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Kojic acid inhibits senescence of human corneal endothelial cells via NF- κB and p21 signaling pathways.
In this study, we investigated the anti-senescence effect of kojic acid on HCEC. Cell viability, migration ability and senescence were evaluated by MTT assay, migration assay, and senescence-associated beta-galactosidase (SA-β-Gal) staining, respectively. Senescence-related protein expression was analyzed by western blotting and immunofluorescence assay. Angiogenesis of human umbilical vein endothelial cells (HUVEC) was examined by tube formation assay and spheroid sprouting assay. The results showed that kojic acid could inhibit HCEC senescence, characterized by enhancing migration, decreasing the levels of SA-β-Gal sta...
Source: Experimental Eye Research - December 28, 2018 Category: Opthalmology Authors: Wei X, Luo D, Yan Y, Yu H, Sun L, Wang C, Song F, Ge H, Qian H, Li X, Tang X, Liu P Tags: Exp Eye Res Source Type: research

CD25 siRNA induces Treg/Th1 cytokine expression in rat corneal transplantation models.
In conclusion, CD25 siRNA gene therapy played a protective role in corneal graft rejection via up-regulation of Treg cytokine expression and down-regulation of Th1 cytokine expression. PMID: 27567557 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - August 23, 2016 Category: Opthalmology Authors: Qin Q, Luo D, Shi Y, Zhao Q, Chen Y, Wu J, Zhao M Tags: Exp Eye Res Source Type: research

Current treatments for corneal neovascularization.
Authors: Benayoun Y, Petellat F, Leclerc O, Dost L, Dallaudière B, Reddy C, Robert PY, Salomon JL Abstract The extension of blood vessels into the normally avascular stroma defines corneal neovascularization. Though this phenomenon, pathophysiological and clinical features are well characterized, therapeutic modalities have been hindered by a lack of safe, efficacious and non-controversial treatments. In this literature review, we focus on available therapeutic options in light of recent evidence provided by animal and clinical studies. First, this review will focus on pharmacological treatments that target angiog...
Source: Journal Francais d Ophtalmologie - November 28, 2015 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

Role of Angiopoietin-2 in Corneal Lymphangiogenesis Cornea
Conclusions. Angiopoietin-2 is critically involved in lymphatic processes in vivo and in vitro. Further investigation of the Ang-2 pathway may provide novel insights and therapeutic strategies for lymphatic-related disorders, which occur both inside and outside the eye.
Source: Investigative Ophthalmology - May 29, 2014 Category: Opthalmology Authors: Yuen, D., Grimaldo, S., Sessa, R., Ecoiffier, T., Truong, T., Huang, E., Bernas, M., Daley, S., Witte, M., Chen, L. Tags: Cornea Source Type: research