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A novel synthetic peptide SVHRSP attenuates dopaminergic neurodegeneration by inhibiting NADPH oxidase-mediated neuroinflammation in experimental models of Parkinson's disease
This study was conducted to explore the protective effects of SVHRSP, a synthetic heat-resistant peptide derived from scorpion venom, against dopaminergic neurodegeneration in experimental models of PD. Results showed that SVHRSP dose-dependently reduced the loss of dopaminergic neuron in the nigrostriatal pathway and motor impairments in both rotenone and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced mouse PD models. Microglial activation and imbalance of M1/M2 polarization were also abrogated by SVHRSP in both models. In rotenone-treated primary midbrain neuron-glial cultures, loss of dopaminer...
Source: Free Radical Biology and Medicine - June 27, 2022 Category: Biology Authors: Xiaomeng Zhang Dezhen Tu Sheng Li Na Li Donglai Li Yun Gao Lu Tian Jianing Liu Xuan Zhang Jau-Shyong Hong Liyan Hou Jie Zhao Qingshan Wang Source Type: research

Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara
Publication date: September 2018Source: Redox Biology, Volume 18Author(s): Joohee Lee, Kwangho Song, Eugene Huh, Myung Sook Oh, Yeong Shik KimAbstractOxidative stress plays a key role in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Therefore, the nuclear factor-E2-related factor 2 (Nrf2), a key regulator of the antioxidative response, is considered to be important as a therapeutic target for neurodegenerative diseases. We investigated the underlying mechanism of Nrf2-mediated neuroprotective effects against oxidative stress in the PC12 cell line by 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbut...
Source: Redox Biology - July 11, 2018 Category: Biology Source Type: research

Parkin Deficiency Exacerbate Ethanol-Induced Dopaminergic Neurodegeneration by P38 Pathway dependent inhibition of autophagy and mitochondrial function
Publication date: Available online 8 December 2016 Source:Redox Biology Author(s): Chul Ju Hwang, Young Eun Kim, Dong Ju Son, Mi Hee Park, Dong-Young Choi, Pil-Hoon Park, Sang-Bae Han, Ki-Wan Oh, Jin Tae Hong Parkinson's disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra. Parkin (which encoded by Park2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive early onset familial PD. We tested the effect of Park2 on ethanol-induced dopaminergic neurodegeneration in Park2 knockout (KO) t...
Source: Redox Biology - December 7, 2016 Category: Biology Source Type: research

Protective effect of the thioredoxin and glutaredoxin systems in dopamine induced cell death.
In conclusion, our results suggest that the two redox systems are important for neuronal survival in dopamine induced cell death. PMID: 24863694 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 23, 2014 Category: Biology Authors: Arodin L, Miranda-Vizuete A, Swoboda P, Fernandes AP Tags: Free Radic Biol Med Source Type: research

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.
Abstract Microglia are the resident immune cells in the brain. Microglial activation is characteristic of several inflammatory and neurodegenerative diseases including Alzheimer's disease, multiple sclerosis, and Parkinson's disease. Though LPS-induced microglial activation in models of Parkinson's disease (PD) is well documented, the free radical-mediated protein radical formation and its underlying mechanism during LPS-induced microglial activation is not known. Here we have used immuno-spin trapping and RNA interference to investigate the role of inducible nitric oxide synthase (iNOS) in peroxynitrite-mediated ...
Source: Free Radical Biology and Medicine - April 15, 2014 Category: Biology Authors: Kumar A, Chen SH, Kadiiska MB, Hong JS, Zielonka J, Kalyanaraman B, Mason RP Tags: Free Radic Biol Med Source Type: research

Α-synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of PD.
Abstract Parkinson's disease (PD) is a multi-factorial disease resulting in preferential death of the dopaminergic neurons in the substantia nigra. Studies of PD-linked genes and toxin-induced models of PD have implicated mitochondrial dysfunction, oxidative stress and the misfolding and aggregation of α-synuclein (α-syn) as key factors in disease initiation and progression. Many of these features of PD may be modelled in cells or animal models using the neurotoxin 1-methyl-4-phenylpyridinium (MPP+). Reducing oxidative stress and NOS activity have been shown to be protective in cell or animal models of MPP+ toxi...
Source: Free Radical Biology and Medicine - October 19, 2013 Category: Biology Authors: Ryan BJ, Lourenço-Venda L, Crabtree MJ, Hale AB, Channon KM, Wade-Martins R Tags: Free Radic Biol Med Source Type: research