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Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells
CONCLUSION: These results demonstrate that inhibition of TRPC6/NFAT2 signaling attenuates GMC dysfunction and the development of DKD and suggest that pharmacological targeting of TRPC6/NFAT2 in GMCs may provide beneficial effects for DKD.PMID:36285371 | DOI:10.1080/0886022X.2022.2134796
Source: Renal Failure - October 26, 2022 Category: Urology & Nephrology Authors: Jian Yu Chunchun Li Lisha Ma Bin Zhai Aiping Xu Decui Shao Source Type: research

Effect of Forkhead Box O1 in Renal Tubular Epithelial Cells on Endotoxin-Induced Acute Kidney Injury.
In conclusion, downregulation of FOXO1 in RTECs mediated endotoxin-induced AKI and mitochondrial damage. Overexpression of FOXO1 could improve renal injury and mitochondrial dysfunction, and this effect occurred at least in part as a result of PGC1-α signaling. FOXO1 might be a potential target for the prevention and treatment of endotoxin-induced AKI. PMID: 33356954 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - December 28, 2020 Category: Urology & Nephrology Authors: Zhang M, Dong W, Li Z, Xiao Z, Xie Z, Ye Z, Liu S, Li R, Chen Y, Zhang L, Wang M, Liang H, Baihetiyaer R, Apaer R, Dong Z, Liang X Tags: Am J Physiol Renal Physiol Source Type: research

{beta}-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis
In this study we investigated the role of β-arrestins in regulating extracellular matrix (ECM) synthesis in renal fibrosis. The rat kidney fibroblast cell line (NRK-49F) was treated with the β-arrestin biased agonist [1-sar, 4, 8-ile]angiotensin II (SII), which does not initiate AT1R-G protein signaling. The cells were transfected with recombinant adenoviruses expressing β-arrestin-2 gene or small-interfering RNA (siRNA) targeting β-arrestin-2. The unilateral ureteral obstruction (UUO) model was used in vivo. mRNA and protein levels of β-arrestin-2, not β-arrestin-1, were significantly upregul...
Source: AJP: Renal Physiology - July 1, 2017 Category: Urology & Nephrology Authors: Wang, Y., Huang, J., Liu, X., Niu, Y., Zhao, L., Yu, Y., Zhou, L., Lu, L., Yu, C. Tags: RESEARCH ARTICLE Source Type: research

SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression
In this study, we explored the expression patterns of CXCL2 and CCL2 in kidney tissue from Sirt2–/– and Sirt2+/+ mice and in mouse proximal tubular epithelial (MPT) cells. CXCL2 and CCL2 were significantly downregulated at both the mRNA and the protein levels in kidneys of LPS-treated Sirt2–/– mice compared with those of LPS-treated Sirt2+/+ mice. Furthermore, SIRT2 deficiency ameliorated LPS-induced infiltration of neutrophils and macrophages, acute tubular injury, and decrease of renal function. Supporting these observations, CXCL2 and CCL2 expression levels were lower in MPT cells treated with SI...
Source: Journal of the American Society of Nephrology : JASN - June 30, 2015 Category: Urology & Nephrology Authors: Jung, Y. J., Lee, A. S., Nguyen-Thanh, T., Kim, D., Kang, K. P., Lee, S., Park, S. K., Kim, W. Tags: Basic Research Source Type: research

Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease
Conclusion• Specific inhibition of HDAC2 with RNA interference may represent a novel targeted therapy for PD.
Source: BJU International - May 19, 2014 Category: Urology & Nephrology Authors: Ki‐Dong Kwon, Min Ji Choi, Jin‐Mi Park, Kang‐Moon Song, Mi‐Hye Kwon, Dulguun Batbold, Guo Nan Yin, Woo Jean Kim, Ji‐Kan Ryu, Jun‐Kyu Suh Tags: Translational Science Source Type: research