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The combination of baicalin with knockdown of miR148a gene suppresses cell viability and proliferation and induces the apoptosis and autophagy of human glioblastoma multiforme T98G and U87MG cells
CONCLUSION: The siRNA-induced miR148a mRNA knockdown in combination with baicalin may offer a novel therapeutic strategy to more effective control the growth of human GBM cells. Thus, knockdown of this gene in combination with baicalin inhibits proliferation (cell cycle arrest in S phase in T98G but not in U87MG cells), induces apoptosis and regulates autophagy in T98G and U87MG cells, but further studies urgently needed to confirm a positive phenomenon for the treatment of GBM.PMID:35761505 | DOI:10.2174/1389201023666220627144100
Source: Current Pharmaceutical Biotechnology - June 28, 2022 Category: Biotechnology Authors: Monika Paul-Samojedny Emilia Liduk Ma łgorzata Kowalczyk Paulina Borkowska Aleksandra Zieli ńska Renata Suchanek-Raif Jan Kowalski Source Type: research

KLF16 suppresses human glioma cell proliferation and tumourigenicity by targeting TFAM.
CONCLUSIONS: KLF16 is a key regulator of glioma cell proliferation by directly targeting TFAM. PMID: 29374989 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - January 31, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

TP53INP1 3'-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity.
CONCLUSIONS: TP53INP1 3'-UTR could inhibit the EMT, thus hindering the migration and invasion of glioma via acting as a ceRNA for E-cadherin. PMID: 27341836 [PubMed - as supplied by publisher]
Source: Biotechnology Letters - June 23, 2016 Category: Biotechnology Authors: Wang Y, Lin G Tags: Biotechnol Lett Source Type: research

Nucleic-Acid Delivery Using Lipid Nanocapsules.
In conclusion, LNCs are very good candidates to deliver nucleic acids to cells in the course of anti-cancer therapies. PMID: 27033510 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - March 31, 2016 Category: Biotechnology Authors: Lagarce F, Passirani C Tags: Curr Pharm Biotechnol Source Type: research

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