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ASAP Iron Oxide Nanoparticles Decorated with Functional Peptides for a Targeted siRNA Delivery to Glioma Cells
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c17802
Source: ACS Applied Materials and Interfaces - November 28, 2022 Category: Materials Science Authors: Seokhwan Chung, Yutaro Sugimoto, Jianxi Huang, and Miqin Zhang Source Type: research

Targeted transport of nanocarriers into brain for theranosis with rabies virus glycoprotein-derived peptide
Publication date: 1 June 2018 Source:Materials Science and Engineering: C, Volume 87 Author(s): Chen Fu, Yonggang Xiang, Xiaorong Li, Ailing Fu For successful theranosis of brain diseases, limited access of therapeutic molecules across blood-brain barrier (BBB) needs be overcome in brain delivery. Currently, peptide derivatives of rabies virus glycoprotein (RVG) have been exploited as delivery ligands to transport nanocarriers across BBB and specifically into the brain. The targeting peptides usually conjugate to the nanocarrier surface, and the cargoes, including siRNA, miRNA, DNA, proteins and small molecular chemicals,...
Source: Materials Science and Engineering: C - March 17, 2018 Category: Materials Science Source Type: research

Single-component self-assembled RNAi nanoparticles functionalized with tumor-targeting iNGR delivering abundant siRNA for efficient glioma therapy.
In this study, a novel glioma-targeting RNAi system was developed. Single-component RNAi nanospheres were tactfully self-assembled in vitro, combining the carrier and cargo as a whole. An artificially synthesized polycation (pOEI) with redox-sensitive disulfides in structure condensed the RNAi nanospheres into more compacted nanoparticles. Then a novelly designed tumor-homing and penetrating cyclopeptide iNGR was further modified on the surface. iNGR modified RNAi nanoparticles demonstrated significantly enhanced accumulation in glioma site, remaining stable in circulation until the release of naked RNAi nanospheres were ...
Source: Biomaterials - April 24, 2015 Category: Materials Science Authors: An S, Jiang X, Shi J, He X, Li J, Guo Y, Zhang Y, Ma H, Lu Y, Jiang C Tags: Biomaterials Source Type: research

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.
In this study, we report an effective strategy for cancer therapy through targeting glucose transporter 3 (GLUT3) with siRNA-based nanomedicine to simultaneously inhibit the self-renewal of glioma stem cells and bulk glioma cells in a glucose restricted tumor micro-environment. We have demonstrated that cationic lipid-assisted poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PLA) nanoparticles can efficiently deliver siRNA into U87MG and U251 glioma stem cells and bulk glioma cells. Nanoparticles carrying specific siRNA targeting GLUT3 (NPsiGLUT3) were able to significantly reduce the expression of GLUT3 in glioma stem cells...
Source: Biomaterials - March 20, 2015 Category: Materials Science Authors: Xu CF, Liu Y, Shen S, Zhu YH, Wang J Tags: Biomaterials Source Type: research