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The clock gene, period, influences migratory flight and reproduction of the oriental armyworm, Mythimna separata
This article is protected by copyright. All rights reserved
Source: Insect Science - October 29, 2022 Category: Biology Authors: Jiayue Ji, Yueqiu Liu, Lei Zhang, Yunxia Cheng, David Stanley, Xingfu Jiang Tags: ORIGINAL ARTICLE Source Type: research

New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway
In this study, we show that triptolide activated the cGAS-STING signaling pathway in kidney tubular cells in vivo and in vitro. Renal injury models were established in BALB/c mice and human tubular epithelial cells using TPL. We found that TPL enhanced the phosphorylation levels of STING, TBK1 and IRF3, and upregulated the expression of IFNβ, which is the production of cGAS-STING signaling pathway. STING inhibitor C176 had protective effects in TPL-induced nephrocyte damage. STING siRNA down regulated the expression level of IFNβ. In addition, triptolide induced an increase in protein levels of the transcription factor B...
Source: Free Radical Biology and Medicine - June 13, 2022 Category: Biology Authors: Jun Lu Yi Zhang Huiyue Dong Jingjing Sun Ling Zhu Pengyang Liu Fuli Wen Rong Lin Source Type: research

Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease
Free Radic Biol Med. 2021 Jun 23:S0891-5849(21)00385-3. doi: 10.1016/j.freeradbiomed.2021.06.020. Online ahead of print.ABSTRACTVascular calcification is very commonly observed in patients with chronic kidney disease (CKD), but there is no efficient therapy available. Oxidative stress plays critical roles in the progression of vascular calcification. Celastrol (Cel), a natural constituent derived from Chinese herbals, exhibits anti-oxidative stress activity. Here, we investigated the effect of celastrol on vascular calcification using vascular smooth muscle cells (VSMCs), arterial rings and CKD rats. Alizarin red staining ...
Source: Free Radical Biology and Medicine - June 26, 2021 Category: Biology Authors: Xiulin Yang An Chen Qingchun Liang Qianqian Dong Mingwei Fu Xiaoyu Liu Siyi Wang Yining Li Yuanzhi Ye Zirong Lan Jing-Song Ou Lihe Lu Jianyun Yan Source Type: research

Molecular cloning of Y-Box binding protein-1 from mandarin fish and its roles in stress-response and antiviral immunity
Publication date: October 2019Source: Fish & Shellfish Immunology, Volume 93Author(s): Jian He, Tao-Lin Xie, Xiao Li, Yang Yu, Zhi-Peng Zhan, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo HeAbstractMandarin fish (Siniperca chuatsi) is a universally farmed fish species in China and has a large farming scale and economic value. With the high-density cultural mode in mandarin fish, viral diseases, such as infectious spleen and kidney necrosis virus (ISKNV) and Siniperca chuatsi rhabdovirus (SCRV), have increased loss, which has seriously restricted the development of aquaculture. Y-Box binding protein 1 (YB-1) is a member of cold s...
Source: Fish and Shellfish Immunology - August 3, 2019 Category: Biology Source Type: research

MiR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting host GS
This study provided information for understanding the molecular mechanism of SHVV pathogenicity and a potential antiviral strategy against SHVV infection.
Source: Fish and Shellfish Immunology - October 9, 2018 Category: Biology Source Type: research