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Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
CONCLUSIONS: HSYA is expected to become an important health drug to prevent the occurrence and development of T2DM/AS.PMID:37410531 | DOI:10.1080/13880209.2023.2225543
Source: Atherosclerosis - July 6, 2023 Category: Cardiology Authors: Jianjie Rong Chuanyong Li Qiang Zhang Guangfeng Zheng Weijian Fan Zhichang Pan Shuming Shi Source Type: research

Naringenin ameliorates vascular senescence and atherosclerosis involving SIRT1 activation
CONCLUSIONS: Naringenin could ameliorate vascular senescence and atherosclerosis and the activation of SIRT1, with subsequent deacetylation and regulation of FOXO3a and PGC1α, is involved in this process.PMID:37343148 | DOI:10.1093/jpp/rgad053
Source: Atherosclerosis - June 21, 2023 Category: Cardiology Authors: Jie Wang Ruoman Wu Yiqiao Hua Shijia Ling Xiaole Xu Source Type: research

Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway
Exp Cell Res. 2023 Mar 7:113542. doi: 10.1016/j.yexcr.2023.113542. Online ahead of print.ABSTRACTEndothelial cell senescence is involved in endothelial dysfunction and aging-related vascular diseases. The D1-like dopamine receptor (DR1), a number of G-protein-coupled receptors, is currently under consideration as a potential therapeutic target for the prevention of atherosclerosis. However, the role of DR1 in regulating ox-LDL-stimulated endothelial cell senescence remains unknown. Here, we found that the elevated Prx hyperoxidation and reactive oxygen species (ROS) levels in ox-LDL-treated Human umbilical vein endothelial...
Source: Atherosclerosis - March 9, 2023 Category: Cardiology Authors: Yiming Zhao Yuxia Li Hongxia Li Sa Shi Source Type: research

Trichostatin D as a Novel KLF2 Activator Attenuates TNF α-Induced Endothelial Inflammation
Int J Mol Sci. 2022 Nov 3;23(21):13477. doi: 10.3390/ijms232113477.ABSTRACTKrüppel-like factor 2 (KLF2) is an atherosclerotic protective transcription factor that maintains endothelial cell homeostasis through its anti-inflammatory, anti-oxidant, and antithrombotic properties. The aim of this study was to discover KLF2 activators from microbial secondary metabolites and explore their potential molecular mechanisms. By using a high-throughput screening model based on a KLF2 promoter luciferase reporter assay, column chromatography, electrospray ionization mass spectrometry (ESI-MS), and nuclear magnetic resonance (NMR) spe...
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Lijuan Lei Minghua Chen Chenyin Wang Xinhai Jiang Yinghong Li Weizhi Wang Shunwang Li Liping Zhao Ren Sheng Jiangxue Han Yuyan Zhang Yuchuan Chen Biying Yan Yexiang Wu Liyan Yu Shuyi Si Yanni Xu Source Type: research

Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects
This study aimed to determine the effectiveness of Isoflavones from semen sojae preparatum (ISSP) in inhibiting oxidative stress and its important molecular mechanisms through in vivo and in vitro experiments. ApoE-/- mice were used to establish atherosclerosis models through a high-fat diet, and endothelial cells were used to establish oxidative stress injury models through ox-LDL induction. The degree of oxidative stress damage was assessed by detecting changes in ET-1, LDH, SOD, and MDA indicators. It was observed that after ISSP treatment, the oxidative stress damage of mice and endothelial cells was improved. The Nrf2...
Source: Atherosclerosis - April 18, 2022 Category: Cardiology Authors: Jinzhou Guo Jingxin Ma Kun Cai Haining Chen Ke Xie Binren Xu Desen Quan Jingyan Du Source Type: research

Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells
CONCLUSIONS: Together, our data indicate that Nrf2 insufficiency is linked to attenuation of atherosclerosis, and could diminish the pathological process by blunting LOX-1-mediated proliferation and migration of VSMCs.PMID:35299056 | DOI:10.1016/j.atherosclerosis.2022.02.025
Source: Atherosclerosis - March 17, 2022 Category: Cardiology Authors: Hongliang Li Wenwen Zhuang Tianqing Xiong Won Sun Park Song Zhang Yiwen Zha Jiali Yao Fangfang Wang Yongqi Yang Yingrui Chen Linqian Cai Ling Ling Duonan Yu Jingyan Liang Source Type: research

Inhibition of semaphorin-3a alleviates lipopolysaccharide-induced vascular injury
This study aims to investigate the effects of inhibition of Sema3A on lipopolysaccharide (LPS)-induced vascular injury in mice. The mice were randomized into three groups: control, LPS, and LPS + siRNA. Mice in the combined group were given siRNA through fast tail vein injection, then LPS was injected intraperitoneally 7 days later, finally the mice were euthanized 24 h later. Vascular function and structure were assessed by vascular injury biomarkers and relevant stainings. LPS-induced vascular dysfunction and pathological injury were substantially improved by inhibition of Sema3A. Western blot and quantitative real-time ...
Source: Atherosclerosis - February 21, 2022 Category: Cardiology Authors: Yang Fu Jian-Wei Liu Ji Wu Zu-Xiang Wu Juan Li Hui-Fang Ji Ning-Peng Liang Hong-Jin Zhang Ze-Qun Lai Yi-Fei Dong Source Type: research

NRF2 in Cardiovascular Diseases: a Ray of Hope!
AbstractHeart failure is a worldwide pandemic influencing 26 million individuals worldwide and is expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function of the cells, which leads to contractile dysfunction, myocardial hypertrophy, and fibrosis in chronic heart failure. Various targets and agents acting on these such as siRNA, miRNA, interleukin-1, opioids, vasodilators, and SGLT2 inhibitors are being evaluated for heart failure, and nuclear factor erythroid 2 –related factor 2 (NRF2) is one of them. NRF2 is a master transcription factor which is expressed in most of the tissues and exh...
Source: Journal of Cardiovascular Translational Research - November 25, 2020 Category: Cardiology Source Type: research

Xanthoangelol Prevents Ox-LDL–Induced Endothelial Cell Injury by Activating Nrf2/ARE Signaling
Conclusions: These data suggest that XAG cytoprotects against Ox-LDL–induced cell injury through activating Nrf2/ARE–mediated antioxidative stress. Cumulatively, these findings show that EX has the potential to prevent and treat AS.
Source: Journal of Cardiovascular Pharmacology - August 1, 2019 Category: Cardiology Tags: Original Article Source Type: research

Abstract P216: Nicotinamide Nucleotide Transhydrogenase Regulates Mitochondrial Redox Balance and Endothelial Function in Response to Angiotensin II Session Title: Onsite Poster Competition I With Reception
Hypertension (HTN) involves increased peripheral resistance to blood flow mediated by changes in vascular tone. Endothelial dysfunction is an initiating step in HTN and mitochondrial reactive oxygen species (ROS) contribute to endothelial dysfunction. Nicotinamide nucleotide transhydrogenase (NNT) is a critical enzyme in the regulation of mitochondrial NADPH levels and can impact mitochondrial redox status. We have demonstrated that the loss of NNT in C57Bl/6J mice is associated with a more severe hypertensive phenotype in response to Ang II characterized by mitochondrial and vascular dysfunction driven by vascular ROS pro...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Matthew Vetkoetter, Shashanka Rao K N, Xinggui Shen, Sibile Pardue, David M Krzywanski Tags: Poster Abstract Presentations Source Type: research