Lead exposure disturbs ATP7B-mediated copper export from brain barrier cells by inhibiting XIAP-regulated COMMD1 protein degradation

In conclusion, Pb exposure can reduce XIAP protein expression, increase COMMD1 protein levels, and specifically decrease ATP7B protein levels, resulting in Cu accumulation in brain barrier cells.PMID:37027943 | DOI:10.1016/j.ecoenv.2023.114861

Source: Ecotoxicology and Environmental Safety - April 7, 2023 Category: Environmental Health Authors: Yang Liu Zai-Hua Zhao Tao Wang Jin-Yu Yao Wen-Qing Wei Li-Hong Su Shuang-Shuang Tan Zi-Xuan Liu Han Song Jing-Yuan Chen Wei Zheng Wen-Jing Luo Gang Zheng Source Type: research