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Precision medicine-guided co-delivery of ASPN siRNA and oxaliplatin by nanoparticles to overcome chemoresistance of colorectal cancer
This study uncovered the critical role of ASPN in causing OXA resistance in CRC patients and suggests a promising nanoformulation that may be more effective than current standard-of-care medications.PMID:36228517 | DOI:10.1016/j.biomaterials.2022.121827
Source: Biomaterials - October 13, 2022 Category: Materials Science Authors: Cheng-Zhi Huang Yue Zhou Qi-Song Tong Qi-Jia Duan Qing Zhang Jin-Zhi Du Xue-Qing Yao Source Type: research

ASAP Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and < italic toggle="yes" > Pcsk9 < /italic > siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c06001
Source: ACS Applied Materials and Interfaces - July 11, 2022 Category: Materials Science Authors: Wenjing Guo, Huabin Gao, Hui Li, Songhan Ge, Fenfen Zhang, Liyuan Wang, Huijuan Shi, and Anjia Han Source Type: research

ASAP Nanodrugs Incorporating LDHA siRNA Inhibit M2-like Polarization of TAMs and Amplify Autophagy to Assist Oxaliplatin Chemotherapy against Colorectal Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c05841
Source: ACS Applied Materials and Interfaces - July 7, 2022 Category: Materials Science Authors: Lijun Hu, Sicong Huang, Gengjia Chen, Bo Li, Tan Li, Minzhao Lin, Yongquan Huang, Zecong Xiao, Xintao Shuai, and Zhongzhen Su Source Type: research

ASAP Functionalized LbL Film for Localized Delivery of STAT3 siRNA and Oxaliplatin Combination to Treat Colon Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c22166
Source: ACS Applied Materials and Interfaces - February 16, 2022 Category: Materials Science Authors: Leela Sai Lokesh Janardhanam, Sony Priyanka Bandi, and Venkata Vamsi Krishna Venuganti Source Type: research

Silencing KLK12 expression via RGDfC-decorated selenium nanoparticles for the treatment of colorectal cancer in vitro and in vivo
Publication date: May 2020Source: Materials Science and Engineering: C, Volume 110Author(s): Yu Xia, Guoyi Tang, Min Guo, Tiantian Xu, Haiyang Chen, Zhengfang Lin, Yinghua Li, Yi Chen, Bing Zhu, Hongsheng Liu, Jie CaoAbstractShort interfering RNA (siRNA) has been investigated as a promising modality of cancer treatment due to its capability to target specific target genes for downregulation. However, the successful application of this strategy depends on producing a safe and effective carrier system for delivering siRNA to the tumor. Thus, investigation of siRNA delivery carriers is a fundamental step in the field of siRNA...
Source: Materials Science and Engineering: C - February 16, 2020 Category: Materials Science Source Type: research