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miR-324-5p inhibits gallbladder carcinoma cell metastatic behaviours by downregulation of transforming growth factor beta 2 expression.
Authors: Zhang X, Zhang L, Chen M, Liu D Abstract Increasing studies have demonstrated that microRNAs (miRNAs) are associated with the metastasis of gallbladder carcinoma (GBC). Recently, miR-324-5p has been reported to be a tumour-suppressive miRNA in many types of malignant cancer. However, the biological function and molecular mechanism of miR-324-5p in GBC still remain largely unknown. Here, we found that miR-324-5p expression was notably down-regulated in both GBC tissues and cells compared with that in normal controls. Downregulated miR-324-5p expression was negatively associated with the status of local inva...
Source: Artificial Cells, Nanomedicine and Biotechnology - December 22, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Hyperglycemia aggravates microenvironment hypoxia and promotes the metastatic ability of pancreatic cancer
ConclusionOur results demonstrate that the association between hyperglycemia and poor prognosis can be attributed to microenvironment hypoxia in pancreatic cancer.Graphical Abstract
Source: Computational and Structural Biotechnology Journal - October 30, 2018 Category: Biotechnology Source Type: research

SiRNA-mediated silencing of Snail-1 induces apoptosis and alters micro RNA expression in human urinary bladder cancer cell line.
Authors: Musavi Shenas SM, Mansoori B, Mohammadi A, Salehi S, Kaffash B, Talebi B, Babaloo Z, Shanehbandi D, Baradaran B Abstract Snail-1 known as one of the important transcription factor is a mediator of survival and cell migration, and expression is raised in numerous cancer types. Snail-1 gene may show a role in recurrence of several cancers including bladder cancer by down-regulating E-cadherin, inducing an epithelial to mesenchymal transition (EMT) and its related microRNAs (miRNAs). The aim of this study was to investigate the effect of a specific Snail-1 siRNA on apoptosis and alter EMT related miRNAs of EJ...
Source: Artificial Cells, Nanomedicine and Biotechnology - June 22, 2016 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Retinoblastoma-binding protein 2 induces epithelial-mesenchymal transition in esophageal squamous cancer cells.
CONCLUSION: RBP2 could induce EMT in esophageal cancer cells and exert a greater effect on the expression of E-cadherin in lung squamous cells than in esophageal squamous cells. PMID: 26264242 [PubMed - as supplied by publisher]
Source: Biotechnology Letters - August 12, 2015 Category: Biotechnology Authors: Qiao N, Wang S, Hu L Tags: Biotechnol Lett Source Type: research