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Regulation of Corticosteroidogenic Genes by MicroRNAs.
This study demonstrates that corticosteroidogenesis is regulated at multiple points by several microRNAs and that certain of these microRNAs are differentially expressed in tumorous adrenal tissue, which may contribute to dysregulation of corticosteroid secretion. These findings provide new insights into the regulation of corticosteroid production and have implications for understanding the pathology of disease states where abnormal hormone secretion is a feature. PMID: 28852406 [PubMed]
Source: International Journal of Endocrinology - September 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor null mice: informing cell-type-specific roles
The mineralocorticoid receptor (MR) mediates the actions of two important adrenal corticosteroid hormones, aldosterone and cortisol. The cell signalling roles of the MR in vivo have expanded enormously since the cloning of human MR gene 30 years ago and the first MR gene knockout in mice nearly 20 years ago. Complete ablation of the MR revealed important roles postnatally for regulation of kidney epithelial functions, with MR-null mice dying 1–2 weeks postnatally from renal salt wasting and hyperkalaemia, with elevated plasma renin and aldosterone. Generation of tissue-selective MR-deficient mice using Cre recombinas...
Source: Journal of Endocrinology - June 20, 2017 Category: Endocrinology Authors: Cole, T. J., Young, M. J. Tags: Thematic Review Source Type: research

Inactivation of histone deacetylase 1 (hdac1) but not hdac2 is required for the glucocorticoid-dependent ccaat/enhancer binding protein α (c/ebpα) expression and preadipocyte differentiation.
In this study, we sought to demonstrate using two different strategies the definite role of HDACl in adipogenesis. By using siRNA-mediated knockdown of HDAC1 and by generating an enzymatically inactive HDAC1D181A by site-directed mutagenesis, we were able to show that HDAC1, but not HDAC2, suppresses GR-potentiated preadipocyte differentiation by decreasing C/ebpα and Pparγ expression levels at the onset of differentiation. Finally, we demonstrate that HDAC1D181A acts as a dominant negative mutant of HDACl during adipogenesis by modulating C/EBPβ transcriptional activity on the C/ebpα promoter. PMID: 25203139 [Pub...
Source: Endocrinology - September 9, 2014 Category: Endocrinology Authors: Kuzmochka C, Abdou HS, Haché RJ, Atlas E Tags: Endocrinology Source Type: research

Enhancement of cell surface expression and receptor functions of membrane progestin receptor alpha (mPRα) by progesterone receptor membrane component 1 (PGRMC1): evidence for a role of PGRMC1 as an adaptor protein for steroid receptors.
Abstract A variety of functions have been proposed for progesterone receptor membrane component 1 (PGRMC1), including acting as a component of a membrane progestin receptor and as an adaptor protein. Here we show that stable over expression of human PGRMC1 in progesterone receptor-negative breast cancer cell lines causes increased expression of PGRMC1 and membrane progesterone receptor alpha (mPRα) on cell membranes which is associated with increased specific [(3)H]progesterone binding. The membrane progestin binding affinity and specificity were characteristic of mPRα, with a Kd of 4.7 nM and high affinity for ...
Source: Endocrinology - January 1, 2014 Category: Endocrinology Authors: Thomas P, Pang Y, Dong J Tags: Endocrinology Source Type: research