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Specialty: Chemistry
Therapy: Cancer Therapy

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Total 33 results found since Jan 2013.

Metal-Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications
Chem Rec. 2023 Mar 13:e202300018. doi: 10.1002/tcr.202300018. Online ahead of print.ABSTRACTMetal-organic frameworks (MOFs), a distinctive funtionalmaterials which is constructed by various metal ions and organic molecules, have gradually attracted researchers' attention from they were founded. In the last decade, MOFs emerge as a biomedical material with potential applications due to their unique properties. However, the MOFs performed as nanocarriers for functional nucleic acid delivery in biomedical applications rarely summarized. In this review, we introduce recent developments of MOFs for nucleic acid delivery in vari...
Source: Chemical Record - March 13, 2023 Category: Chemistry Authors: Li He Mengdi Shang Zhongkai Chen Zhaoqi Yang Source Type: research

Molecules, Vol. 28, Pages 917: Site-Specific Antibody Conjugation with Payloads beyond Cytotoxins
u As antibody–drug conjugates have become a very important modality for cancer therapy, many site-specific conjugation approaches have been developed for generating homogenous molecules. The selective antibody coupling is achieved through antibody engineering by introducing specific amino acid or unnatural amino acid residues, peptides, and glycans. In addition to the use of synthetic cytotoxins, these novel methods have been applied for the conjugation of other payloads, including non-cytotoxic compounds, proteins/peptides, glycans, lipids, and nucleic acids. The non-cytotoxic compounds include polyethyl...
Source: Molecules - January 17, 2023 Category: Chemistry Authors: Qun Zhou Tags: Review Source Type: research

Advances in Engineered Biomaterials Targeting Angiogenesis and Cell Proliferation for Cancer Therapy
We present advances in engineering of liposome/hydrogel/micelle-based biomaterials for delivery of combination of anticancer and anti-angiogenesis drugs, or combination of anticancer and siRNA targeting angiogenesis, and targeted nanoparticles. We then present our perspective on developing strategies for targeting angiogenesis and cell proliferation for cancer therapy.PMID:36103616 | DOI:10.1002/tcr.202200152
Source: Chemical Record - September 14, 2022 Category: Chemistry Authors: Poonam Yadav Chhavi Dua Avinash Bajaj Source Type: research

Molecules, Vol. 27, Pages 1302: Selenocystine-Derived Label-Free Fluorescent Schiff Base Nanocomplex for siRNA Delivery Synergistically Kills Cancer Cells
In this study, we developed a nanocarrier for siRNA based on a selenocystine analog engineered polyetherimide and achieved traceable siRNA delivery and the synergic killing of tumor cells. Notably, we applied the label-free Schiff base fluorescence mechanism, which enabled us to trace the siRNA delivery and to monitor the selenocystine analogs’ local performance. A novel selenocystine-derived fluorescent Schiff base linker was used to crosslink the polyetherimide, thereby generating a traceable siRNA delivery vehicle with green fluorescence. Moreover, we found that this compound induced tumor cells to undergo...
Source: Molecules - February 15, 2022 Category: Chemistry Authors: Yang Liu Haoying Yang Qian Liu Mingming Pan Danli Wang Shiyuan Pan Weiran Zhang Jinfeng Wei Xiaowei Zhao Junfeng Ji Tags: Article Source Type: research

Oligonucleotides carrying nucleoside antimetabolites as potential prodrugs
CONCLUSION: It is expected that oligonucleotides carrying nucleoside antimetabolites will be considered as potential drugs in the near future for biomedical applications.PMID:34844535 | DOI:10.2174/0929867328666211129124039
Source: Current Medicinal Chemistry - November 30, 2021 Category: Chemistry Authors: Carme F àbrega Anna Clua Ramon Eritja Anna Avi ñó Source Type: research

ASAP Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy
ACS Combinatorial ScienceDOI: 10.1021/acscombsci.0c00099
Source: ACS Combinatorial Science - October 23, 2020 Category: Chemistry Authors: Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Farid Hashemi, Ebrahim Rahmani Moghadam, Mehdi Raei, Mahshad Kalantari, Shima Tavakol □, Reza Mohammadinejad■, Masoud Najafi, Franklin R. Tay△, and Pooyan Makvandi▽ Source Type: research

A tubular DNA nanodevice as a siRNA/chemo-drug co-delivery vehicle for combined  cancer therapy.
A tubular DNA nanodevice as a siRNA/chemo-drug co-delivery vehicle for combined cancer therapy. Angew Chem Int Ed Engl. 2020 Oct 21;: Authors: Wang Z, Song L, Liu Q, Tian R, Shang Y, Liu F, Liu S, Zhao S, Han Z, Sun J, Jiang Q, Ding B Abstract Using the DNA origami technique, we constructed a DNA nanodevice functionalized with small interference RNA (siRNA) within its inner cavity and the chemotherapeutic drug doxorubicin (DOX), intercalated in the DNA duplexes. The incorporation of disulfide bonds allows the triggered mechanical opening and release of siRNA in response to intracellular glutathione (...
Source: Angewandte Chemie - October 21, 2020 Category: Chemistry Authors: Wang Z, Song L, Liu Q, Tian R, Shang Y, Liu F, Liu S, Zhao S, Han Z, Sun J, Jiang Q, Ding B Tags: Angew Chem Int Ed Engl Source Type: research

Molecules, Vol. 25, Pages 2692: Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy
les RNA interference (RNAi) uses small interfering RNAs (siRNAs) to mediate gene-silencing in cells and represents an emerging strategy for cancer therapy. Successful RNAi-mediated gene silencing requires overcoming multiple physiological barriers to achieve efficient delivery of siRNAs into cells in vivo, including into tumor and/or host cells in the tumor micro-environment (TME). Consequently, lipid and polymer-based nanoparticle siRNA delivery systems have been developed to surmount these physiological barriers. In this article, we review the strategies that have been developed to facilitate siRNA survival in the ci...
Source: Molecules - June 9, 2020 Category: Chemistry Authors: Francesco Mainini Michael R. Eccles Tags: Review Source Type: research

Preparation of poly(glutamic acid) shielding micelles self-assembled from polylysine-b-polyphenylalanine for gene and drug codelivery
Publication date: Available online 19 February 2020Source: Chinese Chemical LettersAuthor(s): Jing Ma, Jingpeng Zhang, Lin Chi, Chong Liu, Yanhui Li, Huayu TianABSTRACTA novel amphiphilic cationic block copolymer polylysine-b-polyphenylalanine (PLL-b-PPhe) was synthesized and self-assembled into micelles in aqueous solution, then shielded with poly(glutamic acid) (marked as PG/PLL-b-PPhe) to codeliver gene and drug for combination cancer therapy. Here, doxorubicin (DOX) was selected to be loaded into PLL-b-PPhe micelles and the drug loading efficiency was 8.0%. The drug release studies revealed that the PLL-b-PPhe micelles...
Source: Chinese Chemical Letters - February 19, 2020 Category: Chemistry Source Type: research

Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase C{delta}-4 (PLC{delta}4) Cell Biology
Calcium (Ca2+) signaling within the cell nucleus regulates specific cellular events such as gene transcription and cell proliferation. Nuclear and cytosolic Ca2+ levels can be independently regulated, and nuclear translocation of receptor tyrosine kinases (RTKs) is one way to locally activate signaling cascades within the nucleus. Nuclear RTKs, including the epidermal growth factor receptor (EGFR), are important for processes such as transcriptional regulation, DNA-damage repair, and cancer therapy resistance. RTKs can hydrolyze phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) within the nucleus, leading to Ca2+ release f...
Source: Journal of Biological Chemistry - November 7, 2019 Category: Chemistry Authors: Marcelo Coutinho de Miranda, Michele Angela Rodrigues, Ana Carolina de Angelis Campos, Jerusa Arauȷo Quintao Arantes Faria, Marianna Kunrath–Lima, Gregory A. Mignery, Deborah Schechtman, Alfredo Miranda Goes, Michael H. Nathanson, Dawidson A. Tags: Signal Transduction Source Type: research

Co-delivery of paclitaxel and survivin siRNA with cationic liposome for lung cancer therapy
Publication date: Available online 3 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Chuanmin Zhang, Shubiao Zhang, Defu Zhi, Yinan Zhao, Shaohui Cui, Jingnan CuiAbstractThis work designed a new delivery system (L-PTX-PSur), which could efficiently co-deliver paclitaxel (PTX) and survivin siRNA (Sur) to overcome the dose-limiting toxicity by effectively accumulating PTX in tumor and obtain enhanced therapy by synergistic effect. In this co-delivery system, protamine was selected to condense siRNA into a compacted ‘core’, and a carbamate-linked cationic lipid was used to de...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - October 4, 2019 Category: Chemistry Source Type: research