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Delta-like Factor 1 as a Possible Therapeutic Target for Sarcomas.
Conclusions: Our study showed that the DLK1 gene induces tumorigenesis in various sarcomas and is associated with invasive mechanism in sarcoma. These results suggest DLK1 could serve as a possible therapeutic target in a variety of sarcomas. PMID: 32904069 [PubMed - in process]
Source: Clinics in Orthopedic Surgery - September 11, 2020 Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research

Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway
In this study, we aimed to explore the functions of Ras-related protein Rab-31 (RAB31) in OS-cell proliferation, migration, and invasion as well as its roles in the Hedgehog signaling pathway for better understanding of the mechanism. To assess the detailed regulatory mechanism of RAB31 silencing on OS, both RT-qPCR and Western blot analysis were employed to evaluate the expressions of RAB31 as well as the Hedgehog signaling pathway-related genes. Besides, we also investigated the effects of silenced RAB31 both in vitro and in vivo. First, we found that in OS tissues, both mRNA and protein expressions of RAB31 and PCNA had...
Source: Journal of Bone and Mineral Metabolism - November 23, 2018 Category: Orthopaedics Source Type: research

Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone
This study suggests FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents.
Source: Calcified Tissue International - January 17, 2017 Category: Orthopaedics Source Type: research

Small Players Ruling the Hard Game: siRNA in Bone Regeneration
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - February 1, 2016 Category: Orthopaedics Authors: S Ghadakzadeh, M Mekhail, A Aoude, R Hamdy, M Tabrizian Tags: Review Source Type: research

MicroRNA Regulates Vascular Endothelial Growth Factor Expression in Chondrosarcoma Cells.
CONCLUSIONS: miR-181a is a hypoxia-regulated microRNA that is overexpressed in chondrosarcoma and enhances VEGF expression, an effect that could be inhibited by anti-miR-181a. CLINICAL RELEVANCE: Systemic treatment options for chondrosarcoma are limited. Antiangiogenic strategies could potentially be effective in limiting tumor progression. One method of inhibiting VEGF expression and associated angiogenesis could be an antagomir-based therapy targeted at miR-181a or other oncogenic microRNAs, although methods of systemic delivery are still under development. The effectiveness of antagomirs also needs to be compared w...
Source: Clinical Orthopaedics and Related Research - August 9, 2014 Category: Orthopaedics Authors: Sun X, Wei L, Chen Q, Terek RM Tags: Clin Orthop Relat Res Source Type: research

Proteomic Identification of 14‐3‐3ϵ as a Linker Protein Between pERK1/2 Inhibition and BIM Upregulation in Human Osteosarcoma Cells
We examined the expression of Bim after silencing 14‐3‐3ϵ using siRNA. The 14‐3‐3ϵ gene silencing resulted in downregulation of Bim expression after PD98059 treatment. These data indicate that 14‐3‐3ϵ is required for Bim expression and that it has an anti‐cancer effect under pERK1/2 inhibition in 143B cells. By playing an essential role upstream of Bim, 14‐3‐3ϵ may potentially be a coadjuvant factor synergizing the effect of pERK1/2 inhibitors in addition to conventional cytotoxic agents for more effective osteosarcoma treatments. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Source: Journal of Orthopaedic Research - February 17, 2014 Category: Orthopaedics Authors: Kyung Ok Kim, Anny C. Hsu, Heon Goo Lee, Neel Patel, Chandhanarat Chandhanayingyong, Thomas Hickernell, Francis Young‐In Lee Tags: Research Article Source Type: research