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Tumor protein p53-induced nuclear protein 2 modulates osteogenic differentiation of human adipose derived stem/stromal cells by activating Wnt/ β-catenin signaling.
Tumor protein p53-induced nuclear protein 2 modulates osteogenic differentiation of human adipose derived stem/stromal cells by activating Wnt/β-catenin signaling. Am J Transl Res. 2020;12(10):6853-6867 Authors: Dong S, Li J, Zhang X Abstract Human adipose derived stem/stromal cells (hASCs) are frequently used as seed cells in bone tissue engineering. These cells have good osteogenic properties in various in vivo and in vitro models. Tumor protein p53-induced nuclear protein 2 (TP53INP2) regulates apoptosis, autophagy, and cell differentiation. However, whether TP53INP2 regulates osteogenic differenti...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Aggravation of Cerebral Ischemia/Reperfusion Injury by Peroxisome Proliferator-Activated Receptor-Gamma Deficiency via Endoplasmic Reticulum Stress.
CONCLUSIONS This research proved that PPAR-γ protected the brain from cerebral I/R injury by repressing ER stress and indicated that PPAR-γ is a potential target in the treatment of ischemia. PMID: 31588926 [PubMed - in process]
Source: Medical Science Monitor - October 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Role of B-Cell Lymphoma 2 Ovarian Killer (BOK) in Acute Toxicity of Human Lung Epithelial Cells Caused by Cadmium Chloride.
CONCLUSIONS These findings support a role for BOK in CdCl₂-induced DNA damage and cell death. PMID: 31323016 [PubMed - in process]
Source: Medical Science Monitor - July 21, 2019 Category: Research Tags: Med Sci Monit Source Type: research

p38 MAPK is Crucial for Wnt1- and LiCl-Induced Epithelial Mesenchymal Transition
SummaryIdiopathic pulmonary fibrosis (IPF) is characterized by myofibroblast foci in lung parenchyma. Myofibroblasts are thought to originate from epithelial-to-mesenchymal transition (EMT). Wnt1 and lithium chloride (LiCl) induce EMT in alveolar epithelial cells (AECs), but the mechanisms are unclear. AECs were treated with Wnt1 and LiCl, respectively; morphological change and molecular changes of EMT, including E-cadherin, fibronectin, and vimentin, were observed. SB203580 was administrated to test the role of p38 МАРК signaling in EMT. Then AECs were treated with siRNAs targeting p38 МАРК to further test the eff...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - June 1, 2018 Category: Research Source Type: research