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Specialty: Cytology
Condition: Liver Disease
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Total 34 results found since Jan 2013.
Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation
In conclusion, our findings uncovered that I3A increased hepatic PGC1a expression, contributing to mitochondrial respiration improvement in NAFLD.PMID:35988807 | DOI:10.1016/j.cellsig.2022.110442
Source: Cellular Signalling - August 21, 2022 Category: Cytology Authors: Chen Zhang Qingsong Fu Kai Shao Limin Liu Xiaotian Ma Fengyi Zhang Xiaodong Zhang Liying Meng ChuanZhu Yan Xiaoyun Zhao Source Type: research
Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway
In this study, we attempted to investigate a novel mechanism by which WG mitigates liver fibrosis by inducing ferroptosis in hepatic stellate cells (HSCs). A CCl4 -induced mouse liver fibrosis model and a rat HSC line were employed for in vivo and in vitro experiments, both treated with WG. Firstly, the levels of the fibrotic markers α-smooth muscle actin (α-SMA) and α1(I)collagen (COL1α1) were effectively decreased by WG in CCl4 -induced mice and HSC-T6 cells. Additionally, mitochondrial condensation and mitochondrial ridge breakage were observed in WG-treated HSC-T6 cells. Furthermore, ferroptotic events including de...
Source: Cell Research - July 11, 2022 Category: Cytology Authors: Guofang Liu Can Wei Siyu Yuan Zhe Zhang Jiahao Li Lijun Zhang Guokai Wang Ling Fang Source Type: research
Abietic acid alleviates endoplasmic reticulum stress and lipid accumulation in human primary hepatocytes through the AMPK/ORP150 signaling
This study investigated the impacts of AA on ER stress and steatosis in in vitro obesity models. We found that Treatment with AA reduced lipid deposition and lipogenesis-related proteins expression in human primary hepatocytes. Augmented expression of ER stress markers (phospho-eukaryotic initiation factor-2α (eIF2α) and C/EBP homologous protein (CHOP)) in palmitate-treated hepatocytes were reversed by AA treatment. Further, AA treatment increased the expression of phospho-AMPK and oxygen-regulated protein 150 (ORP150) in hepatocytes. siRNA-associated knockdown of AMPK or ORP150 expression reduced the effects of AA on no...
Source: Cell Research - April 10, 2022 Category: Cytology Authors: Tae Woo Jung Ju-Cheol Jeong Seung Yeon Park Wonjun Cho Heeseung Oh Hyun Jung Lee Ahmet Hacimuftuoglu A M Abd El-Aty Joon Seok Bang Ji Hoon Jeong Source Type: research
Harmine suppresses collagen production in hepatic stellate cells by inhibiting DYRK1B
Biochem Biophys Res Commun. 2022 Feb 16;600:136-141. doi: 10.1016/j.bbrc.2022.02.054. Online ahead of print.ABSTRACTLiver fibrosis is a major consequence of chronic liver disease, where excess extracellular matrix is deposited, due caused by the activation of hepatic stellate cells (HSCs). The suppression of collagen production in HSCs is therefore regarded as a therapeutic target of liver fibrosis. The present study investigated effects of harmine, which is a β-carboline alkaloid and known as an inhibitor of dual-specificity tyrosine-regulated kinases (DYRKs), on the production of collagen in HSCs. LX-2 cells, a human HS...
Source: Cell Research - February 26, 2022 Category: Cytology Authors: Momoka Yamaguchi Saya Ohbayashi Akira Ooka Hinako Yamashita Nanami Motohashi Yukiko K Kaneko Toshihide Kimura Shin-Ya Saito Tomohisa Ishikawa Source Type: research
Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine
Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. When FMO1 is silenced, the effects of high fat and TMA on TMAO are blocked. And the role of TMAO in NAFLD may be through the activation of UPR.PMID:35065293 | DOI:10.1016/j.bbrc.2022.01.060
Source: Cell Research - January 22, 2022 Category: Cytology Authors: Chunxia Shi Maohua Pei Yao Wang Qian Chen Pan Cao Luyi Zhang Jin Guo Wei Deng Luwen Wang Xun Li Zuojiong Gong Source Type: research
Nicotinamide N-methyltransferase (NNMT) upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes
In this study, using AML12 cells, a non-transformed murine hepatocyte cell line, exposed to palmitate (a 16-C saturated fatty acid) as an experimental model, we investigated the role and mechanisms of nicotinamide N-methyltransferase (NNMT), a methyltransferase catalyzing nicotinamide methylation and degradation, in hepatic lipotoxicity. We initially identified activating transcription factor 4 (ATF4) as a major transcription factor for hepatic NNMT expression. Here, we demonstrated that palmitate upregulates NNMT expression via activating ATF4 in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent mechanism in ...
Source: American Journal of Physiology. Cell Physiology - August 11, 2021 Category: Cytology Authors: Alexandra Griffiths Jun Wang Qing Song Iredia D Iyamu Lifeng Liu Jooman Park Yuwei Jiang Rong Huang Zhenyuan Song Source Type: research
