of high frequency electrophysiological properties of the neurons, suggesting thatmature NaV subunit expressions is the basis of maturation of electrophysiological characteristics of the neurons.PMID:37488792 | PMC:PMC10366519 | DOI:10.12122/j.issn.1673-4254.2023.07.06
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: M Fu X Ji L Zhong Q Wu H Li N Wang Source Type: research
< em > Naoluo Xintong < /em > Decoction activates caspase-1/Gasdermin D pathway to promote angiogenesis of rat brain microvascular endothelial cells after oxygen glucose deprivation/reperfusion injury
CONCLUSION: NLXTD can improve the proliferation, migration, and tube- forming ability and promote angiogenesis of BMECs with OGD/R injury probably by inhibiting the caspase-1/Gasdermin D pathway in pyroptosis, alleviating cell injury, and upregulating the expressions of VEGF and VEGFR2.PMID:37488791 | PMC:PMC10366515 | DOI:10.12122/j.issn.1673-4254.2023.07.05
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: P Li Y Hu J Liu L Wang Y Wu J Hu Source Type: research
MiR-30e-5p overexpression promotes proliferation and migration of colorectal cancer cells by activating the CXCL12 axis < em > via < /em > downregulating PTEN
CONCLUSION: Overexpression of miR-30e-5p promotes the malignant behaviors of colorectal cancer cells by downregulating PTEN to activate the CXCL12 axis.PMID:37488790 | PMC:PMC10366527 | DOI:10.12122/j.issn.1673-4254.2023.07.04
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: K Wei J Shi Y Xiao W Wang Q Yang C Chen Source Type: research
Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells
CONCLUSION: PLEKHA4 knockdown inhibited the proliferation of glioma cells and promoted apoptosis by inhibiting the activation of the MAPK signaling pathway and expression of β-catenin. Lactic acid produced by glycolysis upregulates the expression of PLEKHA4 in glioma cells.PMID:37488789 | PMC:PMC10366507 | DOI:10.12122/j.issn.1673-4254.2023.07.03
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: J Ye W Xu B Xi N Wang T Chen Source Type: research
High expression of death-associated protein 5 promotes glucose metabolism in gastric cancer cells and correlates with poor survival outcomes
CONCLUSION: A high expression of DAP5 in GC, which enhances cellular aerobic glycolysis to promote cancer progression, is correlated with a poor survival outcome and may serve as a biomarker for evaluating long-term prognosis of GC patients.PMID:37488788 | PMC:PMC10366509 | DOI:10.12122/j.issn.1673-4254.2023.07.02
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: Q Wang Z Zhang L Wang Y Wang X Yao Y Wang X Zhang S Ge L Zuo Source Type: research
Analysis of therapeutic mechanism of < em > Liushen Wan < /em > against colitis-associated colorectal cancer based on network pharmacology and validation in mice
CONCLUSION: LSW can inhibit CAC in mice possibly by regulating the expression of TLR4 to reduce intestinal inflammation, inhibit colon tumor cell proliferation and promote their apoptosis.PMID:37488787 | PMC:PMC10366510 | DOI:10.12122/j.issn.1673-4254.2023.07.01
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: X Zhang Y Chen Z Li J Shang Z Yuan W Deng Y Luo N Han P Yin J Yin Source Type: research
Feasibility and safety of one-stage bilateral video-assisted thoracic surgery for resection of bilateral multiple pulmonary nodules
CONCLUSION: With appropriate preoperative screening and perioperative management, one-stage bilateral VATS is feasible and safe for resection of BMPNs.PMID:37488809 | PMC:PMC10366508 | DOI:10.12122/j.issn.1673-4254.2023.07.23
Source: Journal of Southern Medical University - July 25, 2023 Category: Universities & Medical Training Authors: S Zhang Y Zhao A Zhou H Liu M Zheng Source Type: research
