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Specialty: Cytology
Condition: Asthma
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Total 32 results found since Jan 2013.
IRAK-M has effects in regulation of lung epithelial inflammation
CONCLUSION: Our findings suggested that IRAK-M has effect on lung epithelial inflammation with an influence on epithelial secretion of CXCL10 partly mediated through JNK and p38 MAPK pathways. IRAK-M modulation might indicate a new insight into asthma pathogenesis from disease origin.PMID:37029363 | DOI:10.1186/s12931-023-02406-5
Source: Cell Research - April 7, 2023 Category: Cytology Authors: Jia Li Zhoude Zheng Yi Liu Hongbing Zhang Youming Zhang Jinming Gao Source Type: research
Amphiregulin induces CCN2 and fibronectin expression by TGF- β through EGFR-dependent pathway in lung epithelial cells
CONCLUSION: These results suggested that AREG mediates the TGF-β-induced EMT in human lung epithelial cells through EGFR/JNK/AP-1 activation. Understanding the role of AREG in the EMT could foster the development of therapeutic strategies for airway remodeling in severe asthma.PMID:36578010 | DOI:10.1186/s12931-022-02285-2
Source: Cell Research - December 28, 2022 Category: Cytology Authors: Wun-Hao Cheng Shih-Ya Kao Chia-Ling Chen Fara Silvia Yuliani Lee-Yuan Lin Chien-Huang Lin Bing-Chang Chen Source Type: research
IL-24 Contributes to Neutrophilic Asthma in an IL-17A-Dependent Manner and Is Suppressed by IL-37
CONCLUSIONS: IL-24 aggravated neutrophilic airway inflammation by increasing epithelium-derived IL-17A production, which could be suppressed by IL-37. Targeting the IL-24/IL-17A signaling axis is a potential strategy, and IL-37 is a potential candidate agent for alleviating neutrophilic airway inflammation in asthma.PMID:36174993 | DOI:10.4168/aair.2022.14.5.505
Source: Cell Research - September 29, 2022 Category: Cytology Authors: Kang-Ni Feng Ping Meng Min Zhang Xiao-Ling Zou Shuang Li Chu-Qin Huang Ke-Fang Lai Hong-Tao Li Tian-Tuo Zhang Source Type: research
Melatonin MT < sub > 2 < /sub > receptor is expressed and potentiates contraction in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 6. doi: 10.1152/ajplung.00273.2021. Online ahead of print.ABSTRACTNocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracellular cyclic AMP (c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - October 6, 2021 Category: Cytology Authors: Haruka Sasaki Yi Zhang Charles W Emala Kentaro Mizuta Source Type: research
Store-operated Calcium Entry-associated Regulatory Factor Regulates Airway Inflammation and Airway Remodeling in Asthma Mice Models
CONCLUSIONS: SARAF plays a protective role against airway inflammation and remodeling in asthma mice models by blunting SOCE; SARAF may also be a functional regulating factor of hASMCs.PMID:34231388 | DOI:10.1152/ajplung.00079.2020
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - July 7, 2021 Category: Cytology Authors: Yi-Min Wang Wen-Juan Xu Lin-Li Xiang Mei Ding Jin-Jin Zhang Jing-Ya Lu Bao-Juan Xie Ya-Dong Gao Source Type: research
