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Specialty: General Medicine

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Total 380 results found since Jan 2013.

FABP4 alleviates endoplasmic reticulum stress-mediated ischemia-reperfusion injury in PC12 cells via regulation of PPAR γ.
FABP4 alleviates endoplasmic reticulum stress-mediated ischemia-reperfusion injury in PC12 cells via regulation of PPARγ. Exp Ther Med. 2021 Mar;21(3):181 Authors: Yang XL, Mi JH, Dong Q Abstract Ischemic stroke is a life-threatening complication with a high rate of morbidity. Circulating fatty acid binding protein 4 (FABP4) has been reported to be associated with the outcome of acute ischemic stroke. The present study aimed to illustrate the function of FABP4 in ischemic stroke. PC12 cells exposed to oxygen glucose deprivation/reoxygenation (OGD/R) were used to mimic ischemia-reperfusion (I/R) injury...
Source: Experimental and Therapeutic Medicine - January 27, 2021 Category: General Medicine Tags: Exp Ther Med Source Type: research

Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway.
Authors: Zhao B, Li GP, Peng JJ, Ren LH, Lei LC, Ye HM, Wang ZY, Zhao S Abstract Schizandrin B exhibits prominent antioxidant and anti-inflammatory effects, and plays an important role in ameliorating myocardial ischemia/reperfusion injury. However, the underlying protective mechanisms remain to be elucidated. The aim of the present study was to explore the cardioprotective effects of schizandrin B against hypoxia/reoxygenation (H/R)-induced H9c2 cell injury, focusing on the role of the adenosine monophosphate-activated protein kinase (AMPK)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in this process...
Source: Experimental and Therapeutic Medicine - February 20, 2021 Category: General Medicine Tags: Exp Ther Med Source Type: research

Integrin α7 knockdown suppresses cell proliferation, migration, invasion and EMT in hepatocellular carcinoma
In conclusion, ITGA7 knockdown suppressed HCC progression and inhibited EMT in HCC in vitro, implying that ITGA7 might be a novel treatment target for HCC.PMID:33717252 | PMC:PMC7885058 | DOI:10.3892/etm.2021.9740
Source: Experimental and Therapeutic Medicine - March 15, 2021 Category: General Medicine Authors: Zhiyong Wu Xiaoyu Kong Zhihui Wang Source Type: research

Inhibitory effect of miR-140-5p on doxorubicin resistance of hepatocellular carcinoma
Exp Ther Med. 2021 May;21(5):507. doi: 10.3892/etm.2021.9938. Epub 2021 Mar 18.ABSTRACTTo investigate the role of microRNA (miR)-140-5p in doxorubicin (DOX) sensitivity in hepatocellular carcinoma, miR-140-5p and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) expression was first evaluated in hepatocellular carcinoma tissues using starBase. Next, in vitro experiments were performed. Cell line expression of miR-140-5p and PIN1 expression was detected by reverse transcription polymerase chain reaction. Cell viability and proliferation were determined by the Cell Counting Kit-8 and EdU assays. The relationship ...
Source: Experimental and Therapeutic Medicine - April 1, 2021 Category: General Medicine Authors: Xiaojie Gao Yan Jiang Yingying Li Source Type: research

Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis
CONCLUSION: These findings suggest that the increased expression of S100B and RAGE and the interaction between S100B and RAGE may play an important role in ductular reaction and liver fibrosis induced by BDL.PMID:33847081 | DOI:10.3346/jkms.2021.36.e90
Source: J Korean Med Sci - April 13, 2021 Category: General Medicine Authors: Ji Won Park Mo Jong Kim Sung Eun Kim Hee Jun Kim Yong Chul Jeon Hae Young Shin Se Jin Park Myoung Kuk Jang Dong Joon Kim Choong Kee Park Eun Kyoung Choi Source Type: research

Effect of the ACY-1 gene on HER2 and TRAIL expression in rectal carcinoma
Exp Ther Med. 2021 Aug;22(2):817. doi: 10.3892/etm.2021.10249. Epub 2021 Jun 2.ABSTRACTThe incidence of rectal carcinoma (RC) is increasing and the age at onset of the disease is reducing. Therefore, elucidating the pathogenesis of RC is beneficial for early diagnosis and improving the prognosis. Aminoacylase-1 (ACY-1) is abnormally expressed in various malignant tumor tissues. Furthermore, the human epidermal growth factor receptor-2 (HER2) gene is involved in tumor metastasis and invasion, while tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumor cell apoptosis. The aim of the present study was ...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Zizhong Xu Yating Hu Zhaohui Yu Source Type: research