Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF‐κB/microRNA 448 circuit

ConclusionPterostilbene effectively suppresses the generation of CSCs and metastatic potential under the influence of M2 TAMs via modulating EMT associated signaling pathways, specifically NF‐κB/miR488 circuit. Thus, pterostilbene could be an ideal anti‐CSC agent in clinical settings.

Source: Nahrung / Food - March 15, 2013 Category: Nutrition Authors: Ka‐Kit Mak, Alexander T. H. Wu, Wei‐Hwa Lee, Tung‐Cheng Chang, Jeng‐Fong Chiou, Liang‐Shun Wang, Chih‐Hsiung Wu, Chi‐Ying F. Huang, Yi‐Shing Shieh, Tsu‐Yi Chao, Chi‐Tang Ho, Gow‐Chin Yen, Chi‐Tai Yeh Tags: Research Article Source Type: research