3‐Caffeoyl, 4‐dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose‐induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK‐dependent pathway

ConclusionThese results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP‐1c and FAS through LKB1/SIRT1 and AMPK activation in HepG2 cells, suggesting that CDCQ plays a potential role in the prevention of lipogenesis by AMPK activation.

Source: Nahrung / Food - January 26, 2013 Category: Nutrition Authors: Yong Pil Hwang, Hyung Gyun Kim, Jae Ho Choi, Minh Truong Do, Thu Phuong Tran, Hyo Kon Chun, Young Chul Chung, Tae Cheon Jeong, Hye Gwang Jeong Tags: Research Article Source Type: research