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Total 78 results found since Jan 2013.
Estrogen Receptor Alpha regulates ATM expression through miRNAs in breast cancer.
CONCLUSIONS: We reveal a novel mechanism involving ERα and miRNA 18a and 106a regulation of ATM in breast cancer.
PMID: 23857602 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - July 15, 2013 Category: Cancer & Oncology Authors: Guo X, Yang C, Qian X, Lei T, Li Y, Shen H, Fu L, Xu B Tags: Clin Cancer Res Source Type: research
Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
Abstract: Radiotherapy is routinely used for the treatment of lung cancer. However, the mechanisms underlying ionizing radiation (IR)-induced senescence and its role in lung cancer treatment are poorly understood. Here, we show that IR suppresses the proliferation of human non-small cell lung cancer (NSCLC) cells via an apoptosis-independent mechanism. Further investigations reveal that the anticancer effect of irradiation correlates well with IR-induced premature senescence, as evidenced by increased senescence-associated β-glactosidase (SA-β-gal) staining, decreased BrdU incorporation and elevated expression of p16INK4...
Source: Lung Cancer - May 20, 2013 Category: Cancer & Oncology Authors: Hongmei Luo, Caroline Yount, Hainan Lang, Aimin Yang, Ellen C. Riemer, Katherine Lyons, Kenneth N. Vanek, Gerard A. Silvestri, Bradley A. Schulte, Gavin Y. Wang Tags: Carcinogenesis and molecular biology Source Type: research
Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis
Abstract: Colorectal cancer is the leading cause of cancer-related mortality in the western world. It is also the third most common cancer diagnosed in both men and women in the United States with a recent estimate for new cases of colorectal cancer in the year 2012 being around 103,170. Various risk factors for colorectal cancer include life-style, diet, age, personal and family history, and racial and ethnic background. While a few cancers are certainly preventable but this does not hold true for colon cancer as it is often detected in its advanced stage and generally not diagnosed until symptoms become apparent. Despite...
Source: Critical Reviews in Oncology Hematology - October 24, 2012 Category: Cancer & Oncology Authors: Jayshree Mishra, Joseph Drummond, Sohel H. Quazi, Satya Sridhar Karanki, J.J. Shaw, Ben Chen, Narendra Kumar Source Type: research
