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Vitamin D Receptor/Vitamin D Response Element Directly Modulate < b > < i > Nestin < /i > < /b > Transcription to Ameliorate PAN-Induced Podocyte Morphological Changes
Conclusions: Paricalcitol directly regulates nestin transcription through the interaction of VDR/VDRE, thereby preventing morphological changes of podocytes in PAN nephropathy.Nephron
Source: Nephron - May 6, 2022 Category: Urology & Nephrology Source Type: research

Vitamin D/vitamin D receptor/Atg16L1  axis maintains podocyte autophagy and survival in diabetic kidney disease
CONCLUSION: Autophagy protects podocytes from damage in DN and is modulated by VitD3/VDR signaling and downstream regulation of Atg16L1 expression.PMID:35469547 | DOI:10.1080/0886022X.2022.2063744
Source: Renal Failure - April 26, 2022 Category: Urology & Nephrology Authors: Lang Shi Chao Xiao Yafei Zhang Yao Xia Hongchu Zha Jiefu Zhu Zhixia Song Source Type: research

Vitamin D protects glomerular mesangial cells from high glucose-induced injury by repressing JAK/STAT signaling
ConclusionVitamin D (VD) treatment inhibits the function of HG on fibronectin production through regulating JAK/STAT pathway. These results provide direct evidences that VD protects glomerular mesangial cells from high glucose-induced injury through repressing JAK/STAT signaling, which has the potential for clinical DN treatment.
Source: International Urology and Nephrology - May 3, 2021 Category: Urology & Nephrology Source Type: research