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Specialty: General Medicine

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Total 380 results found since Jan 2013.

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research

The X box binding protein 1/C/EBP homologous protein pathway induces apoptosis of endothelial cells under hyperglycemia
Exp Ther Med. 2022 May 18;24(1):454. doi: 10.3892/etm.2022.11381. eCollection 2022 Jul.ABSTRACTVenous endothelial cell apoptosis can be induced by endoplasmic reticulum (ER) stress, thus serving an important role in the formation of deep venous thrombosis. X-box binding protein 1 (XBP1) is a protein associated with ER. The present study aimed to explore the function of XBP1/C/EBP homologous protein (CHOP) pathway in the process of endothelial cell apoptosis under hyperglycemia. Small interfering (si)RNAs targeting XBP1 and CHOP were designed to downregulate the expression of XBP1 and CHOP in human umbilical vein endothelia...
Source: Experimental and Therapeutic Medicine - June 20, 2022 Category: General Medicine Authors: Maoshun Tang Yi Zheng Jianping Li Yuanlang Hu Source Type: research

GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway
In conclusion, GRWD1 knockdown could suppress the proliferation, invasion and migration and promoted apoptosis of TNBC cells through inhibiting the Notch signaling pathway.PMID:35761807 | PMC:PMC9214606 | DOI:10.3892/etm.2022.11400
Source: Experimental and Therapeutic Medicine - June 28, 2022 Category: General Medicine Authors: Liang Yao Fuguo Tian Source Type: research