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Total 1790 results found since Jan 2013.
Acetyl-cinobufagin suppresses triple-negative breast cancer progression by inhibiting the STAT3 pathway
CONCLUSIONS: The findings of this study support the potential clinical use of acetyl-cinobufagin as a STAT3 inhibitor in TNBC adjuvant therapy.PMID:37651362 | DOI:10.18632/aging.204967
Source: Aging - August 31, 2023 Category: Biomedical Science Authors: Yufeng Qi Haodong Wu Tianru Zhu Zitian Liu Conghui Liu Congzhi Yan Zhixuan Wu Yiying Xu Ying Bai Lehe Yang Dezhi Cheng Xiaohua Zhang Haiyang Zhao Chengguang Zhao Xuanxuan Dai Source Type: research
Synchronous targeted delivery of TGF- β siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
Biomaterials. 2023 Jul 25;301:122253. doi: 10.1016/j.biomaterials.2023.122253. Online ahead of print.ABSTRACTThe poor permeability of therapeutic drugs, limited T-cell infiltration, and strong immunosuppressive tumor microenvironment of triple-negative breast cancer (TNBC) acts as a prominent barrier to the delivery of drugs and immunotherapy including programmed cell death ligand-1 antibody (anti-PD-L1). Transforming growth factor (TGF)-β, an important cytokine produced by cancer-associated fibroblasts (CAFs) and tumor cells contributes to the pathological vasculature, dense tumor stroma and strong immunosuppressive tumo...
Source: Biomaterials - August 3, 2023 Category: Materials Science Authors: Mengmeng Yang Chao Qin Linlin Tao Gang Cheng Jingjing Li Fangnan Lv Nan Yang Zuhang Xing Xinyu Chu Xiaopeng Han Meirong Huo Lifang Yin Source Type: research
Molecular landscape of LncRNAs in bladder cancer: From drug resistance to novel LncRNA-based therapeutic strategies
Biomed Pharmacother. 2023 Jul 31;165:115242. doi: 10.1016/j.biopha.2023.115242. Online ahead of print.ABSTRACTBladder cancer (BC) is a common and serious type of cancer that ranks among the top ten most prevalent malignancies worldwide. Due to the high occurrence rate of BC, the aggressive nature of cancer cells, and their resistance to medication, managing this disease has become a growing challenge in clinical care. Long noncoding RNAs (lncRNAs) are a group of RNA transcripts that do not code for proteins and are more than 200 nucleotides in length. They play a significant role in controlling cellular pathways and molecu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 2, 2023 Category: Drugs & Pharmacology Authors: Amirreza Mehmandar-Oskuie Kasra Jahankhani Arman Rostamlou Sepideh Arabi Zahra Sadat Razavi Amirhossein Mardi Source Type: research
Ultrasound-Mediated PLGA-PEI Nanobubbles Carrying STAT6 SiRNA Enhances NSCLC Treatment via Repolarizing Tumor-associated Macrophages from M2 to M1 Phenotypes
CONCLUSION: UMND enhanced PLGA-PEI NBs-STAT6 siRNA to repolarize TAMs from the M2 to the M1 phenotype, thus treating NSCLC. These findings provide a promising therapeutic approach for enhancing NSCLC immunotherapy.PMID:37491853 | DOI:10.2174/1567201820666230724151545
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hong Shu Wenhao Lv Zhi-Jian Ren Hui Li Tiantian Dong Yao Zhang Fang Nie Source Type: research
UCA1 executes an oncogenic role in pancreatic cancer by regulating miR-582-5p/BRCC3
ConclusionUCA1 acted as an oncogene in pancreatic cancer by partly regulating miR-582-5p/BRCC3, which could be a new therapeutic target for pancreatic cancer.
Source: Frontiers in Oncology - July 25, 2023 Category: Cancer & Oncology Source Type: research
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
CONCLUSIONS/INTERPRETATION: We provide the first account of epigenetic changes in diabetic corneas including dual inhibition of WNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.DATA AVAILABILITY: The DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328 ).PMID:37460827 | DOI:10.1007/s00125-023-05960-1
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Ruchi Shah Tanya M Spektor Daniel J Weisenberger Hui Ding Rameshwar Patil Cynthia Amador Xue-Ying Song Steven T Chun Jake Inzalaco Sue Turjman Sean Ghiam Jiho Jeong-Kim Sasha Tolstoff Sabina V Yampolsky Onkar B Sawant Yaron S Rabinowitz Ezra Maguen Pedram Source Type: research
Exploring the correlation of glycolysis-related chondroitin polymerizing factor ( < em > CHPF < /em > ) with clinical characteristics, immune infiltration, and cuproptosis in bladder cancer
Am J Cancer Res. 2023 Jun 15;13(6):2213-2233. eCollection 2023.ABSTRACTBladder cancer (BLCA) is a common malignant neoplasm of the urinary system. Glycolysis is an essential metabolic pathway regulated by various genes with implications for tumor progression and immune escape. Scoring the glycolysis for each sample in the TCGA-BLCA dataset was done using the ssGSEA algorithm for quantification. The results showed that the score in BLCA tissues was markedly greater than those in adjacent tissues. Additionally, the score was found to be correlated with metastasis and high pathological stage. Functional enrichment analyses of...
Source: Cell Research - July 10, 2023 Category: Cytology Authors: Quliang Zhong Kehua Jiang Facai Zhang Yuan Tian Jiang Gu Tao Li Xulong Chen Jianjun Yang Fa Sun Source Type: research
NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway.PMID:37392963 | DOI:10.1016/j.yexcr.2023.113693
Source: Cell Research - July 1, 2023 Category: Cytology Authors: Ze Wu Qiongqiong Jia Boqun Liu Lanlan Fang Peter C K Leung Jung-Chien Cheng Source Type: research
Cancers, Vol. 15, Pages 3461: PRMT-1 and p120-Catenin as EMT Mediators in Osimertinib Resistance in NSCLC
In this study, we investigated the role of PRMT-1 and p120-catenin in mediating Osimertinib resistance (OR) through EMT. These studies found upregulation of gene and protein expression of PRMT-1, p120-catenin and Kaiso factor. Knockdown of p120-catenin using siRNA increased OR efficacy by 45% as compared to cells treated with mock siRNA and OR. After 24 h of transfection, the percentage wound closure in cells transfected with p120-catenin siRNA was 26.2%. However, in mock siRNA-treated cells the wound closure was 7.4%, showing its involvement in EMT. We also found high levels of p120-catenin expressed in 30% of smokers as ...
Source: Cancers - July 1, 2023 Category: Cancer & Oncology Authors: Kavya Sri Racherla Katrina Dovalovsky Meet Patel Emma Harper Jacob Barnard SM Nasifuzzaman Mason Smith Riya Sikand Eva Drinka Neelu Puri Tags: Article Source Type: research
