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CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
ConclusionCCT6A facilitates ESCC malignant activities by activating the TGF- β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.
Source: Irish Journal of Medical Science - April 5, 2023 Category: General Medicine Source Type: research

GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway
In conclusion, GRWD1 knockdown could suppress the proliferation, invasion and migration and promoted apoptosis of TNBC cells through inhibiting the Notch signaling pathway.PMID:35761807 | PMC:PMC9214606 | DOI:10.3892/etm.2022.11400
Source: Experimental and Therapeutic Medicine - June 28, 2022 Category: General Medicine Authors: Liang Yao Fuguo Tian Source Type: research

ChaC glutathione specific γ-glutamylcyclotransferase 1 inhibits cell viability and increases the sensitivity of prostate cancer cells to docetaxel by inducing endoplasmic reticulum stress and ferroptosis
Exp Ther Med. 2021 Sep;22(3):997. doi: 10.3892/etm.2021.10429. Epub 2021 Jul 15.ABSTRACTThe present study aimed to determine the effects and mechanism of ChaC glutathione specific γ-glutamylcyclotransferase 1 (CHAC1) on cell viability and the sensitivity of prostate cancer cells to docetaxel. Compared with non-tumor human prostate epithelial RWPE-1 cells, the mRNA and protein levels of CHAC1 significantly decreased in two prostate cancer cell lines, DU145 and 22RV1, as measured by quantitative polymerase chain reaction and western blot analysis (P<0.05). The cell viability and glutathione (GSH) levels were significantl...
Source: Experimental and Therapeutic Medicine - August 4, 2021 Category: General Medicine Authors: Saifei He Miao Zhang Ying Ye Juhua Zhuang Xing Ma Yanan Song Wei Xia Source Type: research

Effect of the ACY-1 gene on HER2 and TRAIL expression in rectal carcinoma
Exp Ther Med. 2021 Aug;22(2):817. doi: 10.3892/etm.2021.10249. Epub 2021 Jun 2.ABSTRACTThe incidence of rectal carcinoma (RC) is increasing and the age at onset of the disease is reducing. Therefore, elucidating the pathogenesis of RC is beneficial for early diagnosis and improving the prognosis. Aminoacylase-1 (ACY-1) is abnormally expressed in various malignant tumor tissues. Furthermore, the human epidermal growth factor receptor-2 (HER2) gene is involved in tumor metastasis and invasion, while tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces tumor cell apoptosis. The aim of the present study was ...
Source: Experimental and Therapeutic Medicine - June 16, 2021 Category: General Medicine Authors: Zizhong Xu Yating Hu Zhaohui Yu Source Type: research

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