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Specialty: Environmental Health
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Total 205 results found since Jan 2013.
Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver
Ecotoxicol Environ Saf. 2023 Aug 15;263:115374. doi: 10.1016/j.ecoenv.2023.115374. Online ahead of print.ABSTRACTAs a new type of persistent organic pollutant, perfluorooctane sulphonate (PFOS) has received extensive attention worldwide. Cannabidiol (CBD) is a non-psychoactive natural cannabinoid extract that has been proved to have antioxidation, regulation of inflammation and other functions. However, the effects of PFOS on liver injury and whether CBD can alleviate PFOS-induced liver injury are still unclear. Therefore, in this study, we used CBD (10 mg/kg) and/or PFOS (5 mg/kg) to intraperitoneally inject mice for 30 d...
Source: Ecotoxicology and Environmental Safety - August 17, 2023 Category: Environmental Health Authors: Dongliu Luo Jintao Zhang Hang Yin Shanshan Li Shiwen Xu Shu Li Source Type: research
Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish
Ecotoxicol Environ Saf. 2023 Jul 11;263:115241. doi: 10.1016/j.ecoenv.2023.115241. Online ahead of print.ABSTRACTCadmium (Cd) exposure is a risk factor for endothelial dysfunction and cardiovascular disease. Ferroptosis is a type of cell death that relies on lipid peroxidation. Whether ferroptosis acts in Cd-induced vascular endothelial damage and the underlying mechanisms remain unclear. Herein, we found that Cd resulted in ferroptosis of vascular endothelial cells (ECs) in vivo and in vitro. In the visualized zebrafish embryos, Cd accumulated in vascular ECs, ROS and lipid peroxidation levels were increased, and the oxid...
Source: Ecotoxicology and Environmental Safety - July 13, 2023 Category: Environmental Health Authors: Tian Zhang Wenhua Yan Cong Liu Weixia Duan Yu Duan Yuanyuan Li Qin Yu Yapei Sun Jiacheng Tian Jie Zhou Zhiqin Xia Guixue Wang Shangcheng Xu Source Type: research
Lnc001209 Participates in aluminium-induced apoptosis of PC12 cells by regulating PI3K-AKT-mTOR signalling pathway
This study aimed to investigate the mechanisms and signalling pathways involved in aluminium exposure-induced neuronal apoptosis. The results showed a decrease in the number of PC12 cells and changes in cell morphology in the aluminium maltol exposure group. The viability of PC12 cells decreased gradually with increasing of exposure doses, and the apoptosis rate increased. The expression of Lnc001209 decreased gradually with an increase in the aluminium exposure dose. After transfection of Lnc001209 siRNA in aluminium-exposed PC12 cells, the protein expression levels of p-Akt Ser473, p-Akt Thr308, p-P85 Tyr467, p-mTOR Ser2...
Source: Ecotoxicology and Environmental Safety - May 25, 2023 Category: Environmental Health Authors: Huan Li Qinli Zhang Xingli Xue Jingsi Zhang Shanshan Wang Jing Zhang Li Lin Qiao Niu Source Type: research
Hexavalent chromium Cr(VI)-induced ribosomal DNA copy number variation and DNA damage responses and their associations with nucleolar protein HRAS in humans and cells
Environ Pollut. 2023 May 12:121816. doi: 10.1016/j.envpol.2023.121816. Online ahead of print.ABSTRACTThe carcinogenicity of hexavalent chromium [Cr(VI)] and its compounds has been widely recognized, yet the mechanism of genetic damage is still not fully understood. The ribosomal DNA (rDNA) copy number is recently considered a potential marker of cancer-associated stress. To investigate the roles of rDNA copy number variation (CNV) in DNA damage responses (DDRs) induced by Cr(VI) and the potential mechanism from nucleolar protein HRAS, a cross-sectional study in Cr(Ⅵ)-exposed workers and an in vitro experiment using HeLa ...
Source: Environmental Pollution - May 14, 2023 Category: Environmental Health Authors: Huadong Xu Li Shi Lingfang Feng Fan Wu Junfei Chen Yao Qin Xiaowen Dong Zhaoqiang Jiang Yongxin Li Hailing Xia Jianlin Lou Source Type: research
Lead exposure disturbs ATP7B-mediated copper export from brain barrier cells by inhibiting XIAP-regulated COMMD1 protein degradation
In conclusion, Pb exposure can reduce XIAP protein expression, increase COMMD1 protein levels, and specifically decrease ATP7B protein levels, resulting in Cu accumulation in brain barrier cells.PMID:37027943 | DOI:10.1016/j.ecoenv.2023.114861
Source: Ecotoxicology and Environmental Safety - April 7, 2023 Category: Environmental Health Authors: Yang Liu Zai-Hua Zhao Tao Wang Jin-Yu Yao Wen-Qing Wei Li-Hong Su Shuang-Shuang Tan Zi-Xuan Liu Han Song Jing-Yuan Chen Wei Zheng Wen-Jing Luo Gang Zheng Source Type: research
Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice
Ecotoxicol Environ Saf. 2023 Mar 16;255:114799. doi: 10.1016/j.ecoenv.2023.114799. Online ahead of print.ABSTRACTIncreasing evidence have demonstrated that early-life exposure to environmental toxicants elevates risk of allergic asthma. Cadmium (Cd) is widely present in the environment. The purposes of this study were to evaluate the impact of early-life Cd exposure on susceptibility to ovalbumin (OVA)-evoked allergic asthma. Newly weaned mice were subjected to a low concentration of CdCl2 (1 mg/L) by drinking water for 5 consecutive weeks. Penh value, an index of airway obstruction, was increased in OVA-stimulated and cha...
Source: Ecotoxicology and Environmental Safety - March 18, 2023 Category: Environmental Health Authors: Wen-Jing Wang Xue Lu Zhao Li Kun Peng Ping Zhan Lin Fu Yan Wang Hui Zhao Hua Wang De-Xiang Xu Zhu-Xia Tan Source Type: research
Role of SESTRIN2/AMPK/ULK1 pathway activation and lysosomes dysfunction in NaAsO < sub > 2 < /sub > -induced liver injury under oxidative stress
Ecotoxicol Environ Saf. 2023 Mar 10;254:114751. doi: 10.1016/j.ecoenv.2023.114751. Online ahead of print.ABSTRACTArsenic, a serious environmental poison to human health, is widely distributed in nature. As the main organ of arsenic metabolism, liver is easily damaged. In the present study, we found that arsenic exposure can cause liver injury in vivo and in vitro, to date the underlying mechanism of which is yet unclear. Autophagy is a process that depends on lysosomes to degrade damaged proteins and organelles. Here, we reported that oxidative stress can be induced and then activated the SESTRIN2/AMPK/ULK1 pathway, damage...
Source: Ecotoxicology and Environmental Safety - March 12, 2023 Category: Environmental Health Authors: Dingnian Bi Dan Zheng Mingyang Shi Qian Hu Hongling Wang Haiyan Zhi Didong Lou Aihua Zhang Yong Hu Source Type: research
Therapeutic potential of amitriptyline for paraquat-induced pulmonary fibrosis: Involvement of caveolin-1-mediated anti-epithelial-mesenchymal transition and inhibition of apoptosis
CONCLUSION: AMT inhibited PQ-induced EMT in A549 cells and improved lung histopathology and oxygenation in mice by up-regulating caveolin-1.PMID:36898313 | DOI:10.1016/j.ecoenv.2023.114732
Source: Ecotoxicology and Environmental Safety - March 10, 2023 Category: Environmental Health Authors: Jianshi Chen Xiangdong Jian Chunmei Li Bihuang Cheng Source Type: research
Nrf2/PINK1-mediated mitophagy induction alleviates sodium fluoride-induced hepatic injury by improving mitochondrial function, oxidative stress, and inflammation
Ecotoxicol Environ Saf. 2023 Feb 13;252:114646. doi: 10.1016/j.ecoenv.2023.114646. Online ahead of print.ABSTRACTMitophagy has distinct functions, which can lead to either protection or damage of tissues. Though current evidence indicated that NaF triggers mitophagy, the role and regulation of mitophagy in sodium fluoride (NaF)-induced liver injury still remain unclear. Therefore, we exployed the cell and mouse models and confirmed that NaF treatment activates mitophagy. Knocking down PTEN-induced putative kinase protein 1 (PINK1) expression attenuated mitophagy and increased the degree of mitochondrial impairment, oxidati...
Source: Ecotoxicology and Environmental Safety - February 15, 2023 Category: Environmental Health Authors: Chao Song Aiguo Zhang Man Zhang Yuzhen Song Heping Huangfu Shuangxing Jin Yanting Sun Chunhui Zhang Dongmei Shi Jundong Wang Wei Peng Qin Luo Source Type: research
