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NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells
ConclusionOur findings suggest that NQO1 participates in the pathology of AD by regulating the expression and alternative splicing of the genes involved in apoptosis. These results extend our understanding of NQO1 in apoptotic pathways at the posttranscriptional level in AD.
Source: Brain and Behavior - April 1, 2023 Category: Neurology Authors: Yingshi Du, Gejing Liu, Dong Chen, Jinggang Yang, Jing Wang, Yue Sun, Qian Zhang, Yongming Liu Tags: ORIGINAL ARTICLE Source Type: research

GNB2 is a mediator of lidocaine-induced apoptosis in rat pheochromocytoma PC12 cells.
Abstract Lidocaine has been recognized to induce neurotoxicity. However, the molecular mechanism underlying this effect, especially the critical molecules in cells that mediated the lidocaine-induced apoptosis were unclear. In the present study, PC12 cells were administrated with lidocaine for 48h. Using MTT assay and flow cytometry, we found lidocaine significantly decreased the cell proliferation and S phases in PC12 cells with treatment concentrations, and significantly enhanced cell apoptosis with treatment concentrations. Two-dimensional gel electrophoresis (2-DE) analysis and LC-MS/MS were used to identifica...
Source: Neurotoxicology - March 22, 2016 Category: Neurology Authors: Tan Y, Wang Q, Zhao B, She Y, Bi X Tags: Neurotoxicology Source Type: research

Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91phox.
Abstract Both of gp91(phox) (an isoform of nicotinamide adenine dinucleotide phosphate reduced oxidases) and Src (a non-receptor protein tyrosine kinase) are abundantly expressed in the brain and play a prominent role in mediating ischemic alteration in neurons. The inhibitory strategy of them is believed to be the promising treatment of stroke. The present study was designed to investigate the effect of equol (0.625-2.5 mg•kg(-1), i.g. for 3 days), a predominant active metabolite of daidzein, on neuroprotection against cerebral ischemia/reperfusion injury in rats and the underlying mechanisms. We found that equ...
Source: Current Neurovascular Research - September 7, 2014 Category: Neurology Authors: Wei YU, Wang Y, Zhou DX, Zhao LM, Li GR, Deng XL Tags: Curr Neurovasc Res Source Type: research