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miRNA-21 Inhibition suppresses the human epithelial ovarian cancer by targeting PTEN signal pathway
ConclusionThe suppression of microRNA-21 inhibits the progression of EOC profoundly. In EOC, miR-21 is negatively correlated with the expression of PTEN gene.
Source: Saudi Journal of Biological Sciences - August 10, 2019 Category: Biology Source Type: research

Induction of let-7e gene expression attenuates oncogenic phenotype in HCT-116 colorectal cancer cells through targeting of DCLK1 regulation
Publication date: Available online 8 May 2019Source: Life SciencesAuthor(s): Alisa Khodadadi Kohlan, Massoud Saidijam, Razieh Amini, Pouria Samadi, Rezvan NajafiAbstractAimsMicroRNAs (miRNAs) are small noncoding RNAs that negatively control gene expression at the translational level. There are compelling evidences indicating that the expression of let-7e is downregulated in various cancers, however, the role of let-7e in colorectal cancer (CRC) and its mechanism has been remained unknown. Here, we investigated the potential role of let-7e in regulating CRC cells phenotypes.Main methodsLet-7e and DCLK1 siRNA were transfecte...
Source: Life Sciences - May 8, 2019 Category: Biology Source Type: research

CRIP1 promotes cell migration, invasion and epithelial-mesenchymal transition of cervical cancer by activating the Wnt/β‑catenin signaling pathway
In conclusion, CRIP1 promotes cell migration and invasion, mediates EMT and activates the Wnt/β‑catenin signaling pathway in CC.
Source: Life Sciences - July 11, 2018 Category: Biology Source Type: research

CRIP1 promotes cell migration, invasion and epithelial-mesenchymal transition of cervical cancer by activating the Wnt/ β‑catenin signaling pathway
In conclusion, CRIP1 promotes cell migration and invasion, mediates EMT and activates the Wnt/β‑catenin signaling pathway in CC.
Source: Life Sciences - July 4, 2018 Category: Biology Source Type: research

In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer
Publication date: Available online 6 February 2018 Source:Life Sciences Author(s): Minwei He, Kangqi Li, Chuanfei Yu, Bingfeng Lv, Ning Zhao, Jinhai Deng, Lulu Cao, He Huang, Ang Yin, Taiping Shi, Lu Wang FUZ is regarded as a planar cell polarity effector that controls multiple cellular processes during vertebrate development. However, the role of FUZ in tumor biology remains poorly studied. Our purpose of this study is to discover the physiological effects and mechanism of FUZ in non-small-cell lung cancer (NSCLC) in vitro. With the help of bioinformatics analysis, we noticed that the expression level of FUZ negatively c...
Source: Life Sciences - February 7, 2018 Category: Biology Source Type: research

Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells
Conclusions: Our results provide the first evidence that a natural anti-cancer compound mediates its cellular and in vivo tumor anti-proliferative responses by selectively stimulating cellular interactions of the stem/progenitor cell marker nucleostemin with MDM2, which frees p53 to trigger its apoptotic response. Furthermore, our study provides a new mechanistic template that can be potentially exploited for the development of cancer stem/progenitor cell targeted therapeutic strategies.
Source: BMC Biology - Latest articles - September 12, 2014 Category: Biology Authors: Antony TinAnna ParkShyam SundarGary Firestone Source Type: research

AKT/mTOR and C-Jun N-terminal Kinase (JNK) Signaling Pathways Are Required for Chrysotile Asbestos-Induced Autophagy.
Abstract Chrysotile asbestos is closely associated with excess mortality from pulmonary diseases such as lung cancer, mesothelioma, and asbestosis. Although multiple mechanisms in which chrysotile asbestos fibers induce pulmonary disease have been identified, the role of autophagy in human lung epithelial cells has not been examined. In the present study, we evaluated whether chrysotile asbestos induces autophagy in A549 human lung epithelial cells, and then analyzed the possible underlying molecular mechanism. Chrysotile asbestos-induced autophagy in A549 cells based on a series of biochemical and microscopic aut...
Source: Free Radical Biology and Medicine - April 12, 2014 Category: Biology Authors: Lin Z, Liu T, Kamp DW, Wang Y, He H, Zhou X, Li D, Yang L, Zhao B, Liu G Tags: Free Radic Biol Med Source Type: research

Loss of p53 in stromal fibroblasts promotes epithelial cell invasion through redox-mediated ICAM1 Signal.
Abstract Tumor microenvironment plays a major role in cancer development. Understanding how the stroma affects epithelial transformation will provide a basis for new preventive strategies. Recent evidences suggest that oxidative stress in stroma may play a role in cancer progression and loss of p53 function in the stromal cells were associated with poor prognosis and high tumor recurrence. However, the underlying mechanisms remain poorly understood. Here, we investigated the role of p53 loss in fibroblasts on epithelial transformation and the mechanistic involvement of reactive species. Using 3D-organotypic cultur...
Source: Free Radical Biology and Medicine - January 29, 2013 Category: Biology Authors: Trachootham D, Chen G, Zhang W, Lu W, Zhang H, Liu J, Huang P Tags: Free Radic Biol Med Source Type: research