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Specialty: Allergy & Immunology
Condition: Rheumatoid Arthritis
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Total 66 results found since Jan 2013.
CD5L aggravates rheumatoid arthritis progression via promoting synovial fibroblasts proliferation and activity
In conclusion, CD5L promote RA disease progression via activating RASFs. CD5L blocking is a potential therapeutic approach for RA patients.PMID:37191481 | DOI:10.1093/cei/uxad054
Source: Clinical and Developmental Immunology - May 16, 2023 Category: Allergy & Immunology Authors: Xia-Nan Wu Zhao-Wei Gao Lan Yang Juan Zhang Chong Liu Hui-Zhong Zhang Ke Dong Source Type: research
CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity
Int Immunopharmacol. 2023 Apr 13;119:110163. doi: 10.1016/j.intimp.2023.110163. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) mediate many pathological processes in rheumatoid arthritis (RA), including pannus formation, bone erosion, and inflammation. RA FLS have unique aggressive phenotypes and exhibit several tumor cell-like characteristics, including hyperproliferation, excessive migration and invasion. Casein kinase 2 (CK2) is reportedly overexpressed in numerous tumor types, and targeted inhibition of CK2 has therapeutic benefits for tumors. However, the expression level of CK2 and its functions in ...
Source: International Immunopharmacology - April 15, 2023 Category: Allergy & Immunology Authors: Yanping Luo Yunxuan Lei Xin Guo Dehao Zhu Haiyang Zhang Zizhen Guo Zichong Xu Hanqing Zhao Yebin Xi Xiaochun Peng Lianbo Xiao Zhaojun Wang Xiaoyin Niu Guangjie Chen Source Type: research
Photoacoustic/ultrasound-guided gene silencing: Multifunctional microbubbles for treating adjuvant-induced arthritis
CONCLUSIONS: The theranostic MBs exhibited a TNF-α gene silencing effect under the guidance of CEUS and PAI. The theranostic MBs served as vehicles for delivering siRNA as well as contrast agents for CEUS and PAI.PMID:37012868 | DOI:10.1016/j.intimp.2023.109978
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Chenyang Zhao Rui Zhang Sirui Liu Xuelan Li Desheng Sun Yuxin Jiang Meng Yang Source Type: research
BAFF Promotes FLS Activation Through BAFFR-Mediated Non-canonical NF- κB Pathway and the Effects of CP-25
In this study, we aimed to understand the mechanism by which BAFF activates FLS and the effect of CP-25 on FLS function. Therefore, the proliferation and migration abilities of FLS and key proteins on the non-canonical NF- κB pathway were examined. The results showed that compared with the FLS of normal rats/OA patients, the expression of BAFF-R, TRAF2, NIK, p-IKKα, P100, and P52 was higher in the FLS of AA rats/RA patients, while the expression of TRAF3 was lower. And, BAFF promotes FLS activation by activating the non-canonical NF-κB signaling pathway. Meanwhile, BAFFR-siRNA inhibited the proliferation of FLS and the ...
Source: Inflammation - January 16, 2023 Category: Allergy & Immunology Source Type: research
Preparation of Mesoporous Silica Nanocarriers Targeting Glucose-6-Phosphate Isomerase Inhibition and Application in the Treatment of Rheumatoid Arthritis
In conclusion, siG6PI-MSN effectively suppress the proliferation and invasive growth of synovial tissue and improve joint swelling and inflammatory infiltration, thereby preventing joint damage in RA. This carrier may be a new therapeutic measure for RA, with potential social and economic benefits.PMID:36610698 | DOI:10.1093/cei/uxac116
Source: Clinical and Developmental Immunology - January 7, 2023 Category: Allergy & Immunology Authors: Ming Zong Yu Cheng Bei Ye Saige Chen Shanshan Yu Menglei Ding Liu Lu Lieying Fan Source Type: research
Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/ β-catenin/c-Myc pathway in rheumatoid arthritis
Int Immunopharmacol. 2022 Oct 21;113(Pt A):109328. doi: 10.1016/j.intimp.2022.109328. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and progressive joint destruction in the middle and late stages. Notably, activated rheumatoid arthritis synovial fibroblasts (RASFs) exhibit tumor-like features, including an increased proliferation rate that largely contributes to pannus formation and joint destruction. Our previous studies have demonstrated that acid-sensing ion channel 1a (ASIC1a) was highly expressed in RASFs, and acidic microenvironment of sy...
Source: International Immunopharmacology - October 24, 2022 Category: Allergy & Immunology Authors: Yayun Xu Zheng Lu Yian Ling Ruirui Hou Jingjing Tao Ge Deng Xiaoling Xu Xuewei Chen Jingjing Ruan Yihao Zhang Xiaoqing Peng Feihu Chen Source Type: research
