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Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis
In conclusion, irisin could ameliorate inflammatory microenvironment in SAE by suppressing hippocampus ferroptosis via the Nrf2/GPX4 signaling pathway.PMID:35660523 | DOI:10.1016/j.freeradbiomed.2022.05.023
Source: Free Radical Biology and Medicine - June 6, 2022 Category: Biology Authors: Jin Wang Qian Zhu Yun Wang Jun Peng Liang Shao Xinyi Li Source Type: research

Mblk ‐1 regulates sugar responsiveness in honey bee (Apis mellifera) foragers
This article is protected by copyright. All rights reserved
Source: Insect Science - September 28, 2021 Category: Biology Authors: Fang Liu, Lixian Wu, Yuan Zhang, Qiang Li, Liangbin Li, Zachary Y. Huang, Hongxia Zhao Tags: ORIGINAL ARTICLE Source Type: research

Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats
Publication date: Available online 30 August 2019Source: Life SciencesAuthor(s): Jing Zhong, Chenyue Guo, Wenting Hou, Na Shen, Changhong MiaoAbstractAimsTo investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associated encephalopathy (SAE) rats.Main methodsThe rats were randomly divided into four groups: 1) control group (subjected to sham surgery), 2) control plus Mfhas...
Source: Life Sciences - September 1, 2019 Category: Biology Source Type: research

Characterizing Protein Interactions Employing a Genome-Wide siRNA Cellular Phenotyping Screen
by Apichat Suratanee, Martin H. Schaefer, Matthew J. Betts, Zita Soons, Heiko Mannsperger, Nathalie Harder, Marcus Oswald, Markus Gipp, Ellen Ramminger, Guillermo Marcus, Reinhard Männer, Karl Rohr, Erich W.er, Robert B. Russell, Miguel A. Andrade-Navarro, Roland Eils, Rainer König Characterizing the activating and inhibiting effect of protein-protein interactions (PPI) is fundamental to gain insight into the complex signaling system of a human cell. A plethora of methods has been suggested to infer PPI from data on a large scale, but none of them is able to characterize the effect of this interaction. Here, we present ...
Source: PLoS Computational Biology - September 25, 2014 Category: Biology Authors: Apichat Suratanee et al. Source Type: research