• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Glucocorticoid Enhanced the Expression of Ski in Osteonecrosis of Femoral Head: The Effect on Adipogenesis of Rabbit BMSCs
AbstractGlucocorticoid (GC)-induced osteonecrosis has been considered as the most serious side effect in long-term or over-dose steroid therapy. The decreased bone mass and increased marrow fat tissue demonstrated that GC can destroy the normal differentiation of bone marrow mesenchymal stem cells (BMSCs), which accelerates adipogenesis but not osteogenesis. However, the underlying mechanisms are still unclear. Ski, an evolutionary conserved protein, is a multifunctional transcriptional regulator that involved in regulating signaling pathways associated with adipogenesis differentiation, but the concrete function remains u...
Source: Calcified Tissue International - July 29, 2019 Category: Orthopaedics Source Type: research

Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice
In conclusion, our data suggest that paracrine PAI-1 is involved in GC-induced muscle wasting through the enhancement of muscle degradation in mice.
Source: Journal of Bone and Mineral Metabolism - March 19, 2017 Category: Orthopaedics Source Type: research

TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt Pathway in Steroid ‐Associated Osteonecrosis
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - August 31, 2016 Category: Orthopaedics Authors: Jie Zhao, Xin ‐long Ma, Jian‐xiong Ma, Lei Sun, Bin Lu, Ying Wang, Guo‐sheng Xing, Yan Wang, Ben‐chao Dong, Li‐yan Xu, Ming‐Jie Kuang, Lin Fu, Hao‐hao Bai, Yue Ma, Wei‐lin Jin Tags: Original Article Source Type: research