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A cationic amino acid polymer nanocarrier synthesized in supercritical CO < sub > 2 < /sub > for co-delivery of drug and gene to cervical cancer cells
Colloids Surf B Biointerfaces. 2022 May 18;216:112584. doi: 10.1016/j.colsurfb.2022.112584. Online ahead of print.ABSTRACTThe present study was undertaken to investigate the ability of a drug curcumin-loaded polymer to inhibit the growth of cervical cancer cells by enhancing the anti-cancer efficiency of curcumin. We synthesized poly(methacryloyl beta-alanine) (PMBA) as a nanocarrier by radical polymerization in supercritical CO2. The results showed that the curcumin encapsulated and folic acid (FA)-treated PMBA (Poly@Cur-FA) for 24 h activated the reactive oxygen species-mediated programmed cell death machinery in HeLa ce...
Source: Colloids and Surfaces - May 26, 2022 Category: Biotechnology Authors: K V Kavya Stella Vargheese Shruti Shukla Imran Khan Debasish Kumar Dey Vivek K Bajpai Kavitha Thangavelu Raju Vivek R T Rajendra Kumar Young-Kyu Han Yun Suk Huh Yuvaraj Haldorai Source Type: research

Transcriptome profiling of cervical cancer cells acquired resistance to cisplatin by deep sequencing.
In this study, we developed cisplatin resistance cell line, subsequently examined the molecular mechanisms linked. Transcriptome sequencing technology was utilized to compare the various expression models between the cisplatin-resistant cell line (Hela/DDP) and its parental cell line human cervical adenocarcinoma Hela. The present study has identified 2,312 differentially expressed genes (DEGs). Results showed there were 1,437 up-regulated genes and 875 down-regulated ones. Databases analysis including Gene ontology (GO), Cluster of Orthologous Groups of proteins (COG) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pat...
Source: Artificial Cells, Nanomedicine and Biotechnology - July 13, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

The combinational effect of E6/E7 siRNA and anti-miR-182 on apoptosis induction in HPV16-positive cervical cells.
Authors: Javadi H, Lotfi AS, Hosseinkhani S, Mehrani H, Amani J, Soheili ZS, Hojati Z, Kamali M Abstract In the present research, we assumed that reducing the amounts of E6 and E7 oncoproteins by a specific siRNA sequence and recovering p53 and RB proteins, along with the recovery of the FOXO1 protein by applying anti-miR-182, would increase apoptosis and reduce proliferation rate in cancer cells. The HPV16-positive CaSki cervical cancer cell line was used. 48 hours after transfection of siRNA for targeting E6 and E7 oncoproteins and anti-miR-182, expression of its cellular targets p53, p21 and FOXO1 was assessed...
Source: Artificial Cells, Nanomedicine and Biotechnology - June 7, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research