Filtered By:
Specialty: Allergy & Immunology
Cancer: Cancer

This page shows you your search results in order of date.

Order by Relevance | Date

Total 125 results found since Jan 2013.

Deciphering the immunological and prognostic features of bladder cancer through platinum-resistance-related genes analysis and identifying potential therapeutic target P4HB
ConclusionOur study demonstrates that the PRR signatures are significantly associated with clinical-pathological features, the TIME, and prognostic features. The key PRR gene, P4HB, s a biomarker for the individualized treatment of BLCA patients.
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research

Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer
This study suggests an emerging strategy based on a combination of EZH2 inhibitor and immunotherapy based on PD-1 inhibition.PMID:37708707 | DOI:10.1016/j.intimp.2023.110918
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Mengmeng Lv Sheng Guo Xinyu Zhang Yan Zou Qiang Chen Chongyi Zang Shuo Huang Yuhan Hu Yanling Wang Qianqing Wang Jiateng Zhong Source Type: research

AURKA inhibitor-induced PD-L1 upregulation impairs antitumor immune responses
DiscussionOur data demonstrated that MLN8237 improved the effect of immunology-related therapy on tumor cells by interacting with anti-PD-L1 antibody, which contributed to producing creative sparks for exploring the possible solutions to overcoming drug resistance to tumor targeted therapy.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research

Crosstalk between PD-L1 and Jak2-Stat3/ MAPK-AP1 signaling promotes oral cancer progression, invasion and therapy resistance
CONCLUSIONS: PD-L1 was regulated mainly by the Jak2-Stat3/ MAPK-AP1 pathway, and besides the routine immunological functions, it supports OSCC survival, invasion, and therapy resistance. PD-L1 can be used as an indicator of severity and can be targeted along with Jak2-Stat3/ MAPK-AP1 for a better outcome OSCC.PMID:37678027 | DOI:10.1016/j.intimp.2023.110894
Source: International Immunopharmacology - September 7, 2023 Category: Allergy & Immunology Authors: Arpita Jha Manzar Alam Tanushree Kashyap Nidhi Nath Anjali Kumari Kamdeo K Pramanik Siddavaram Nagini Rajakishore Mishra Source Type: research

Exosomal circRNA-001264 promotes AML immunosuppression through induction of M2-like macrophages and PD-L1 overexpression
Int Immunopharmacol. 2023 Aug 30;124(Pt A):110868. doi: 10.1016/j.intimp.2023.110868. Online ahead of print.ABSTRACTExosomes can help to effectively regulate the crosstalk between cancer cells and normal cells in the tumor microenvironment. They also regulate cancer cell proliferation and apoptosis by virtue of their cargo molecules. Transmission electron microscopy (TEM) together with differential ultracentrifugation served for verifying the presence of exosomes. In vivo and in vitro assays served for determining the role of exosomal circ_001264. RNA pull-down and dual-luciferase reporter assays assisted in the classifica...
Source: International Immunopharmacology - September 1, 2023 Category: Allergy & Immunology Authors: Ashuai Du Qinglong Yang Xiaoying Sun Qiangqiang Zhao Source Type: research

Integrating machine learning and single-cell trajectories to analyze T-cell exhaustion to predict prognosis and immunotherapy in colon cancer patients
ConclusionIn this study, we systematically explored the T-cell exhaustion trajectory in COAD and developed a TES model to assess prognosis and provide guidelines for the treatment decision. This discovery gave rise to a fresh concept for novel therapeutic procedures for the clinical treatment of COAD.
Source: Frontiers in Immunology - May 3, 2023 Category: Allergy & Immunology Source Type: research

A novel prognostic related lncRNA signature associated with amino acid metabolism in glioma
ConclusionNovel amino-related lncRNAs associated with the survival of glioma patients were identified, and a lncRNA signature can predict glioma prognosis and therapy response, which possibly has vital roles in glioma. Meanwhile, it emphasized the importance of amino acid metabolism in glioma, particularly in providing deeper research at the molecular level.
Source: Frontiers in Immunology - April 11, 2023 Category: Allergy & Immunology Source Type: research

Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity
In this study, we investigated the role of CXCL1, a cytokine which increased in the serum and cochlea by 24 h following cisplatin administration. Adult male Wistar rats treated with cisplatin demonstrated significant hearing loss, assessed by auditory brainstem responses (ABRs), hair cell loss and loss of ribbon synapse. Immunohistochemical studies evaluated the levels of CXCL1 along with increased presence of CD68 and CD45-positive immune cells in cochlea. Increases in CXCL1 was time-dependent in the spiral ganglion neurons and organ of Corti and was associated with progressive increases in CD45, CD68 and IBA1-positive i...
Source: Frontiers in Immunology - March 31, 2023 Category: Allergy & Immunology Source Type: research

TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway
ConclusionMAZ silencing inhibited tumor progress of thyroid cancer cells, whereas this inhibitory effect was reversed by TBK1 overexpression.
Source: Immunity, Inflammation and Disease - March 14, 2023 Category: Allergy & Immunology Authors: Qiuli Jiang, Yingying Guan, Jingmei Zheng, Huadong Lu Tags: ORIGINAL ARTICLE Source Type: research

Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk
Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide. While HPV infection can be cleared by an adequate immune response, immunocompromised individuals can develop persistent, treatment-refractory, and progressive disease. Primary immunodeficiencies (PIDs) associated with HPV-related disease include inborn errors of GATA, EVER1/2, and CXCR4 mutations, resulting in defective cellular function. People living with secondary immunodeficiency (e.g. solid-organ transplants recipients of immunosuppression) an...
Source: Frontiers in Immunology - March 7, 2023 Category: Allergy & Immunology Source Type: research

The Long Noncoding RNA MEG3 Retains Epithelial-Mesenchymal Transition by Sponging miR-146b-5p to Regulate SLFN5 Expression in Breast Cancer Cells
J Immunol Res. 2022 Aug 18;2022:1824166. doi: 10.1155/2022/1824166. eCollection 2022.ABSTRACTMore and more studies have shown that long noncoding RNAs (lncRNAs) play essential roles in malignant tumors. The lncRNA MEG3 serves as a crucial molecule in breast cancer development, but the specific molecular mechanism needs to be further explored. We previously reported that Schlafen family member 5 (SLFN5) inhibits breast cancer malignant development by regulating epithelial-mesenchymal transition (EMT), invasion, and proliferation/apoptosis. Herein, we demonstrated that MEG3 was downregulated in pan-cancers and correlated wit...
Source: Journal of Immunology Research - August 29, 2022 Category: Allergy & Immunology Authors: Xuefeng Gu Jingyi Li Xiaojia Zuo Kaijie Chen Guoqing Wan Li-Li Deng Weiming Zhao Changlian Lu Source Type: research