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MicroRNA Let-7c-5p-mediated regulation of ERCC6 disrupts autophagic flux in age-related cataract via the binding to VCP
CONCLUSION: In ARC, Let-7c-5p-mediated downregulation of ERCC6 might prevent the degradation of autophagic vacuoles. CSB binds to VCP, inducing autophagosomes to combine with lysosomes and be degraded.PMID:33703976 | DOI:10.1080/02713683.2021.1900273
Source: Current Eye Research - March 11, 2021 Category: Opthalmology Authors: Yu Cao Pengfei Li Guowei Zhang Lihua Kang Tianqiu Zhou Jian Wu Yong Wang Ying Wang Xiaojuan Chen Huaijin Guan Source Type: research

LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
Conclusions: Our findings reveal that MALAT1 may regulate EMT, proliferation, and migration of LECs as a ceRNA by "sponging" miR-204-5p and targeting Smad4, and serve as a promising therapeutic target in preventing PCO. PMID: 33327804 [PubMed - as supplied by publisher]
Source: Current Eye Research - December 17, 2020 Category: Opthalmology Authors: Peng C, Wang Y, Ji L, Kuang L, Yu Z, Li H, Zhang J, Zhao J Tags: Curr Eye Res Source Type: research

Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.
Authors: Lanza M, Benincasa G, Costa D, Napoli C Abstract Network medicine is a molecular-bioinformatic approach analyzing gene-gene interactions that can perturb the human interactome. This review focuses on epigenetic changes involved in several ocular diseases, such as DNA methylation, histone and nonhistone post-translational modifications, and noncoding RNA regulators. Although changes in aberrant DNA methylation play a major role in the pathogenesis of most ocular diseases, histone modifications are seldom investigated. Hypermethylation in TGM-2 and hypomethylation in MMP-2/CD24 promoter genes may play a cruc...
Source: Journal of Ophthalmology - January 25, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Loss of Calpastatin Leads to Activation of Calpain in Human Lens Epithelial Cells Lens
Conclusions. Our data demonstrated that the high levels of endogenous CS do, indeed, inhibit calpain activity in normal human lens epithelial cells. We speculate that age-related oxidation might cause loss of CS activity in human lens epithelial cells, allowing activation of long-dormant calpain 2, proteolysis of critical cytoskeletal proteins, and cataract formation.
Source: Investigative Ophthalmology - August 22, 2014 Category: Opthalmology Authors: Nakajima, T., Shearer, T. R., Azuma, M. Tags: Lens Source Type: research