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Sinomenine increases adenosine A < sub > 2A < /sub > receptor and inhibits NF- κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR
J Leukoc Biol. 2021 Aug 23. doi: 10.1002/JLB.3MA0121-024RRRR. Online ahead of print.ABSTRACTSinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti-inflammatory and immunosuppressive function. However, the mechanisms of SIN acting on α7nAChR and the effect on adenosine A2A receptor (A2A R) in RA are not clear. In the present study, the effects of SIN on adjuvant-induced-arthritis (AIA) rats in vivo and on fibroblast-like synoviocyte...
Source: Journal of Leukocyte Biology - August 23, 2021 Category: Hematology Authors: Lang Yi Junyu Ke Jiayan Liu Huili Lai Yanjun Lv Chong Peng Yingkun Zhi Qun Du Liang Liu Peixun Wang Hua Zhou Yan Dong Source Type: research

Silencing Long Non-Coding RNA ST3GAL6-AS1 Inhibits Adhesion and Migration of Myeloma Cells in Vitro
Conclusions: Knockdown of ST3GAL6-AS1 in MM cells significantly inhibits adhesion, migration and invasion in vitro, indicating that ST3GAL6-AS1 may play an important role in the malignant behavior of MM cells. The co-expression between ST3GAL6-AS1 and gene ST3GAL6 has been demonstrated in our previous study, which was further confirmed in present study. Researches are ongoing to address the potential mechanism among them in MM.Figure 1.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Shen, Y., Feng, Y., Chen, H., Jia, Y., Peng, Y., Zhang, R., Yang, Y., Wang, J.-L., Bai, J., Wang, F.-X., Xu, Y., Hu, J., He, A. Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster III Source Type: research

FOXM1 and the NPM-ALK/STAT3 Axis Form a Novel Positive Feedback Loop in Promoting the Oncogenesis of ALK-Positive Anaplastic Large Cell Lymphoma
Conclusions:In conclusion, we have identified a novel oncogenic feedback loop involving FOXM1 and the NPM-ALK/STAT3 axis in ALK+ALCL. This study has revealed the first clear example in which NPM-ALK exerts important oncogenic functions in the nuclei of ALK+ALCL cells, by means of its binding to an oncogenic transcription factor so as to promote its DNA binding and transcription activity.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Wang, P., Haque, M., Li, J., Huang, Y.-H., Almowaled, M., Bargar, C., Karpf, A., Chen, W., Turner, S., Lai, R. Tags: 603. Oncogenes and Tumor Suppressors: Poster III Source Type: research