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Pyrrolidinedione-thiazolidinone hybrid molecules with potent cytotoxic effect in squamous cell carcinoma SCC-15 cells
This study aimed to investigate the cytotoxic effect of three derivatives 1-(4-hydroxyphenyl)-, 1-(4-chlorophenyl)- and 1-(4-bromophenyl)-3-[5-[2-chloro-3-(4-nitrophenyl)prop-2-enylidene]-4-oxo-2-thioxothiazolidine-3-yl]pyrrolidine-2,5-diones (Les-6287, Les-6294, and Les-6328, respectively), their effect on the production of the reactive oxygen species (ROS), apoptosis induction, and expression of genes - PPARγ, AHR, and NRFL2 - whose products are important in metabolism in human tongue squamous cell carcinoma cells of SCC-15 line. The results of resazurin reduction and lactate dehydrogenase (LDH) release assays proved th...
Source: Bioorganic and Medicinal Chemistry - August 14, 2023 Category: Chemistry Authors: Nataliya Finiuk Edyta Kaleniuk Serhii Holota Rostyslav Stoika Roman Lesyk Konrad A Szychowski Source Type: research

Molecules, Vol. 28, Pages 2191: Potential of siRNA-Bearing Subtilosomes in the Treatment of Diethylnitrosamine-Induced Hepatocellular Carcinoma
grawal Mohammad Owais Therapeutics, based on small interfering RNA (siRNA), have demonstrated tremendous potential for treating cancer. However, issues such as non-specific targeting, premature degradation, and the intrinsic toxicity of the siRNA, have to be solved before they are ready for use in translational medicines. To address these challenges, nanotechnology-based tools might help to shield siRNA and ensure its specific delivery to the target site. Besides playing a crucial role in prostaglandin synthesis, the cyclo-oxygenase-2 (COX-2) enzyme has been reported to mediate carcinogenesis in various types of canc...
Source: Molecules - February 27, 2023 Category: Chemistry Authors: Fauzia Jamal Ghufran Ahmed Mohammad Farazuddin Ishrat Altaf Saba Farheen Qamar Zia Asim Azhar Hira Ahmad Aijaz Ahmed Khan Satyanarayana Somavarapu Anshu Agrawal Mohammad Owais Tags: Article Source Type: research

Molecules, Vol. 27, Pages 8457: CD70-Targeted Micelles Enhance HIF2 & alpha; siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells
Molecules, Vol. 27, Pages 8457: CD70-Targeted Micelles Enhance HIF2α siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells Molecules doi: 10.3390/molecules27238457 Authors: Noah Trac Hyun Seok Oh Leila Izzy Jones Randy Caliliw Shinji Ohtake Brian Shuch Eun Ji Chung The majority of clear cell renal cell carcinomas (ccRCCs) are characterized by mutations in the Von Hippel–Lindau (VHL) tumor suppressor gene, which leads to the stabilization and accumulation of the HIF2α transcription factor that upregulates key oncogenic pat...
Source: Molecules - December 2, 2022 Category: Chemistry Authors: Noah Trac Hyun Seok Oh Leila Izzy Jones Randy Caliliw Shinji Ohtake Brian Shuch Eun Ji Chung Tags: Article Source Type: research

Nebulization of siRNA for inhalation therapy based on a microfluidic surface acoustic wave platform
Ultrason Sonochem. 2022 Jun 30;88:106088. doi: 10.1016/j.ultsonch.2022.106088. Online ahead of print.ABSTRACTThe local delivery of therapeutic small interfering RNA or siRNA to the lungs has the potential to improve the prognosis for patients suffering debilitating lung diseases. Recent advances in materials science have been aimed at addressing delivery challenges including biodistribution, bioavailability and cell internalization, but an equally important challenge to overcome is the development of an inhalation device that can deliver the siRNA effectively to the lung, without degrading the therapeutic itself. Here, we ...
Source: Ultrasonics Sonochemistry - July 7, 2022 Category: Chemistry Authors: Christina Cortez-Jugo Sarah Masoumi Peggy P Y Chan James Friend Leslie Yeo Source Type: research

Effects of long noncoding RNA AK093407 on the biological behavior of colon cancer cells and the underlying mechanism
CONCLUSION: These results showed that knockdown of AK093407 could inhibit colon cancer cell proliferation, induce apoptosis and cell cycle arrest, influence the expression of vital factors in mitochondrial apoptosis pathway and cell cycle regulatory pathway, and may negatively regulate JAK/STAT3 through down-regulating p-Stat3.PMID:35400339 | DOI:10.2174/1386207325666220408092028
Source: Combinatorial Chemistry and High Throughput Screening - April 11, 2022 Category: Chemistry Authors: Zhao Xuerong Sun Ao Wang Jianping Zheng Xin Tian Duoduo Wang Mingjuan Xiao Lijun Zhao Enhong Zheng-Guo Cui Source Type: research

Molecules, Vol. 27, Pages 2082: Inhibition of Metastatic Hepatocarcinoma by Combined Chemotherapy with Silencing VEGF/VEGFR2 Genes through a GalNAc-Modified Integrated Therapeutic System
Jing Hu Hepatocellular carcinoma (HCC) is a highly malignant tumor related to high mortality and is still lacking a satisfactory cure. Tumor metastasis is currently a major challenge of cancer treatment, which is highly related to angiogenesis. The vascular endothelial growth factor (VEGF)/VEGFR signaling pathway is thus becoming an attractive therapeutic target. Moreover, chemotherapy combined with gene therapy shows great synergistic potential in cancer treatment with the promise of nanomaterials. In this work, a formulation containing 5-FU and siRNA against the VEGF/VEGFR signaling pathway into N-acetyl-galactosam...
Source: Molecules - March 24, 2022 Category: Chemistry Authors: Xunan Li Xiang Wang Nian Liu Qiuyu Wang Jing Hu Tags: Article Source Type: research

PCSK9 as a new player in cancer: New opportunity or red herring?
Curr Med Chem. 2021 Nov 15. doi: 10.2174/0929867328666211115122324. Online ahead of print.ABSTRACTInitially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Besides that, a number of studies have suggested PCSK9 may play a role in cancer biology. This is particularly true for gastroenteric (gastric and liver cancers) and lung cancers, where higher PCSK9 levels were associated with the increased ability of the tumor to develop and give metastasis as well as with...
Source: Current Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Aldo Bonaventura Alessandra Vecchi é Massimiliano Ruscica Francesco Grossi Francesco Dentali Source Type: research

Heat-induced manganese-doped magnetic nanocarriers combined with Yap-siRNA for MRI/NIR-guided mild photothermal and gene therapy of hepatocellular carcinoma
Publication date: 15 December 2021Source: Chemical Engineering Journal, Volume 426Author(s): Qian Zhang, Weiyong Zhao, Jin Cheng, Zhoufeng Deng, Ping Zhang, Amin Zhang, Zhi Xu, Shaojun Pan, Xinmei Liao, Daxiang Cui
Source: Chemical Engineering Journal - June 20, 2021 Category: Chemistry Source Type: research

Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function Signal Transduction
IQGAP1 is a key scaffold protein that regulates numerous cellular processes and signaling pathways. Analogous to many other cellular proteins, IQGAP1 undergoes post-translational modifications, including phosphorylation. Nevertheless, very little is known about the specific sites of phosphorylation or the effects on IQGAP1 function. Here, using several approaches, including MS, site-directed mutagenesis, siRNA-mediated gene silencing, and chemical inhibitors, we identified the specific tyrosine residues that are phosphorylated on IQGAP1 and evaluated the effect on function. Tyr-172, Tyr-654, Tyr-855, and Tyr-1510 were phos...
Source: Journal of Biological Chemistry - December 25, 2020 Category: Chemistry Authors: Andrew C. Hedman, Dean E. McNulty, Zhigang Li, Laetitia Gorisse, Roland S. Annan, David B. Sacks Tags: Signal Transduction Source Type: research

Histone deacetylase 1 regulates the malignancy of oral cancer cells via miR-154-5p/PCNA axis.
Authors: Lv Y, Lu J, Liu X, Miao S, Li B, Pei R, Xiang C Abstract Histone deacetylases (HDACs) can regulate the progression of various cancers, while their roles in oral cancer cells are not well known. Our present study found that the HDAC1 was over expressed in oral squamous cell carcinoma (OSCC) cells and tissues. Targeted inhibition of HDAC1 via its specific inhibitor PCI24781 or siRNA can inhibit the proliferation of OSCC cells and increase their sensitivity to the chemo-sensitivity such as doxorubicin (Dox) treatment. HDAC1 can regulate the expression of proliferating cell nuclear antigen (PCNA) via decreasin...
Source: Biological Chemistry - June 20, 2020 Category: Chemistry Tags: Biol Chem Source Type: research

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