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Total 168 results found since Jan 2013.
Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF‐κB/microRNA 448 circuit
ConclusionPterostilbene effectively suppresses the generation of CSCs and metastatic potential under the influence of M2 TAMs via modulating EMT associated signaling pathways, specifically NF‐κB/miR488 circuit. Thus, pterostilbene could be an ideal anti‐CSC agent in clinical settings.
Source: Nahrung / Food - March 15, 2013 Category: Nutrition Authors: Ka‐Kit Mak, Alexander T. H. Wu, Wei‐Hwa Lee, Tung‐Cheng Chang, Jeng‐Fong Chiou, Liang‐Shun Wang, Chih‐Hsiung Wu, Chi‐Ying F. Huang, Yi‐Shing Shieh, Tsu‐Yi Chao, Chi‐Tang Ho, Gow‐Chin Yen, Chi‐Tai Yeh Tags: Research Article Source Type: research
3‐Caffeoyl, 4‐dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose‐induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK‐dependent pathway
ConclusionThese results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP‐1c and FAS through LKB1/SIRT1 and AMPK activation in HepG2 cells, suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation.
Source: Nahrung / Food - January 26, 2013 Category: Nutrition Authors: Yong Pil Hwang, Hyung Gyun Kim, Jae Ho Choi, Minh Truong Do, Thu Phuong Tran, Hyo Kon Chun, Young Chul Chung, Tae Cheon Jeong, Hye Gwang Jeong Tags: Research Article Source Type: research
In vitro mechanism for downregulation of ER‐α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells
ConclusionOur data provide evidence for a mechanism by which EGCG downregulates ER‐α and explains the inhibitory action of EGCG on the proliferation of ER+ PR+ cancer cells tested. We suggest that the EGCG/PR‐B signaling should be further exploited for clinical approach.
Source: Molecular Nutrition - January 1, 2013 Category: Nutrition Authors: Francesca De Amicis, Alessandra Russo, Paola Avena, Marta Santoro, Adele Vivacqua, Daniela Bonofiglio, Loredana Mauro, Saveria Aquila, Donatella Tramontano, Suzanne AW Fuqua, Sebastiano Andò Tags: Research Article Source Type: research
