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MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis.
CONCLUSION: Altogether, up-regulated miR-204 suppresses pyroptosis of FLSs in AS via suppressing GSDMD, which may help us to understand the mechanism of AS deeply. PMID: 33359850 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - December 20, 2020 Category: Allergy & Immunology Authors: Gu G, Huo Y, Xu G, Li L, Yu J, Sheng L, Yin Z Tags: Int Immunopharmacol Source Type: research

Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1 β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor
Management of pain in the treatment of rheumatoid arthritis (RA) is a priority that is not fully addressed by the conventional therapies. In the present study, we evaluated the efficacy of cannabinoid receptor 2 (CB2) agonist JWH-015 using RA synovial fibroblasts (RASFs) obtained from patients diagnosed with RA and in a rat adjuvant-induced arthritis (AIA) model of RA. Pretreatment of human RASFs with JWH-015 (10-20 µM) markedly inhibited the ability of pro-inflammatory cytokine interleukin-1β (IL-1β) to induce production of IL-6 and IL-8 and cellular expression of inflammatory cyclooxygenase-2 (COX-2). JWH-015 was effe...
Source: Frontiers in Immunology - May 7, 2019 Category: Allergy & Immunology Source Type: research

FKN Facilitates HK-2 Cell EMT and Tubulointerstitial Lesions via the Wnt/ β-Catenin Pathway in a Murine Model of Lupus Nephritis
In this study, we therefore examined whether FKN could stimulate the process of EMT, NF-kB, TGFβ, CCL22, F4/80, inflammation, and tubulointerstitial fibrosis in a murine model of LN. We also determined whether FKN was involved in the EMT process of Wnt/β-catenin-expressing HK-2 cells. Mechanistically, we ascertained, for the first time, whether FKN up-regulated EMT-related gene signatures (e.g., vimentin, α-SMA), and hence, renal tubulointerstitial fibrogenesis, and the role of the Wnt/β-catenin signaling pathway in this process. Materials and Methods Cell Culture, Stable Infection, and Gr...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
We described a new defense mechanism based on IFIT5 antiviral activity in nucleated RBCs that appeared to contribute to halting the VHSV infection. This finding sheds light into novel antiviral therapeutics to mitigate the economic losses and social impact caused by viral infections in the aquaculture industry. This work broadens the knowledge of fish nucleated RBCs functions and their role in the immune response to viral infections. Ethics Statement Experimental protocols and methods relating to experimental animals were reviewed and approved by the Animal Welfare Body and the Research Ethics Committee at the University...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides
Conclusion: Bypass of tolerance by DAMPs might be a phenomenon as important as TI, since it could explain how chronic inflammation can be maintained in spite of an environment with multiple TLR2/TLR4-ligands. In RA monocytes, a PRDM8-dependent TI mechanism could be responsible for sustained chemokine/cytokines levels. Introduction Monocytes and macrophages play a central role in the pathophysiology of inflammation. For instance, in rheumatoid arthritis (RA), activated monocytes massively infiltrate synovial tissues and produce tumor necrosis factor-α (TNFα) (1–3). Accordingly, therapies aime...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF- κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells
This study aimed to determine the protecting effects of catalpol against homocysteine (HCY)-induced injuries in human aortic endothelial cells (HAECs) and uncover the underlying mechanisms: 1. HAECs were cultured with different concentrations of HCY (3  mM) and catalpol (7.5 μΜ, 15 μΜ, 30 μΜ) for 24 h. (1) The level of MDA and GSH as well as LDH release was measured with colorimetric assay. (2) Reactive oxygen species (ROS) were detected by flow cytometry analysis. (3) Western blotting analysis was performed to detect the expression of Nox4, p22phox, ICAM-1, MCP-1, VCAM-1, I κB, nucleus p65, p65 phosphorylation...
Source: Inflammation - October 12, 2018 Category: Allergy & Immunology Source Type: research

Hypoxia induces production of citrullinated proteins in human fibroblast ‐like synoviocytes through regulating HIF1α
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Ruohan Yu, Changhong Li, Lin Sun, Leilei Jian, Zhenzhen Ma, Jinxia Zhao, Xiangyuan Liu Tags: Regular Article Source Type: research

Inhibition of Interferon regulatory factor 4 Suppresses Th1 and Th17 Cell Differentiation and Ameliorates Experimental Autoimmune Encephalomyelitis
In conclusion, inhibition of IRF4 suppresses Th1 and Th17 cell differentiation and ameliorates EAE, via a direct regulation of DCs. This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Chunsheng Yang, Dan He, Chuang Yin, Jun Tan Tags: Regular Manuscript Source Type: research

Inhibition of Interferon Regulatory Factor 4 Attenuates Acute Liver Allograft Rejection in Mice
In conclusion, inhibition of IRF4 attenuates acute liver allograft rejection in mice, and this is associated with promoted M2 macrophage differentiation. This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - June 12, 2015 Category: Allergy & Immunology Authors: Wei Zhao, Zhong Zhang, Qingjun Zhao, Mengjie Liu, Yuelan Wang Tags: Regular Article Source Type: research

Platelet Factor 4 Limits Th17 Differentiation and Ischaemia–Reperfusion Injury After Liver Transplantation in Mice
In conclusion, PF4 limits liver IRI through IL‐17 inhibition via upregulation of SOCS3.
Source: Scandinavian Journal of Immunology - January 20, 2015 Category: Allergy & Immunology Authors: H. Guo, Y. Wang, Z. Zhao, X. Shao Tags: Experimental Immunology Source Type: research

GSK3β negatively regulates LPS‐induced osteopontin expression via inhibiting its transcription
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - January 6, 2015 Category: Allergy & Immunology Authors: Hui Song, Benqiang Deng, Chao Zou, Wanwan Huai, Rui Zhao, Wei Zhao Tags: Regular Article Source Type: research

Platelet factor 4 limits Th17 differentiation and ischemia‐reperfusion injury after liver transplantation in mice
In conclusion, PF4 limits liver IRI through IL‐17 inhibition via up‐regulation of SOCS3. This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - November 29, 2014 Category: Allergy & Immunology Authors: Hefeng Guo, Zhiming Zhao, Yue Wang Tags: Regular Manuscript Source Type: research

IL‐17 Induces Expression of Vascular Cell Adhesion Molecule Through Signalling Pathway of NF‐κB, but not Akt1 and TAK1 in Vascular Smooth Muscle Cells
In this study, we reported that IL‐17‐induced expression of VCAM‐1 in SMCs is dependent on NF‐κB, but independent of Akt1 and TAK1. This is because knocking down Akt1 or TAK1 by siRNA did not reduce IL‐17‐induced activation of NF‐κB and expression of VCAM‐1, whereas knocking down NF‐κB by siRNA markedly inhibited IL‐17‐mediated upregulation of VCAM‐1 expression. In addition, IL‐17‐induced expression of VCAM‐1 is partially dependent on activation of ERK1/2. Therefore, these signalling pathways of IL‐17‐mediated upregulation of VCAM‐1 expression might be therapeutic targets for treatmen...
Source: Scandinavian Journal of Immunology - March 26, 2013 Category: Allergy & Immunology Authors: H. Zhang, J. Chen, X. Liu, L. Awar, A. McMickle, F. Bai, S. Nagarajan, S. Yu Tags: Experimental Immunology Source Type: research

IL‐17 induces expression of vascular cell adhesion molecule through signaling pathway of NF‐κB, but not Akt1 and TAK1 in vascular smooth muscle cells
In this study, we reported that IL‐17 induced expression of VCAM‐1 in SMCs is dependent on NF‐κB, but independent of Akt1 and TAK1. This is because knocking down Akt1 or TAK1 by siRNA did not reduce IL‐17‐induced activation of NF‐κB and expression of VCAM‐1, whereas knocking down NF‐κB by siRNA markedly inhibited IL‐17‐mediated upregulation of VCAM‐1 expression. In addition, IL‐17‐induced expression of VCAM‐1 is partially dependent on activation of ERK1/2. Therefore, these signaling pathways of IL‐17‐mediated upregulation of VCAM‐1 expression might be therapeutic targets for treatment o...
Source: Scandinavian Journal of Immunology - February 19, 2013 Category: Allergy & Immunology Authors: Haitao Zhang, Jing Chen, Xiaoming Liu, Lena Awar, Anthony McMickle, Fengwu Bai, Shanmugam Nagarajan, Shiguang Yu Tags: Experimental Immunology Source Type: research

Pro‐IL‐16 is associated with MHC class II‐mediated negative regulation of mouse resting B cell activation through MAP kinases, NF‐κB, and Skp2‐dependent p27kip regulation
Abstract MHC class II molecules, in addition to their essential role as antigen‐presenting molecules to CD4+ T cell receptor, have a signal‐transducing role related to B cell function. We identified pro‐IL‐16 as one of the proteins associated with MHC class II‐mediated signaling in an analysis of MHC class II‐associated molecules using immunoprecipitation and proteomics data obtained from the 38B9 resting B‐cell line, and investigated the role of pro‐IL‐16 in resting B‐cell activation. We found that pro‐IL‐16, rather than mature form of IL‐16, is present in both in the cytoplasm and nucleus of res...
Source: Scandinavian Journal of Immunology - January 8, 2013 Category: Allergy & Immunology Authors: Hee‐Young Yang, Ju Kim, Sae‐Hae Kim, Chung‐Hyeon Choe, Yong‐Suk Jang Tags: Experimental Immunology Source Type: research