Filtered By:
Specialty: Biology
Cancer: Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 92 results found since Jan 2013.
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Free Radic Biol Med. 2023 Sep 13:S0891-5849(23)00627-5. doi: 10.1016/j.freeradbiomed.2023.09.009. Online ahead of print.ABSTRACTTranscription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the principal determinant of the cellular redox homeostasis, contributing to mitochondrial function, integrity and bioenergetics. The main negative regulator of Nrf2 is Kelch-like ECH associated protein 1 (Keap1), a substrate adaptor for Cul3/Rbx1 ubiquitin ligase, which continuously targets Nrf2 for ubiquitination and proteasomal degradation. Loss-of-function mutations in Keap1 occur frequently in lung cancer, leading ...
Source: Free Radical Biology and Medicine - September 15, 2023 Category: Biology Authors: Sharadha Dayalan Naidu Plamena R Angelova Elena V Knatko Chiara Leonardi Miroslav Novak Laureano de la Vega Ian G Ganley Andrey Y Abramov Albena T Dinkova-Kostova Source Type: research
Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer
Free Radic Biol Med. 2021 Oct 19;177:58-71. doi: 10.1016/j.freeradbiomed.2021.10.020. Online ahead of print.ABSTRACTActivating mutations in the KEAP1/NRF2 pathway characterize a subset of non-small cell lung cancer (NSCLC) associated with chemoresistance and poor prognosis. We herein evaluated the relationship between 64 oxidative stress-related genes and overall survival data from 35 lung cancer datasets. Thioredoxin reductase-1 (TXNRD1) stood out as the most significant predictor of poor outcome. In a cohort of NSCLC patients, high TXNRD1 protein levels correlated with shorter disease-free survival and distal metastasis-...
Source: Free Radical Biology and Medicine - October 21, 2021 Category: Biology Authors: Marina Delgobo Ros ângela Mayer Gonçalves Marco Ant ônio Delazeri Marcelo Falchetti Alessandro Zandon á Raquel Nascimento das Neves Karoline Almeida Adriane Cristina Fagundes Daniel Pens Gelain Jo ão Isidro Fracasso Guilherme Baroni de Mac êdo Leona Source Type: research
hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin
Publication date: 15 July 2021Source: Life Sciences, Volume 277Author(s): Somayyeh Ghareghomi, Shahin Ahmadian, Nosratollah Zarghami, Salar Hemmati
Source: Life Sciences - May 17, 2021 Category: Biology Source Type: research
Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy
Publication date: Available online 28 March 2021Source: Life SciencesAuthor(s): Sepideh Mirzaei, Mohammad Hossein Gholami, Farid Hashemi, Amirhossein Zabolian, Kiavash Hushmandi, Vahid Rahmanian, Maliheh Entezari, Yarabahally R. Girish, Kothanahally S. Sharath Kumar, Amir Reza Aref, Pooyan Makvandi, Milad Ashrafizadeh, Ali Zarrabi, Haroon Khan
Source: Life Sciences - March 29, 2021 Category: Biology Source Type: research
Advances in siRNA delivery strategies for the treatment of MDR cancer
Publication date: Available online 11 March 2021Source: Life SciencesAuthor(s): Md Abdus Subhan, Sara Aly Attia, Vladimir P. Torchilin
Source: Life Sciences - March 11, 2021 Category: Biology Source Type: research
Co-delivery of EGFR and BRD4 siRNA by cell-penetrating peptides-modified redox-responsive complex in triple negative breast cancer cells
Publication date: Available online 10 December 2020Source: Life SciencesAuthor(s): Chi Zhang, Wen Yuan, Ying Wu, Xu Wan, Yanling Gong
Source: Life Sciences - December 13, 2020 Category: Biology Source Type: research
Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice
Publication date: Available online 9 December 2020Source: Life SciencesAuthor(s): Shima Bastaki, Surendar Aravindhan, Nasrin Ahmadpour Saheb, Mahsa Afsari Kashani, Aleksi Evgenievich Dorofeev, Fariba Karoon Kiani, Hediyeh Jahandideh, Farzaneh Beigi Dargani, Mohsen Aksoun, Afshin Nikkhoo, Ali Masjedi, Ata Mahmoodpoor, Majid Ahmadi, Sanam Dolati, Simin Namvar, Farhad Jadidi-Niaragh
Source: Life Sciences - December 10, 2020 Category: Biology Source Type: research
Decreasing Arl4c expression by inhibition of AKT signal in human lung adenocarcinoma cells
ConclusionHere, we highlighted the AKT pathway as an important regulatory pathway for Arl4c expression in lung cancer cells and identified HCPT as a promising drug for lung adenocarcinoma treatment that functioned by targeting Arl4c expression.
Source: Life Sciences - February 13, 2020 Category: Biology Source Type: research
Small interfering RNA targeting alpha7 nicotinic acetylcholine receptor sensitizes hepatocellular carcinoma cells to sorafenib
Publication date: Available online 18 January 2020Source: Life SciencesAuthor(s): Khalil Hajiasgharzadeh, Mohammad Hossein Somi, Behzad Mansoori, Vahid Khaze Shahgoli, Afshin Derakhshani, Ahad Mokhtarzadeh, Dariush Shanehbandi, Behzad BaradaranAbstractAimsIt has been demonstrated that reduced expression of alpha7 nicotinic acetylcholine receptor (α7nAChR) led to reduced chemotherapeutic drugs resistance in various cancer cells. However, whether small interfering RNA (siRNA) mediated knockdown of α7nAChR can reduce sorafenib (SOR) resistance in HCC cells remains to be determined.Materials and methodsThe effects of α7nACh...
Source: Life Sciences - January 18, 2020 Category: Biology Source Type: research
Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer
We examined the role of dihydrolipoamide dehydrogenase (DLD) in ferroptosis induction in head and neck cancer (HNC). The effects of cystine deprivation or sulfasalazine treatment and of DLD gene silencing/overexpression were tested on HNC cell lines and mouse tumor xenograft models. These effects were analyzed with regard to cell death, lipid reactive oxygen species (ROS) and mitochondrial iron production, mitochondrial membrane potential, mRNA/protein expression, and α-ketoglutarate dehydrogenase (KGDH)/succinate/aconitase activities. Cystine deprivation induced ferroptosis via glutaminolysis. Cystine deprivation or impo...
Source: Redox Biology - January 8, 2020 Category: Biology Source Type: research
The Inhibition of the Histone Methyltransferase EZH2 by DZNEP or SiRNA Demonstrates Its Involvement in MGMT, TRA2A, RPS6KA2, and U2AF1 Gene Regulation in Prostate Cancer
OMICS: A Journal of Integrative Biology, Ahead of Print.
Source: OMICS: A Journal of Integrative Biology - December 30, 2019 Category: Biology Authors: Driss El Ouardi Mouhamed Idrissou Anna Sanchez Fr édérique Penault-Llorca Yves-Jean Bignon Laurent Guy Dominique Bernard-Gallon Source Type: research
BCLAF1 promotes cell proliferation, invasion and drug-resistance though targeting lncRNA NEAT1 in hepatocellular carcinoma
Publication date: Available online 20 December 2019Source: Life SciencesAuthor(s): Shao-Jiao Mou, Peng-Fei Yang, Yi-Pin Liu, Ning Xu, Wei-Wei Jiang, Wen-Jing YueAbstractAimsIn the present research, we aimed to investigate the effect of Bcl-2-associated transcription factor 1 (BCLAF1) on hepatocellular carcinoma and further explore the special molecular mechanism.Main methodsThe expression of BCLAF1 was analyzed in tumor tissues and different hepatocellular cancer cell lines by real-time RT-PCR and Western blot. Cell proliferation and invasion was explored using MTT and Transwell assay respectively. In addition, luciferase ...
Source: Life Sciences - December 20, 2019 Category: Biology Source Type: research
TEX19 promotes ovarian carcinoma progression and is a potential target for epitope vaccine immunotherapy
This study aimed to reveal the role of TEX19 in ovarian cancer (OC) and searched for potential candidate epitope peptides of TEX19 to facilitate clinical application.Main methodsTEX19 levels were evaluated by immunohistochemistry (IHC) in 98 human ovarian tissue samples. The correlation of TEX19 levels with patients' clinicopathological features was assessed. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting analysis were utilized to detect TEX19 levels in ovarian cell lines and TEX19-deficient cells. The level of TEX19 in OVCAR-3 and A2780 was knocked down by small interfering RNA (siRNA), an...
Source: Life Sciences - December 14, 2019 Category: Biology Source Type: research
NALP3 orchestrates cellular bioenergetics to facilitate non-small cell lung cancer cell growth
This study was to unravel the mechanism of NALP3 on modulating NSCLC cancer cell growth.MethodsIHC and immuno-blot were performed to analyze expression of NALP3 and indicated molecules. CCK-8 and xenograft nude mice assay were used to evaluate cell growth in vitro and in vivo. Bioenergetics assay was performed to measure OXPHOS and aerobic glycolysis. siRNA and shRNA were constructed to knockdown endogenous NALP3 and DNMT1. Co-immunoprecipitation was applied to confirm the interaction between NALP3 and DMAP1. BioProfile FLEX analyzer and Lactate Reagent Kit were used to measure relative level glucose uptake and lactate pro...
Source: Life Sciences - December 14, 2019 Category: Biology Source Type: research
